2-hydroxymethyl-2-methyl-valeric acid | 15240-86-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-hydroxymethyl-2-methyl-valeric acid
• 英文别名: 3-Hydroxy-2-methyl-2-propyl-propionsaeure；2-Hydroxymethyl-2-methyl-valeriansaeure；2-(Hydroxymethyl)-2-methylpentanoic acid
• CAS: 15240-86-5
• 化学式: C₇H₁₄O₃
• 分子量: 146.186
• InChiKey: METJRNPZJAUAGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-hydroxymethyl-2-methyl-valeric acid 、 乙酸酐 生成 3-Acetoxy-2-methyl-2-propylpropionsaeure
  参考文献：
  名称：

  Merger,F., Chemische Berichte, 1968, vol. 101, p. 2413 - 2418

  摘要：

  DOI：
• 作为产物：
  描述：

  2-甲基-2-丙基-1,3-丙二醇 在 sodium hydroxide 、 potassium permanganate 作用下， 生成 2-hydroxymethyl-2-methyl-valeric acid
  参考文献：
  名称：

  5,5-Disubstituted Dihydro-1,3-oxazine-2,4-diones. Research on Compounds Active on Central Nervous System. XII^1a

  摘要：

  DOI：

  10.1021/jo01094a026

文献信息

• Synthesis of glycols via transfer hydrogenation of alpha-functional esters with alcohols
  申请人：Eastman Chemical Company

  公开号：US10266467B2

  公开（公告）日：2019-04-23

  A transfer hydrogenation process for forming vicinal diols by hydrogenating 1,2-dioxygenated organic compounds using alcohols as the reducing agent instead of the traditional H2 gas. The transfer hydrogenation is carried out under milder conditions of temperature and pressure than is typical for ester hydrogenation with H2. The milder conditions of operation provide benefits, such as lower operating and capital costs for industrial scale production as well as savings in product purification due to the avoidance of by-products from exposure of reaction mixtures and products to high temperatures.

  利用醇类作为还原剂而不是传统的 H2 气体，通过氢化 1,2-二氧 化有机化合物形成沧烷二醇的转移氢化工艺。与使用 H2 进行酯加氢的典型方法相比，转移加氢是在较温和的温度和压力条件下进行的。较温和的操作条件带来了诸多好处，例如降低了工业规模生产的操作和资本成本，以及由于避免了反应混合物和产品暴露于高温而产生的副产品，从而节省了产品提纯费用。
• Polyester containing tertiary carboxyl groups, process for its preparation and thermosetting powder compositions containing it
  申请人：——

  公开号：US20030148130A1

  公开（公告）日：2003-08-07

  The invention concerns a polyester bearing tertiary carboxyl groups, characterised in that it consists of: (a) 8.1 to 35 moles of an aliphatic or cycloaliphatic of a polyol; (b) 9.1 to 36 moles of an aliphatic, cycloaliphatic or aromatic polycarboxylic acid; (c) 1.6 to 2.8 moles of an aliphatic, cycloaliphatic or aromatic compound comprising a tertiary carboxyl group and either a primary or secondary carboxyl group, or a primary or secondary hydroxyl group. Said polyester is prepared in several steps, the first steps consisting in the preparation of a polyester by condensation between (a) an aliphatic or cycloaliphatic polyol, and (b) an aliphatic, cycloaliphatic or aromatic polycarboxylic acid, the final step consisting in condensing said polyester with (c) an aliphatic, cycloaliphatic or aromatic compound comprising a tertiary carboxyl group and either a primary or secondary carboxyl group, or a primary or secondary hydroxyl group. Said polyester is used in thermosetting powder compositions, mixed with a crosslinking agent which is more particularly a &bgr;-hydroxylalkylarnide. Said compositions provide coatings with excellent surface appearance, good flexibility and good resistance to poor weather conditions.

  本发明涉及一种带有叔羧基的聚酯，其特征在于它包括(a) 8.1 至 35 摩尔的脂肪族或环脂族多元醇； (b) 9.1 至 36 摩尔的脂肪族、环脂族或芳香族多元羧酸； (c) 1.6 至 2.8 摩尔的脂肪族、环脂族或芳香族化合物，该化合物包含一个叔羧基和一个伯或 仲羧基，或一个伯或仲羟基。聚酯的制备分为几个步骤，第一步是通过缩合(a)脂肪族或环脂族多元醇和(b)脂肪族、环脂族或芳香族多羧酸制备聚酯，最后一步是将聚酯与(c)脂肪族、环脂族或芳香族化合物缩合，该化合物包含叔羧基和伯、仲羧基，或伯、仲羟基。所述聚酯用于热固性粉末组合物中，并与交联剂混合，交联剂尤其是羟基烷基酰胺。所述组合物提供的涂层具有极佳的表面外观、良好的柔韧性和良好的耐恶劣气候条件性能。
• Responsive microgel and methods related thereto
  申请人：——

  公开号：US20030152623A1

  公开（公告）日：2003-08-14

  A responsive microgel is provided which responds volumetrically and reversibly to a change in one or more aqueous conditions selected from the group consisting of (temperature, pH, and ionic conditions) comprised of an ionizable network of covalently cross-linked homopolymeric ionizable monomers wherein the ionizable network is covalently attached to an amphiphilic copolymer to form a plurality of ‘dangling chains’ and wherein the ‘dangling chains’ of amphiphilic copolymer form immobile micelle-like aggregates in aqueous solution. A responsive microgel is further provided that comprises at least one therapeutic entity and delivers a substantially linear and sustained release of the therapeutic entity under physiological conditions.

  本发明提供了一种响应型微凝胶，该微凝胶可对选自由温度、pH 值和离子条件组成的组中的一种或多种水性条件的变化作出体积上和可逆的响应、和离子条件）组成的共价交联均聚可离子化单体的可离子化网络，其中可离子化网络与两性共聚物共价连接，形成多条 "悬链"，两性共聚物的 "悬链 "在水溶液中形成不动的胶束状聚集体。还提供了一种响应性微凝胶，它包含至少一种治疗实体，并能在生理条件下提供治疗实体的线性和持续释放。
• PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS
  申请人：G.D. Searle & Co.

  公开号：EP0907666A1

  公开（公告）日：1999-04-14
• RESPONSIVE MICROGEL AND METHODS RELATED THERETO
  申请人：SUPRATEK PHARMA, INC.

  公开号：EP1478403A1

  公开（公告）日：2004-11-24