4-(4-acetylphenoxy)benzaldehyde | 872976-91-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-acetylphenoxy)benzaldehyde
• CAS: 872976-91-5
• 化学式: C₁₅H₁₂O₃
• 分子量: 240.258
• InChiKey: UHQURAVRRFLLFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(4-acetylphenoxy)benzaldehyde 在 sodium tetrahydroborate 、 三乙酰氧基硼氢化钠 作用下， 以 甲醇 为溶剂， 生成 (+/-)-(1RS,2SR,3SR,4RS)-4-{{4-{4-[(1RS)-1-hydroxyethyl]phenoxy}benzyl}amino}cyclohex-5-ene-1,2,3-triol and (+/-)-(1RS,2SR,3SR,4RS)-4-{{4-{4-[(1SR)-1-hydroxyethyl]phenoxy}benzyl}amino}cyclohex-5-ene-1,2,3-triol
  参考文献：
  名称：

  （1 S，2 S，3 R，6 R）-6-氨基环己-4-烯-1,2,3-三醇（=（-）-Conduramine B-1）是α-甘露糖苷酶的选择性抑制剂。N-苄基化增强其抑制活性

  摘要：

  （-）-和（+）-Conduramine B-1（（-）-和（+）- 5，分别）衍生自（+）-和（-）-7-氧杂双环[2.2.1]庚烷-5-en-2-one（第一代“裸糖”）。尽管（-）- 5模仿β-葡糖苷的结构，但是它不抑制β-葡糖苷酶，而是选择性地抑制α-甘露糖苷酶。（-）- 5的N-苄基化提高了conduramine B-1作为α-甘露糖苷酶抑制剂的效力，并且还生成了抑制β-葡萄糖苷酶的化合物。例如，（-）- N-苄基-conduramine B-1（（-）- 19a）是β的竞争性抑制剂-来自杏仁（IC 50  = 32μM，K i  = 10μM）的葡萄糖苷酶和来自杰克豆（IC 50  = 171μM）和来自杏仁（IC 50  = 225μM）的α-甘露糖苷酶的弱抑制剂，而（-）- N-（4-苯基苄基）conduramine B-1（（-）- 19g）是来自千斤顶豆的α-甘露糖苷酶的良好抑制剂（IC

  DOI：

  10.1002/hlca.200590220
• 作为产物：
  描述：

  4-hydroxyacetophenone dimethyl acetal 在 盐酸 、 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.5h， 生成 4-(4-acetylphenoxy)benzaldehyde
  参考文献：
  名称：

  （1 S，2 S，3 R，6 R）-6-氨基环己-4-烯-1,2,3-三醇（=（-）-Conduramine B-1）是α-甘露糖苷酶的选择性抑制剂。N-苄基化增强其抑制活性

  摘要：

  （-）-和（+）-Conduramine B-1（（-）-和（+）- 5，分别）衍生自（+）-和（-）-7-氧杂双环[2.2.1]庚烷-5-en-2-one（第一代“裸糖”）。尽管（-）- 5模仿β-葡糖苷的结构，但是它不抑制β-葡糖苷酶，而是选择性地抑制α-甘露糖苷酶。（-）- 5的N-苄基化提高了conduramine B-1作为α-甘露糖苷酶抑制剂的效力，并且还生成了抑制β-葡萄糖苷酶的化合物。例如，（-）- N-苄基-conduramine B-1（（-）- 19a）是β的竞争性抑制剂-来自杏仁（IC 50  = 32μM，K i  = 10μM）的葡萄糖苷酶和来自杰克豆（IC 50  = 171μM）和来自杏仁（IC 50  = 225μM）的α-甘露糖苷酶的弱抑制剂，而（-）- N-（4-苯基苄基）conduramine B-1（（-）- 19g）是来自千斤顶豆的α-甘露糖苷酶的良好抑制剂（IC

  DOI：

  10.1002/hlca.200590220

文献信息

• FAN
  申请人：KAO CORPORATION

  公开号：US20190071554A1

  公开（公告）日：2019-03-07

  A fan containing a polyester resin composition containing a thermoplastic polyester resin (A) constituted of a dicarboxylic acid component and a diol component, including, for example, polybutylene terephthalate resin, polytrimethylene terephthalate resin, polyethylene terephthalate resin, and the like, one or more members selected from the group consisting of plasticizers and elastomers (B), and an inorganic filler (C). Since the fan of the present invention has a short vibration time even while having a high flexural modulus as a structural member, in the manufactured product equipment or apparatus or structured article that generates vibrations or noises, even when a fan is placed in the surroundings of the sources of vibrations or noises, the generated vibrations are damped and consequently excellent effects are exhibited that extraneous vibrations pertaining to properties of manufactured products or apparatus or unpleasant vibrations or vibrating sounds or noises are reduced.
• POLYESTER RESIN MOLDING COMPOSITION FOR DAMPING MATERIALS
  申请人：KAO CORPORATION

  公开号：US20190144661A1

  公开（公告）日：2019-05-16

  A polyester resin molding composition for vibration-damping material containing a thermoplastic polyester resin (A) constituted of a dicarboxylic acid component and a diol component, a plasticizer and/or an elastomer (B), and an inorganic filler (C), wherein the polyester resin molding composition satisfies one or both selected from the following (i) a weight-average molecular weight (Mw) is 50,000 or more and 150,000 or less, and an absolute degree of crystallinity (Xc) is 5% or more; and (ii) a weight-average molecular weight (Mw) is 150,000 or less, and an absolute degree of crystallinity (Xc) is 5% or more and 37% or less. The polyester resin molding composition of the present invention can be suitably used as a vibration-damping material in, for example, manufactured articles, such as materials for audio equipment such as speakers, television, radio cassette recorders, headphones, audio components, or microphones, electric appliances, transportation vehicles, construction buildings, and industrial equipment, or parts or housing thereof.
• POLYESTER RESIN COMPOSITION FOR DAMPING MATERIALS
  申请人：Kao Corporation

  公开号：US20190136044A1

  公开（公告）日：2019-05-09

  A polyester resin composition for vibration-damping material containing a thermoplastic polyester resin (A) constituted of a dicarboxylic acid component and a diol component, a plasticizer (B) represented by the general formula (I): wherein each of A 1 and A 2 is independently an alkyl group having 4 or more carbon atoms and 18 or less carbon atoms, an aralkyl group having 7 or more carbon atoms and 18 or less carbon atoms, or a mono- or diether of a (poly)oxyalkylene adduct thereof; n is 0 or 1; X is any one of —SO 2 —, —O—, —CR 1 R 2 —, and —S—, wherein each of R 1 and R 2 is independently H or an alkyl group having 4 or less carbon atoms, and wherein each of R 3 and R 4 is independently any one of —O—, —CO—, and —CH 2 —, with proviso that a case where both R 3 and R 4 are —O— is excluded, and an inorganic filler (C). The above composition can be suitably used as a vibration-damping material in manufactured articles, such as materials for audio equipment such as speakers, and electric appliances, or parts or housing thereof.
• US4950809A
  申请人：——

  公开号：US4950809A

  公开（公告）日：1990-08-21
• (1S,2S,3R,6R)-6-Aminocyclohex-4-ene-1,2,3-triol (= (−)-Conduramine B-1) Is a Selective Inhibitor ofα-Mannosidases. Its Inhibitory Activity Is Enhanced byN-Benzylation
  作者：Robert Łysek、Catherine Schütz、Pierre Vogel

  DOI：10.1002/hlca.200590220

  日期：2005.10

  (−)- and (+)-Conduramine B-1 ((−)- and (+)-5, resp.) have been derived from (+)- and (−)-7-oxabicyclo[2.2.1]hept-5-en-2-one (‘naked sugars’ of the first generation). Although (−)-5 imitates the structure of β-glucosides, it does not inhibit β-glucosidases but inhibits α-mannosidases selectively. N-Benzylation of (−)-5 improves the potency of conduramine B-1 as α-mannosidase inhibitor and also generates

  （-）-和（+）-Conduramine B-1（（-）-和（+）- 5，分别）衍生自（+）-和（-）-7-氧杂双环[2.2.1]庚烷-5-en-2-one（第一代“裸糖”）。尽管（-）- 5模仿β-葡糖苷的结构，但是它不抑制β-葡糖苷酶，而是选择性地抑制α-甘露糖苷酶。（-）- 5的N-苄基化提高了conduramine B-1作为α-甘露糖苷酶抑制剂的效力，并且还生成了抑制β-葡萄糖苷酶的化合物。例如，（-）- N-苄基-conduramine B-1（（-）- 19a）是β的竞争性抑制剂-来自杏仁（IC 50  = 32μM，K i  = 10μM）的葡萄糖苷酶和来自杰克豆（IC 50  = 171μM）和来自杏仁（IC 50  = 225μM）的α-甘露糖苷酶的弱抑制剂，而（-）- N-（4-苯基苄基）conduramine B-1（（-）- 19g）是来自千斤顶豆的α-甘露糖苷酶的良好抑制剂（IC