trans-2-hydroxymethyl-4-(cytosin-1'-yl)-1,3-dioxolane | 141196-85-2

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 英文名称: trans-2-hydroxymethyl-4-(cytosin-1'-yl)-1,3-dioxolane
• 英文别名: 4-amino-1-[(2R,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]pyrimidin-2-one
• CAS: 141196-85-2
• 化学式: C₈H₁₁N₃O₄
• 分子量: 213.193
• InChiKey: RXRGZNYSEHTMHC-NKWVEPMBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  97.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-溴-4'-硝基苯乙酮 、 trans-2-hydroxymethyl-4-(cytosin-1'-yl)-1,3-dioxolane 以 甲醇 为溶剂， 以74%的产率得到6-((2R,4S)-2-Hydroxymethyl-[1,3]dioxolan-4-yl)-2-(4-nitro-phenyl)-6H-imidazo[1,2-c]pyrimidin-5-one
  参考文献：
  名称：

  Discovery of imidazo[1,2-c]pyrimidin-5(6H)-one heterosubstituted nucleoside analogues with potent activity against human hepatitis B virus in vitro

  摘要：

  The in vitro antihepatitis B virus (HBV) activities of eleven novel imidazo[1,2-c]pyrimidin-5(6H)-one dideoxynucleoside analogues in which the sugar ring is 1,3-dioxolane or 1,3-oxathiolane were compared in the chronically HBV-producing human cell line 2.2.15. Seven nucleoside analogues 4, 9, 10, 15, 16, Is, and 24, of which 16 possesses the tra,ls relative stereochemistry, displayed good potency and selectivity towards HBV. The order of decreasing potency at the 90% extracellular DNA inhibition level was 15>16>24 approximate to 9>10>18. None of the tested imidazo[1,2-c]pyrimidines inhibited the replication of HIV-1 in MT-4 cells. (C) 1997, Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00001-2
• 作为产物：
  描述：

  trans-2-benzoyloxymethyl-4-(N-acetylcytosin-1'-yl)-1,3-dioxolane 在 potassium carbonate 作用下， 以 甲醇 为溶剂， 生成 trans-2-hydroxymethyl-4-(cytosin-1'-yl)-1,3-dioxolane
  参考文献：
  名称：

  2-Substituted-4-substituted-1,3-dioxolanes and use thereof

  摘要：

  含有1,3-二氧杂环戊烷结构的核苷类似物是适用的抗病毒药物，特别适用于治疗哺乳动物，尤其是人类的HIV感染。核苷类似物的例子包括：顺式-2-乙酰氧甲基-4-(胸腺嘧啶-1'-基)-1,3-二氧杂环戊烷，顺式-2-羟甲基-4-(胸腺嘧啶-1'-基)-1,3-二氧杂环戊烷，顺式-2-苯甲酰氧甲基-4-(胞嘧啶-1'-基)-1,3-二氧杂环戊烷，以及顺式-2-羟甲基-4-(胞嘧啶-1'-基)-1,3-二氧杂环戊烷。这些化合物可以是它们的外消旋体或它们的单独对映体形式。

  公开号：

  US06350753B1

文献信息

• Asymmetric synthesis of 1,3-dioxolane-pyrimidine nucleosides and their anti-HIV activity.
  作者：Hea O. Kim、Soon K. Ahn、Antonio J. Alves、J. Warren Beach、Lak S. Jeong、Bo G. Choi、Patrick Van Roey、Raymond F. Schinazi、Chung K. Chu

  DOI：10.1021/jm00089a007

  日期：1992.5

  In order to study the structure-activity relationships of dioxolane nucleosides as potential anti-HIV agents, various enantiomerically pure dioxolane-pyrimidine nucleosides have been synthesized and evaluated against HIV-1 in human peripheral blood mononuclear cells. The enantiomerically pure key intermediate 8 has been synthesized in nine steps from 1,6-anhydro-D-mannose (1), which was condensed with

  为了研究作为潜在抗HIV剂的二氧戊环核苷的构效关系，已经合成了各种对映体纯的二氧戊环-嘧啶核苷，并在人外周血单核细胞中针对HIV-1进行了评估。对映体纯的关键中间体8已经由1，6-脱水-D-甘露糖（1）以9个步骤合成，将其与5-取代的嘧啶缩合以获得各种二氧戊环-嘧啶核苷。对这些化合物进行评估后，发现胞嘧啶衍生物19尽管毒性最高，但仍显示出最有效的抗HIV药物。抗HIV效力的顺序如下：胞嘧啶（β-异构体）大于胸腺嘧啶大于胞嘧啶（α-异构体）大于5-氯尿嘧啶大于5-溴尿嘧啶大于5-氟尿嘧啶衍生物。尿嘧啶 发现5-甲基胞嘧啶和5-碘尿嘧啶衍生物是无活性的。有趣的是，α-异构体20显示出良好的抗HIV活性而没有细胞毒性。如预期的那样，其他α-异构体没有表现出任何显着的抗病毒活性。（-）-Dioxolane-T对AZT耐药病毒的疗效比对AZT敏感的病毒低5倍。
• Oxidative degradation of L-ascorbic acid acetals to 2′,3′-dideoxy-3′-oxaribofuranosides. Synthesis of enantiomerically pure 2′,3′-dideoxy-3′-oxacytidine stereoisomers as potential antiviral agents
  作者：Bernard R. Belleau、Colleen A. Evans、H.L.Allan Tse、Haolun Jin、Dilip M. Dixit、Tarek S. Mansour

  DOI：10.1016/s0040-4039(00)60903-6

  日期：1992.11

  Enantiomerically pure 2′,3′-dideoxy-3′-oxacytidine nucleoside analogues were synthesized from L-ascorbic acid in eight steps and good overall yield.

  对映体纯的2'，3'-二脱氧-3'-氧代胞苷核苷类似物是由L-抗坏血酸分八步合成的，具有良好的总收率。
• Structure-Activity Relationships Among a New Class of Antiviral Heterosubstituted 2',3'-Dideoxynucleoside Analogues
  作者：Tarek Mansour、Haolun Jin、Wei Wang、Dilip Dixit、Colleen Evans、H. L. Allan Tse、Bernard Belleau、John Gillard、Elizabeth Hooker、Claire Ashman、Nick Cammack、Horacio Salomon、Antonietta Belmonte、Mark Wainberg

  DOI：10.1080/15257779508012439

  日期：1995.5.1

  3'-Oxa-4'-thiocytidine nucleoside analogues 14-17 were prepared from oxathiolanes 10 and 11, and evaluated for activity against HIV-1 and HBV in vitro. The nucleoside analogues were found to possess potent activities against HIV-1 in a panel of cell lines. Compound 16 is moderately active against HBV in 2.2.15 cells.