(1-Fluorocarbonyl-3-methyl-butyl)-carbamic acid 9H-fluoren-9-ylmethyl ester | 142061-94-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (1-Fluorocarbonyl-3-methyl-butyl)-carbamic acid 9H-fluoren-9-ylmethyl ester
• 英文别名: 9H-fluoren-9-ylmethyl N-(1-fluoro-4-methyl-1-oxopentan-2-yl)carbamate
• CAS: 142061-94-7
• 化学式: C₂₁H₂₂FNO₃
• 分子量: 355.409
• InChiKey: CXINNFBIQRURSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  金刚烷酰氯 、 (1-Fluorocarbonyl-3-methyl-butyl)-carbamic acid 9H-fluoren-9-ylmethyl ester 、 N-Bpoc-4-(3-butenyldimethylsilyl)aniline 、 alkaline earth salt of/the/ methylsulfuric acid 生成 5-Adamantan-1-yl-1-ethyl-3-isobutyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
  参考文献：
  名称：

  A Silicon-Based Linker for Traceless Solid-Phase Synthesis

  摘要：

  DOI：

  10.1021/jo00124a005
• 作为产物：
  描述：

  亮氨酸,N-[(9H-芴-9-基甲氧基)羰基]- 在 吡啶 、 二乙胺基三氟化硫 作用下， 以 二氯甲烷 为溶剂， 反应 0.33h， 生成 (1-Fluorocarbonyl-3-methyl-butyl)-carbamic acid 9H-fluoren-9-ylmethyl ester
  参考文献：
  名称：

  Efficient Loading of Sulfonamide Safety-Catch Linkers by Fmoc Amino Acid Fluorides

  摘要：

  [GRAPHICS]Fmoc-protected amino acid fluorides were found to be excellent reagents for the acylation of sulfonamide safety-catch linkers (SCL) suitable for the subsequent preparation of peptide C-terminal thioesters. High loadings were obtained on different types of resins with low levels of epimerization.

  DOI：

  10.1021/ol0256320

文献信息

• Germanium and Silicon Linking Strategies for Traceless Solid-Phase Synthesis
  作者：Matthew J. Plunkett、Jonathan A. Ellman

  DOI：10.1021/jo961889y

  日期：1997.5.1

  application of germanium and silicon linkage strategies for the solid-phase synthesis of aromatic compounds, as demonstrated for 1,4-benzodiazepine derivatives. The metal-aryl bond that attaches the benzodiazepine to the polymeric support may be cleaved by electrophilic reagents such as H(+) and Br(2) to provide the corresponding substituted derivatives. A number of compounds have been prepared in good overall

  在这里，我们描述了固相合成芳香族化合物的锗和硅键合策略的开发和应用，如针对1,4-苯并二氮杂卓衍生物所证明的。可以通过亲电子试剂（例如H（+）和Br（2））裂解将苯并二氮杂卓连接到聚合物载体上的金属-芳基键，以提供相应的取代衍生物。对于八步法或九步法，已经以高总收率制备了许多化合物。该方法也可以应用于其他种类的芳族化合物库的固相合成。
• Efficient Loading of Sulfonamide Safety-Catch Linkers by Fmoc Amino Acid Fluorides
  作者：Raffaele Ingenito、Dijana Drežnjak、Stefan Guffler、Holger Wenschuh

  DOI：10.1021/ol0256320

  日期：2002.4.1

  [GRAPHICS]Fmoc-protected amino acid fluorides were found to be excellent reagents for the acylation of sulfonamide safety-catch linkers (SCL) suitable for the subsequent preparation of peptide C-terminal thioesters. High loadings were obtained on different types of resins with low levels of epimerization.
• A Silicon-Based Linker for Traceless Solid-Phase Synthesis
  作者：Matthew J. Plunkett、Jonathan A. Ellman

  DOI：10.1021/jo00124a005

  日期：1995.9