N-[(六氢-1H-氮杂卓-1-基)羰基]-L-亮氨酰-1-甲酰基-D-色氨酰-D-色氨酸 | 141595-53-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-[(六氢-1H-氮杂卓-1-基)羰基]-L-亮氨酰-1-甲酰基-D-色氨酰-D-色氨酸
• 中文别名: 中文名称暂缺
• 英文名称: (N,N-hexamethylene)carbamoyl-Leu-D-Trp(CHO)-D-Trp-OH
• 英文别名: BQ 610；BQ-610；BQ610；D-tryptophan; N-(1-formyl-N-(N-8hexahydro-1H-azepin-1-yl)carbonyl)-L-leucyl)-D-tryptophyl；N-[1-formyl-N-[N-[(hexahydro-1H-azepin-1-yl)carbonyl]-L-leucyl]-D-tryptophyl]-D-tryptophan；(2R)-2-[[(2R)-2-[[(2S)-2-(azepane-1-carbonylamino)-4-methylpentanoyl]amino]-3-(1-formylindol-3-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoic acid
• CAS: 141595-53-1
• 化学式: C₃₆H₄₄N₆O₆
• 分子量: 656.782
• InChiKey: QHSRPPJQBFQWSC-OJDZSJEKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  48
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  166
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• Irrigation solution and method for inhibition of pain and inflammation
  申请人：Omeros Corporation

  公开号：EP1563838A2

  公开（公告）日：2005-08-17

  A method and solution for perioperatively inhibiting a variety of pain and inflammation, processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes at least one α2- receptor agonist and, optionally, additional multiple pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation, includes an α2- receptor agonist, a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin1 antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin1 antagonist, a bradykinin2 antagonist and a µ-opioid agonist.

  一种围手术期抑制包括口腔/牙科手术在内的一般外科手术伤口处各种疼痛和炎症过程的方法和溶液。该溶液最好包括至少一种α2-受体激动剂，另外还包括在生理载体（如生理盐水或乳酸林格氏液）中稀释浓度的多种疼痛和炎症抑制剂。该溶液可在手术过程中通过持续冲洗伤口来预先抑制疼痛，同时避免口服、肌肉注射、皮下注射或静脉注射大剂量药物所带来的不良副作用。一种优选的抑制疼痛和炎症的方案包括α2 受体激动剂、5-羟色胺2 拮抗剂、5-羟色胺3 拮抗剂、组胺拮抗剂、5-羟色胺激动剂、环氧化酶抑制剂、神经激肽1 拮抗剂、组胺拮抗剂、5-羟色胺激动剂、环氧化酶抑制剂、神经激肽 1 拮抗剂、神经激肽 2 拮抗剂、嘌呤受体拮抗剂、ATP 敏感性钾通道开放剂、钙通道拮抗剂、缓激肽 1 拮抗剂、缓激肽 2 拮抗剂和 µ 阿片类激动剂。
• Methods and compositions for emergency contraception using endothelin receptor antagonists
  申请人：THE POPULATION COUNCIL, INC.

  公开号：EP2246062A1

  公开（公告）日：2010-11-03

  Disclosed are methods and compositions containing endothelin receptor antagonists for emergency contraception.

  所公开的是含有内皮素受体拮抗剂的用于紧急避孕的方法和组合物。
• Surgical irrigation solution and method for inhibition of pain and inflammation
  申请人：Omeros Medical Systems, Inc.

  公开号：US20010044616A1

  公开（公告）日：2001-11-22

  A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a serotonin 2 antagonist, a serotonin 3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin 1 antagonist, a neurokinin 2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin 1 antagonist, a bradykinin 2 antagonist and a &mgr;-opioid agonist.

  一种围手术期抑制一般外科手术（包括口腔/牙科手术）伤口处各种疼痛和炎症过程的方法和溶液。该溶液优选在生理载体（如生理盐水或乳酸林格氏液）中加入多种稀释浓度的疼痛和炎症抑制剂。该溶液可在手术过程中通过持续冲洗伤口来预先抑制疼痛，同时避免口服、肌肉注射、皮下注射或静脉注射大剂量制剂所带来的不良副作用。抑制疼痛和炎症的一种首选方案包括血清素 2 拮抗剂、血清素 3 拮抗剂、组胺拮抗剂、血清素激动剂、环氧化酶抑制剂、神经激肽 1 拮抗剂、神经激肽 2 拮抗剂、嘌呤受体拮抗剂、ATP 敏感性钾通道开放剂、钙通道拮抗剂、缓激肽 1 拮抗剂、缓激肽 2 拮抗剂和阿片激动剂。
• Irrigation solution and method for inhibition of pain, inflammation, spasm and restenosis
  申请人：Omeros Medical Systems, Inc.

  公开号：US20030105126A1

  公开（公告）日：2003-06-05

  A method and solution for perioperatively inhibiting a variety of pain, inflammation, spasm and restenosis processes resulting from cardiovascular or general surgical, therapeutic and diagnostic procedures. The solution preferably includes multiple pain and inflammation inhibitory agents, including at least one local anesthetic agent, and spasm inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. Specific preferred embodiments of the solution of the present invention for use in cardiovascular and general vascular procedures also include anti-restenosis agents.

  一种围手术期抑制心血管或一般外科手术、治疗和诊断过程中产生的各种疼痛、炎症、痉挛和再狭窄过程的方法和溶液。该溶液最好包含多种疼痛和炎症抑制剂，包括至少一种局部麻醉剂，以及稀释浓度的痉挛抑制剂，以生理载体（如生理盐水或乳酸林格氏液）为载体。用于心血管和一般血管手术的本发明溶液的具体优选实施方案还包括抗血管狭窄剂。
• Arthroscopic irrigation solution and method for inhibition of pain and inflammation
  申请人：Omeros Medical Systems, Inc.

  公开号：US20030114355A1

  公开（公告）日：2003-06-19

  A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a serotonin 2 antagonist, a serotonin 3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin 1 antagonist, a neurokinin 2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin 1 antagonist, a bradykinin 2 antagonist and a &mgr;-opioid agonist.

  一种围手术期抑制一般外科手术（包括口腔/牙科手术）伤口处各种疼痛和炎症过程的方法和溶液。该溶液优选在生理载体（如生理盐水或乳酸林格氏液）中加入多种稀释浓度的疼痛和炎症抑制剂。该溶液可在手术过程中通过持续冲洗伤口来预先抑制疼痛，同时避免口服、肌肉注射、皮下注射或静脉注射大剂量制剂所带来的不良副作用。抑制疼痛和炎症的一种首选方案包括血清素 2 拮抗剂、血清素 3 拮抗剂、组胺拮抗剂、血清素激动剂、环氧化酶抑制剂、神经激肽 1 拮抗剂、神经激肽 2 拮抗剂、嘌呤受体拮抗剂、ATP 敏感性钾通道开放剂、钙通道拮抗剂、缓激肽 1 拮抗剂、缓激肽 2 拮抗剂和阿片激动剂。