5-trifluoromethyl-2-phenylsulfanyl-3-((methoxycarbonyl)(phenylsulfanyl)methyl)-1H-indole | 1295558-79-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-trifluoromethyl-2-phenylsulfanyl-3-((methoxycarbonyl)(phenylsulfanyl)methyl)-1H-indole
• 英文别名: methyl 2-phenylsulfanyl-2-[2-phenylsulfanyl-5-(trifluoromethyl)-1H-indol-3-yl]acetate
• CAS: 1295558-79-0
• 化学式: C₂₄H₁₈F₃NO₂S₂
• 分子量: 473.54
• InChiKey: QZBKEVBEDOKSGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  92.7
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  N-(4-(trifluoromethyl)phenyl)formamide 在 联苯二碲 、 palladium diacetate 、 三乙胺 、 二异丙胺 、 三(邻甲基苯基)磷 、 三氯氧磷 作用下， 以 氯仿 、 乙腈 为溶剂， 反应 42.0h， 生成 5-trifluoromethyl-2-phenylsulfanyl-3-((methoxycarbonyl)(phenylsulfanyl)methyl)-1H-indole
  参考文献：
  名称：

  Photoinduced Intramolecular Cyclization of o-Ethenylaryl Isocyanides with Organic Disulfides Mediated by Diphenyl Ditelluride

  摘要：

  Photoinduced reaction of o-ethenylaryl isocyanides with organic disulfides in the presence of diphenyl ditellurides affords the corresponding bisthiolated indole derivatives via a radical cyclization process. The cyclization can proceed at room temperature upon visible-light irradiation and exhibits good tolerance to functional groups. Several organic disulfides also can be employed for this cyclization, and the corresponding bisthiolated indole derivatives are obtained selectively. In addition, the photoinduced reaction of o-ethenylaryl isocyanides with bis(2-aminophenyl) disulfide affords tetracyclic compounds in one portion.

  DOI：

  10.1021/jo200299d

文献信息

• Photoinduced Intramolecular Cyclization of <i>o</i>-Ethenylaryl Isocyanides with Organic Disulfides Mediated by Diphenyl Ditelluride
  作者：Takenori Mitamura、Kimiyo Iwata、Akiya Ogawa

  DOI：10.1021/jo200299d

  日期：2011.5.20

  Photoinduced reaction of o-ethenylaryl isocyanides with organic disulfides in the presence of diphenyl ditellurides affords the corresponding bisthiolated indole derivatives via a radical cyclization process. The cyclization can proceed at room temperature upon visible-light irradiation and exhibits good tolerance to functional groups. Several organic disulfides also can be employed for this cyclization, and the corresponding bisthiolated indole derivatives are obtained selectively. In addition, the photoinduced reaction of o-ethenylaryl isocyanides with bis(2-aminophenyl) disulfide affords tetracyclic compounds in one portion.