N-Dimethylaminosulfonyl-morpholin | 5433-57-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-Dimethylaminosulfonyl-morpholin
• 英文别名: morpholine-4-sulfonic acid dimethylamide；Morpholin-4-sulfonsaeure-dimethylamid；n,n-Dimethylmorpholine-4-sulfonamide
• CAS: 5433-57-8
• 化学式: C₆H₁₄N₂O₃S
• mdl: MFCD01055935
• 分子量: 194.255
• InChiKey: OPFOHHASSCNHHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  吗啉 、 二甲胺基磺酰氯 生成 N-Dimethylaminosulfonyl-morpholin
  参考文献：
  名称：

  Heterocyclic Derivatives of Sulfamide¹

  摘要：

  DOI：

  10.1021/ja01224a005

文献信息

• Alkylacetylene substituted Acyltryptophanols
  申请人：Bayer Schering Pharma AG

  公开号：EP2019102A1

  公开（公告）日：2009-01-28

  The present invention relates to acyltryptophanols of the general formula I, in which R1, R2, R3, Q and X have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.

  本发明涉及一般式I的酰基色氨酸醇，其中R1、R2、R3、Q和X的含义如描述中所定义。本发明中的化合物是有效的FSH拮抗剂，例如可用于男性或女性的生育控制，或用于骨质疏松症的预防和/或治疗。
• SULFONYLTRYPTOPHANOLS
  申请人：WORTMANN Lars

  公开号：US20080255117A1

  公开（公告）日：2008-10-16

  The present invention relates to sulfonyltryptophanols of the general formula I, in which Q, X, W, R1, R2, R3, R4, R5, R6, R7 and R8 have the meaning as defined in the description. The compounds according to the invention are effective FSH receptor antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.

  本发明涉及通式I的磺酰基色氨酸醇化合物，其中Q，X，W，R1，R2，R3，R4，R5，R6，R7和R8的含义如描述中所定义。本发明的化合物是有效的FSH受体拮抗剂，例如可以用于男性或女性的生育控制，或用于骨质疏松症的预防和/或治疗。
• 1,2-DIARYLACETYLENE DERIVATIVES OF ACYLTRYPTOPHANOLS
  申请人：Wortmann Lars

  公开号：US20080221195A1

  公开（公告）日：2008-09-11

  The present invention relates to acyltryptophanols of the general formula I, in which Q, W, R1, R2, R3, R4, R5, R6, R7 and R8 have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.

  本发明涉及一般式I的酰基色氨酸醇，其中Q，W，R1，R2，R3，R4，R5，R6，R7和R8的含义如描述中所定义。本发明的化合物是有效的FSH拮抗剂，例如可用于男性或女性的生育控制，或用于骨质疏松症的预防和/或治疗。
• BICYCLIC ACYLTRYPTOPHANOLS
  申请人：Wortmann Lars

  公开号：US20080207728A1

  公开（公告）日：2008-08-28

  The present invention relates to acyltryptophanols of the general formula I, in which Q, V, X, W, R1, R2, R3, R4, R5, R6, R7 and R8 have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.

  本发明涉及一般式I的酰基色氨酸醇，其中Q、V、X、W、R1、R2、R3、R4、R5、R6、R7和R8的含义如描述中所定义。本发明的化合物是有效的FSH拮抗剂，例如可用于男性或女性的生育控制，或用于骨质疏松的预防和/或治疗。
• Arylmethylene Substituted N-Acyl-Beta-Amino Alcohols
  申请人：WORTMANN Lars

  公开号：US20090082372A1

  公开（公告）日：2009-03-26

  The present invention relates to arylmethylene substituted N-Acyl-β-amino alcohols of the formula I in which Y is selected from the aryl or heteroaryl groups: and R1, R2, R3, R4, R5, Q, X and W have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.

  本发明涉及公式I的芳基亚甲基取代的N-酰基-β-氨基醇化合物，其中Y选自芳基或杂芳基基团：R1，R2，R3，R4，R5，Q，X和W的含义如描述中所定义。本发明的化合物是有效的FSH拮抗剂，例如可用于男性或女性的生育控制，或用于骨质疏松症的预防和/或治疗。