dimethyl-p-hydroxyphenyl phosphate | 1665-78-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dimethyl-p-hydroxyphenyl phosphate
• 英文别名: 4-hydroxyphenyl dimethyl phosphate；Phosphorsaeure-dimethyl-p-hydroxy-phenylester；O,O-Dimethyl-O-(4-hydroxy-phenyl)-phosphonat；O,O-Dimethyl-O-p-hydroxyphenyl-phosphat；Dimethyl-<4-hydroxy-phenyl>-phosphat；phosphoric acid, 4-hydroxyphenyl dimethyl ester；Dimethyl-(4-hydroxy-phenyl)-phosphat；Dimethyl-p-hydroxyphenylphosphat；(4-Hydroxyphenyl) dimethyl phosphate
• CAS: 1665-78-7
• 化学式: C₈H₁₁O₅P
• 分子量: 218.146
• InChiKey: LGFLACTWZXPCCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  dimethyl-p-hydroxyphenyl phosphate 在 三甲胺 作用下， 以 丙酮 为溶剂， 生成 Methyl-p-hydroxyphenylphosphat
  参考文献：
  名称：

  Jentzsch,R. et al., Journal fur praktische Chemie (Leipzig 1954), 1975, vol. 317, p. 721 - 732

  摘要：

  DOI：
• 作为产物：
  描述：

  对苯醌 、 亚磷酸氢二甲酯 以10%的产率得到
  参考文献：
  名称：

  TRUTNEVA, E. K.;LEVIN, YA. A., IZV. AN CCCP. CEP. XIM., 1983, N 7, 1684

  摘要：

  DOI：

文献信息

• Synthesis and structure-activity relationship of furoquinolinediones as inhibitors of Tyrosyl-DNA phosphodiesterase 2 (TDP2)
  作者：Le-Mao Yu、Zhu Hu、Yu Chen、Azhar Ravji、Sophia Lopez、Caroline B. Plescia、Qian Yu、Hui Yang、Monica Abdelmalak、Sourav Saha、Keli Agama、Evgeny Kiselev、Christophe Marchand、Yves Pommier、Lin-Kun An

  DOI：10.1016/j.ejmech.2018.04.024

  日期：2018.5

  Tyrosyl-DNA phosphodiesterase 2 (TDP2) is a recently discovered enzyme specifically repairing topoisomerase II (TOP2)-mediated DNA damage. It has been shown that inhibition of TDP2 synergize with TOP2 inhibitors. Herein, we report the discovery of the furoquinolinedione chemotype as a suitable skeleton for the development of selective TDP2 inhibitors. Compound 1 was identified as a TDP2 inhibitor as a result

  酪氨酰-DNA磷酸二酯酶2（TDP2）是最近发现的一种酶，可特异性修复拓扑异构酶II（TOP2）介导的DNA损伤。已经显示出对TDP2的抑制与TOP2抑制剂协同作用。在此，我们报告了呋喃喹啉二酮化学型作为开发选择性TDP2抑制剂的合适骨架的发现。通过筛选内部化合物库中对TDP2和TDP1有选择性的化合物，化合物1被确定为TDP2抑制剂。进一步的SAR研究提供了几种在低微摩尔范围内的选择性TDP2抑制剂。最有效的化合物74对全细胞提取物（WCE）中的重组TDP2和TDP2表现出抑制活性，IC50分别为1.9和2.1μM。
• Highly Selective 1,4- and 1,6-Addition of P(O)H Compounds to<i>p</i>-Quinones: A Divergent Method for the Synthesis of<i>C</i>- and<i>O</i>-Phosphoryl Hydroquinone Derivatives
  作者：Biquan Xiong、Ruwei Shen、Midori Goto、Shuang-Feng Yin、Li-Biao Han

  DOI：10.1002/chem.201202074

  日期：2012.12.21

  functionality. Further studies on these reactions by using optically active H‐phosphinates showed that all addition reactions took place stereospecifically with retention of configuration at the phosphorus center. The findings lead to the establishment of a divergent method for the synthesis of C‐ and O‐phosphoryl hydroquinone derivatives from easily available P(O)H compounds.

  P的反应（O） H的化合物与p -quinones可以继续通过任1,4-或通过使用不同的添加剂，以1,6-加成途径选择性地得到良好的收率相应C-和O-磷酰基氢醌衍生物。P（O）H化合物向p的氧化双1,4-加成还可以通过调节溶剂来获得对苯二酚，从而轻松合成具有磷官能团的双取代对苯二酚。通过使用旋光性H-次膦酸酯对这些反应的进一步研究表明，所有加成反应均发生立体定向，并且在磷中心保留了构型。这些发现导致建立了一种从容易获得的P（O）H化合物合成C-和O-磷酰基氢醌衍生物的方法。
• G-addition of dimethyl phosphite to p-benzoquinone
  作者：E. K. Trutneva、Ya. A. Levin

  DOI：10.1007/bf00954384

  日期：1983.7
• METHOD FOR PURIFYING POLYMER AND POLYMER
  申请人：Sunaga Tadahiro

  公开号：US20120208976A1

  公开（公告）日：2012-08-16

  Disclosed is a method for purifying a polymer in which a solution containing a cyclic olefin polymer having at least a repeating structural unit [A] represented by the general formula (1) and a metal component is brought into contact with an organic compound having a basic functional group and an acidic functional group, and then the resulting solution is brought into contact with a basic adsorbent to remove the metal component contained in the solution.
• US8450440B2
  申请人：——

  公开号：US8450440B2

  公开（公告）日：2013-05-28