(R)-4-amino-N-(1-(4-chlorophenyl)-4-hydroxybutyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide | 1143533-68-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-4-amino-N-(1-(4-chlorophenyl)-4-hydroxybutyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
• 英文别名: 4-amino-N-[(1R)-1-(4-chlorophenyl)-4-hydroxybutyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
• CAS: 1143533-68-9
• 化学式: C₂₂H₂₇ClN₆O₂
• 分子量: 442.948
• InChiKey: LDSYQXFMCPTTQM-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  120
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-amino-N-(1-(4-chlorophenyl)-4-hydroxybutyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide 生成 (R)-4-amino-N-(1-(4-chlorophenyl)-4-hydroxybutyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide 、 (S)-4-amino-N-(1-(4-chlorophenyl)-4-hydroxybutyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
  参考文献：
  名称：

  [EN] PYRROLO [2, 3 -D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS
  [FR] DÉRIVÉS PYRROLO[2,3-D]PYRIMIDINE COMME INHIBITEURS DE LA PROTÉINE KINASE B

  摘要：

  该发明涉及一类新型化合物，其化学式为（I）或其盐：其中Y、Z1、Z2、R1、R4、R5和n如规范中所述，这些化合物可能在通过蛋白激酶B（PKB）介导的疾病或医疗状况的治疗或预防中有用，例如癌症。该发明还涉及包含所述化合物的药物组合物，使用所述化合物治疗通过PKB介导的疾病的方法，以及制备化合物（I）的方法。

  公开号：

  WO2009047563A1

文献信息

• Novel Protein Kinase B Inhibitors - 060
  申请人：Johnson Paul David

  公开号：US20120190679A1

  公开（公告）日：2012-07-26

  The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z 1 , Z 2 , R 1 , R 4 , R 5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).

  本发明涉及一种新型化合物组，其化学式为（I）或其盐： 其中Y、Z1、Z2、R1、R4、R5和n如规范中所述，可以用于治疗或预防通过蛋白激酶B（PKB）介导的疾病或医疗情况，如癌症。本发明还涉及包含所述化合物的制药组合物，使用所述化合物治疗由PKB介导的疾病的方法以及制备化合物（I）的方法。
• Protein kinase B inhibitors
  申请人：AstraZeneca AB

  公开号：US10059714B2

  公开（公告）日：2018-08-28

  The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).

  本发明涉及一组新型的式 (I) 化合物或其盐类： 其中 Y、Z1、Z2、R1、R4、R5 和 n 如说明书所述，可用于治疗或预防通过蛋白激酶 B (PKB)介导的疾病或病症，如癌症。本发明还涉及包含所述化合物的药物组合物、使用所述化合物治疗由PKB介导的疾病的方法以及制备式(I)化合物的方法。
• Protein Kinase B Inhibitors
  申请人：AstraZeneca AB

  公开号：US20180312516A1

  公开（公告）日：2018-11-01

  The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z 1 , Z 2 , R 1 , R 4 , R 5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).
• PROTEIN KINASE B INHIBITORS
  申请人：AstraZeneca AB

  公开号：US20200239483A1

  公开（公告）日：2020-07-30

  The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z 1 , Z 2 , R 1 , R 4 , R 5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).
• US8101623B2
  申请人：——

  公开号：US8101623B2

  公开（公告）日：2012-01-24