苯酰胺,4-氯-N,N-二苯基- | 15732-27-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 苯酰胺,4-氯-N,N-二苯基-
• 英文名称: 4-Chloro-N,N-diphenylbenzamide
• 英文别名: N-(p-Chlorbenzoyl)-diphenylamin
• CAS: 15732-27-1
• 化学式: C₁₉H₁₄ClNO
• 分子量: 307.779
• InChiKey: YYDOBICTMMGPMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  苯酰胺,4-氯-N,N-二苯基- 在 十六烷基三甲基溴化铵 barium dihydroxide 作用下， 以 水 为溶剂， 生成 二苯胺 、 对氯苯甲酸
  参考文献：
  名称：

  Micellar catalysis of the basic hydrolysis of amides. 4. Substituted N,N-diphenyl benzamides

  摘要：

  DOI：

  10.1021/jo00330a029
• 作为产物：
  描述：

  4-chloro-N-phenyl-benzimidic acid phenyl ester 生成 苯酰胺,4-氯-N,N-二苯基-
  参考文献：
  名称：

  Chapman, Journal of the Chemical Society, 1927, p. 1748

  摘要：

  DOI：

文献信息

• A Simple Copper-Catalyzed Synthesis of Tertiary Acyclic Amides
  作者：Emilie Racine、Florian Monnier、Jean-Pierre Vors、Marc Taillefer

  DOI：10.1021/ol200750p

  日期：2011.6.3

  The N-arylation of aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, has been accomplished using a simple and cheap copper catalytic system. The corresponding tertiary acyclic amides, which can be found in numerous biologically active compounds, have been obtained in good to excellent yields.

  已知是不良亲核试剂的芳族和脂族仲无环酰胺的N-芳基化反应已使用简单廉价的铜催化体系完成。在许多生物活性化合物中可以找到相应的叔无环酰胺，其收率很好。
• A SIMPLE PROCEDURE FOR THE CONVERSION OF CARBOXYLIC ACIDS TO THE CORRESPONDING AMIDES
  作者：Ki-Jong Han、Beom Seok Tae、Misoo Kim

  DOI：10.1080/00304940509354888

  日期：2005.4

  with the synthesis of tertiary amides from carboxylic acids, and successful results were only obtained under forcing conditions."-15 Therefore, an efficient conversion of carboxylic acids into tertiary amides is still in demand to synthesize various organic compounds. In continuation to our studies on the use of trichloromethyl chloroformate in organic synthesis,I6 we report herein a mild and convenient

  羧酸转化为相应的酰胺是有机合成中重要的官能团转化。大多数酰胺的制备方法基于活化的羧酸与胺的反应。文献中报道了许多形成酰胺键的方法。2-10 然而，很少有应用涉及从羧酸合成叔酰胺，并且只有在强制条件下才能获得成功的结果。”- 15 因此，仍需要将羧酸有效转化为叔酰胺以合成各种有机化合物。继续我们对氯甲酸三氯甲酯在有机合成中的应用的研究，
• Rearrangement of nitrones to amides using chlor0sulfonyl isocyanate
  作者：Sajan P. Joseph、D.N. Dhar

  DOI：10.1016/s0040-4020(01)96081-8

  日期：1986.1

  Reaction of chlorosulfonyl isocyanate (CSI) with nitrones a-n and a,b has been studied. α, α, N-Triaryl nitrones a-n react with CSI to form the N,N-diaryl arylamides a-n and i-n in good yields. In the case of α-H, α, N-diaryl nitrones a,b however, two compounds viz., the rearranged product a,b and the 1,4-dihydro tetrazines a,b are formed.

  研究了氯磺酰基异氰酸酯（CSI）与硝酮an和a，b的反应。α，α，N-三芳基硝酮的与CSI反应以形成N，N-二芳基芳基酰胺的和以良好的收率英寸 然而，在α-H，α，N-二芳基亚硝基a，b中，形成了两种化合物，即重排产物a，b和1，4-二氢四嗪a，b。
• Removal of an impurity from a mixture with a co-distillant
  申请人：OCCIDENTAL CHEMICAL CORPORATION

  公开号：EP1044948A2

  公开（公告）日：2000-10-18

  Disclosed is a method of removing an acid halide, anhydride, or ester impurity from a mixture with a desired product with which it codistills. At least about a stoichiometric amount of a primary or secondary amine having a boiling point at least 10°C higher or lower than the boiling point of said desired product is added to the mixture. The desired product is not an acid halide, anhydride, or ester and does not react with the amine. The amine forms a reaction product with the impurity that has a boiling point at least 10°C higher or lower than the boiling point of the desired product. The mixture is distilled to isolate the desired product.

  本发明公开了一种从混合物中去除酸卤化物、酸酐或酯类杂质的方法，混合物中含有与之共蒸馏的所需产品。在混合物中加入至少约等比量的伯胺或仲胺，其沸点比所述所需产品的沸点高或低至少 10°C。所需的产物不是酸卤、酸酐或酯，不会与胺发生反应。胺与杂质形成反应产物，其沸点比所需产物的沸点高或低至少 10°C。对混合物进行蒸馏，分离出所需产物。
• Tang, Xiaorong; Chen, Shaoling; Wang, Ling, Asian Journal of Chemistry, 2012, vol. 24, # 6, p. 2516 - 2518
  作者：Tang, Xiaorong、Chen, Shaoling、Wang, Ling

  DOI：——

  日期：——