2-[(2R)-1-methylpyrrolidin-2-yl]acetaldehyde | 1039074-75-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-[(2R)-1-methylpyrrolidin-2-yl]acetaldehyde
• CAS: 1039074-75-3
• 化学式: C₇H₁₃NO
• 分子量: 127.186
• InChiKey: PPNSGZWFXWAMND-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-[(2R)-1-methylpyrrolidin-2-yl]acetaldehyde 、 甲基溴化镁 以 四氢呋喃 为溶剂， 生成 1-((R)-1-Methylpyrrolidin-2-yl)propan-2-ol
  参考文献：
  名称：

  A short synthesis of (+)-hygrine

  摘要：

  The synthesis of the alkaloid hygrine in a series of six steps starting from readily available proline N-methyl derivative (5) is described. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.04.098
• 作为产物：
  描述：

  (甲氧基甲基)三苯基溴化膦 、 (R)-1-甲基吡咯烷-2-甲醛 在 potassium tert-butylate 、 盐酸 作用下， 以 四氢呋喃 为溶剂， 生成 2-[(2R)-1-methylpyrrolidin-2-yl]acetaldehyde
  参考文献：
  名称：

  A short synthesis of (+)-hygrine

  摘要：

  The synthesis of the alkaloid hygrine in a series of six steps starting from readily available proline N-methyl derivative (5) is described. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.04.098

文献信息

• Fumagillol heterocyclic compounds and methods of making and using same
  申请人：Zafgen, Inc.

  公开号：US10023561B2

  公开（公告）日：2018-07-17

  Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.

  本文部分公开了烟曲霉素化合物和用于治疗肥胖等疾病的方法。提供了药物组合物和制造烟嘧酚化合物的方法。这些化合物对蛋氨酰氨基肽酶 2 具有活性。
• FUMAGILLOL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
  申请人：Zafgen, Inc.

  公开号：US20170066749A1

  公开（公告）日：2017-03-09

  Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
• US9682965B2
  申请人：——

  公开号：US9682965B2

  公开（公告）日：2017-06-20
• A short synthesis of (+)-hygrine
  作者：Enzo B. Arévalo-García、Juan Carlos Q. Colmenares

  DOI：10.1016/j.tetlet.2008.04.098

  日期：2008.6

  The synthesis of the alkaloid hygrine in a series of six steps starting from readily available proline N-methyl derivative (5) is described. (C) 2008 Elsevier Ltd. All rights reserved.