3-Bromo-1-methylpyridin-1-ium

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-Bromo-1-methylpyridin-1-ium
• 化学式: C6H7BrN+
• 分子量: 173.03
• InChiKey: HETQOWPCHKBEFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• [EN] MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS<br/>[FR] INHIBITEURS DE PROSTAGLANDINE E SYNTHASE-1 (MPGES1) MICROSOMALE
  申请人：NOVASAID AB

  公开号：WO2011023812A1

  公开（公告）日：2011-03-03

  A compound of formula (I): as well as pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising the compound. The compound is useful for the treatment of disorder selected from inflammatory diseases, nociceptive pain, auto-immune disease, breathing disorders, fever, cancer, inflammation related anorexia, Alzheimer's disease and cardiovascular diseases.

  公式（I）的化合物，以及其药用盐，以及包括该化合物的药物组合物。该化合物用于治疗选择自炎性疾病、伤害性疼痛、自身免疫疾病、呼吸系统疾病、发热、癌症、与炎症相关的厌食症、阿尔茨海默病和心血管疾病的紊乱。
• Characterization of single stranded nucleic acids by melting analysis of secondary structure using double strand-specific nucleic acid dye
  申请人：——

  公开号：US20040033518A1

  公开（公告）日：2004-02-19

  A novel method for characterizing nucleic acids. A nucleic acid is combined with a double stranded nucleic acid-specific dye to form a detectable complex between the dye and one or more double stranded structures within the nucleic acid. The combination is then exposed to varying temperatures and the fluorescence emission of the dye is measured to determine the melting temperature(s) for the double stranded structures. In some embodiments that melting temperature profile is then compared to melting temperature profiles generated for other nucleic acid(s) to discern differences between the compared nucleic acids.

  一种表征核酸的新方法。将核酸与双链核酸特异性染料结合，使染料与核酸中的一个或多个双链结构形成可检测的复合物。然后将该复合物暴露在不同的温度下，测量染料的荧光发射，以确定双链结构的熔化温度。在某些实施方案中，熔化温度曲线会与其他核酸的熔化温度曲线进行比较，以发现比较核酸之间的差异。
• EP1499745A4
  申请人：——

  公开号：EP1499745A4

  公开（公告）日：2006-03-15
• CHARACTERIZATION OF SINGLE STRANDED NUCLEIC ACIDS BY MELTING ANALYSIS OF SECONDARY STRUCTURE USING DOUBLE STRAND-SPECIFIC NUCLEIC ACID DYE
  申请人：University of Utah Research Foundation

  公开号：EP1499745B1

  公开（公告）日：2016-11-23
• SYNTHESIS AND USES OF PYROGLUTAMIC ACID DERIVATIVES
  申请人：Alvarez Builla Gomez Julio

  公开号：US20070249678A1

  公开（公告）日：2007-10-25

  Novel pyroglutamic acid derivatives (I), wherein R 1 is −OH, −ORa, wherein Ra is alkyl, cycloalkyl, alkenyl, cycloalkenyl, aryl, aralkyl or heterocyclyl; R 2 , R 3 and R 4 are independently H, a nitrogen protecting group which hydrolyzes under acidic conditions or phtalamide; X is a pharmaceutically acceptable anion; and Y is a N-containing group; either in the form of their isolated optically active stereoisomers or in the form of mixtures thereof, are useful compounds for enhancing an immuneresponse in a subject and/or for treating tumours, bacterial, fungal or viral infections, or autoimmune diseases.