1,8-di(2-bromomethylphenyl)naphthalene | 1322762-51-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 1,8-di(2-bromomethylphenyl)naphthalene
• 英文别名: 1,8-Bis[2-(bromomethyl)phenyl]naphthalene；1,8-bis[2-(bromomethyl)phenyl]naphthalene
• CAS: 1322762-51-5
• 化学式: C₂₄H₁₈Br₂
• 分子量: 466.215
• InChiKey: GIAABTQEPPSMDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1,8-di(2-bromomethylphenyl)naphthalene 在 aluminum (III) chloride 作用下， 以 二氯甲烷 为溶剂， 以70%的产率得到Hexacyclo[13.7.1.13,22.02,7.09,14.019,23]tetracosa-1(22),2(7),3,5,9,11,13,15,17,19(23),20-undecaene
  参考文献：
  名称：

  New Chiral Cyclooctatriene-Based Polycyclic Architectures

  摘要：

  The synthesis and properties of new chiral polycycllic. architectures that display both helicity and a saddle-type shape are described. The enantiomers have been separated, and their absolute configuration was determined by VCD and ECD. The unprecedented molecular architecture is based on a cyclooctatriene core surrounded by an association of benzo[c]fluorene and ortho-phenylene units.

  DOI：

  10.1021/ol201804h
• 作为产物：
  描述：

  1,8-二溴萘 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 、 N-benzyl-1-phenyl-1-pyrazin-2-ylmethanamine;dichloropalladium 、 caesium carbonate 作用下， 以 四氯化碳 、 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 1,8-di(2-bromomethylphenyl)naphthalene
  参考文献：
  名称：

  New Chiral Cyclooctatriene-Based Polycyclic Architectures

  摘要：

  The synthesis and properties of new chiral polycycllic. architectures that display both helicity and a saddle-type shape are described. The enantiomers have been separated, and their absolute configuration was determined by VCD and ECD. The unprecedented molecular architecture is based on a cyclooctatriene core surrounded by an association of benzo[c]fluorene and ortho-phenylene units.

  DOI：

  10.1021/ol201804h

文献信息

• First expeditious synthesis of 6,11-diamino-[6]carbohelicenes
  作者：Grégory Pieters、Anne Gaucher、Damien Prim、Jérôme Marrot

  DOI：10.1039/b905670j

  日期：——

  The first synthesis of 6,11-diamino-[6]carbohelicenes is described: the short 5 step sequence involves Suzuki–Miyaura coupling, functional group transformations and electrophilic aromatic cyclisation; the original strategy allows the preparation of di- and tetra-substituted helicenes in comfortable yields.

  描述了 6,11-二氨基-[6]碳螺旋烯的首次合成：简短的 5 步序列涉及 Suzuki-Miyaura 偶联、官能团转化和亲电芳香环化；最初的策略允许以舒适的产率制备二取代和四取代的螺旋烯。
• New Chiral Cyclooctatriene-Based Polycyclic Architectures
  作者：Grégory Pieters、Anne Gaucher、Jérôme Marrot、François Maurel、Jean-Valère Naubron、Marion Jean、Nicolas Vanthuyne、Jeanne Crassous、Damien Prim

  DOI：10.1021/ol201804h

  日期：2011.8.19

  The synthesis and properties of new chiral polycycllic. architectures that display both helicity and a saddle-type shape are described. The enantiomers have been separated, and their absolute configuration was determined by VCD and ECD. The unprecedented molecular architecture is based on a cyclooctatriene core surrounded by an association of benzo[c]fluorene and ortho-phenylene units.