6-acetyl-4-(4-fluorophenyl)-2-ethylamino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine | 144507-11-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-acetyl-4-(4-fluorophenyl)-2-ethylamino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
• 英文别名: 1-[2-(ethylamino)-4-(4-fluorophenyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]ethanone
• CAS: 144507-11-9
• 化学式: C₁₇H₁₉FN₄O
• 分子量: 314.362
• InChiKey: KIMWIRDRKKBLBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  58.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-acetyl-4-(4-fluorophenyl)-2-ethylamino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine 生成 2-Ethylamino-4-(4-fluorophenyl)5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine Monohydrochloride
  参考文献：
  名称：

  4-phenyl tetrahydropyrido(4,3-d)pyrimidines

  摘要：

  本文介绍了新型四氢吡啶并[4,3-d]嘧啶类化合物及其合成方法。这些化合物可用于治疗胃肠疾病，特别是作为细胞保护剂以预防溃疡形成。

  公开号：

  US05137890A1
• 作为产物：
  描述：

  N-乙酰基-4-哌啶酮 在 盐酸 、 sodium ethanolate 、 对甲苯磺酸 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 、 甲苯 、 苯 为溶剂， 反应 20.5h， 生成 6-acetyl-4-(4-fluorophenyl)-2-ethylamino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
  参考文献：
  名称：

  Novel tetrahydropyrido[4,3-d]pyrimidines as gastric antilesion agents

  摘要：

  A variety of substituted tetrahydropyrido[4,3-d]pyrimidines was prepared and found to possess gastric antilesion against ethanol-induced lesions in rats. The more potent compounds possessed similar activity against aspirin-induced gastric lesions. A selective group of compounds was determined to be inactive as gastric antisecretory agents in rabbit isolated parietal cells. The antilesion properties of these tetrahydropyrido[4,3-d]pyrimidines make them a potential alternative to prostaglandin therapy for gastric antilesion therapy and may have clinical utility in peptic ulcer disease.

  DOI：

  10.1016/0223-5234(92)90085-f

文献信息

• US5137890A
  申请人：——

  公开号：US5137890A

  公开（公告）日：1992-08-11
• Novel tetrahydropyrido[4,3-d]pyrimidines as gastric antilesion agents
  作者：PJ Sanfilippo、M Urbanski、L Williams、JB Press、LB Katz、DA Shriver、JA Fernandez、D Shatynski、SJ Offord

  DOI：10.1016/0223-5234(92)90085-f

  日期：1992.10

  A variety of substituted tetrahydropyrido[4,3-d]pyrimidines was prepared and found to possess gastric antilesion against ethanol-induced lesions in rats. The more potent compounds possessed similar activity against aspirin-induced gastric lesions. A selective group of compounds was determined to be inactive as gastric antisecretory agents in rabbit isolated parietal cells. The antilesion properties of these tetrahydropyrido[4,3-d]pyrimidines make them a potential alternative to prostaglandin therapy for gastric antilesion therapy and may have clinical utility in peptic ulcer disease.
• 4-phenyl tetrahydropyrido(4,3-d)pyrimidines
  申请人：Ortho Pharmaceutical Corporation

  公开号：US05137890A1

  公开（公告）日：1992-08-11

  ##STR1## Novel tetrahydropyrido[4,3-d]pyrimidines and their synthesis are described. These compounds are useful for the treatment of gastrointestinal diseases, and are particularly useful as cytoprotective agents to prevent ulcer formation.

  本文介绍了新型四氢吡啶并[4,3-d]嘧啶类化合物及其合成方法。这些化合物可用于治疗胃肠疾病，特别是作为细胞保护剂以预防溃疡形成。