7-hydroxycoumarin-4-acetic acid succinimidyl ester | 185102-64-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-hydroxycoumarin-4-acetic acid succinimidyl ester
• 英文别名: N-Succinimidyl 7-hydroxy-4-coumarinyl-acetate；(2,5-dioxopyrrolidin-1-yl) 2-(7-hydroxy-2-oxochromen-4-yl)acetate
• CAS: 185102-64-1
• 化学式: C₁₅H₁₁NO₇
• 分子量: 317.255
• InChiKey: WAXLJIJDTHFUBJ-UHFFFAOYSA-N

物化性质

• 沸点：
  560.0±60.0 °C(Predicted)
• 密度：
  1.61±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  7-hydroxycoumarin-4-acetic acid succinimidyl ester 、 3-(3-氨基丙基)丙酮缩甘油 以 1,4-二氧六环 为溶剂， 反应 5.0h， 生成 C₂₀H₂₅NO₇
  参考文献：
  名称：

  Synthesis of Novel Coumarin-Based Fluorescent Probes

  摘要：

  我们报告了合成适用于特定位置嵌入寡核苷酸的新荧光探针。香豆素衍生物被用作敏感的荧光标记，并通过两种类型的连接剂连接到甘油单元，作为寡核苷酸合成的潜在构建块。测量了功能化香豆素构建块的光谱特性。

  DOI：

  10.1135/cccc20070996
• 作为产物：
  描述：

  N-羟基丁二酰亚胺 、 7-羟基香豆素-4-乙酸 在 N,N'-二环己基碳二亚胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 4.0h， 生成 7-hydroxycoumarin-4-acetic acid succinimidyl ester
  参考文献：
  名称：

  Synthesis of Novel Coumarin-Based Fluorescent Probes

  摘要：

  我们报告了合成适用于特定位置嵌入寡核苷酸的新荧光探针。香豆素衍生物被用作敏感的荧光标记，并通过两种类型的连接剂连接到甘油单元，作为寡核苷酸合成的潜在构建块。测量了功能化香豆素构建块的光谱特性。

  DOI：

  10.1135/cccc20070996

文献信息

• Labeled substrate conjugates for identifying enzyme inhibitors
  申请人：Ying Laiqiang

  公开号：US20060057658A1

  公开（公告）日：2006-03-16

  This invention provides labeled-substrate conjugates for assaying enzymes, particularly neuraminidases. Also provided are assays that are useful for identifying compounds that inhibit sialyltransferases or neuraminidases and may be useful in treating subjects with influenza. In particular, the present invention relates to methods of using such labeled substrate conjugates to screen for enzyme inhibitors, particularly in a high-throughput format.

  本发明提供了用于测定酶的标记底物结合物，特别是神经氨酸酶。还提供了用于鉴定抑制唾液酸转移酶或神经氨酸酶的化合物的测定方法，并可用于治疗患有流感的受试者。特别是，本发明涉及使用这种标记底物结合物在高通量格式中筛选酶抑制剂的方法。
• Syntheses and biological activities of fluorescent-labeled analogs of acylpolyamine toxin NPTX-594 isolated from the venom of Madagascar Joro spider
  作者：Takahiro Nishimaru、Masako Sano、Yoshihiro Yamaguchi、Tateaki Wakamiya

  DOI：10.1016/j.bmc.2008.11.029

  日期：2009.1

  Acylpolyamine-type spider toxins are known to be potent and specific blockers against glutamate receptors (GluRs). The present study describes the syntheses and biological activities of several fluorescent-labeled analogs related to a Madagascar Joro spider toxin NPTX-594 to analyze visually the unknown interaction between spider toxins and GluRs. (c) 2008 Elsevier Ltd. All rights reserved.
• SELF INDICATING RADIATION ALERT DOSIMETER
  申请人：Patel Gordhabhai N.

  公开号：US20120205591A1

  公开（公告）日：2012-08-16

  Described is a self-indicating instant radiation dosimeter ( 1001 ) for monitoring high energy radiations, such as X-ray. The dosimeter contains a radiation sensitive, color changing, indicating composition ( 10 ), e.g., a diacetylene (R—C≡C—C≡C—R′, where R and R′ are substituents groups) or a radiochromic dye, a polymeric binder ( 20 ) and optionally a shelf life extender ( 50 ) or an activator ( 40 ). The radiation sensitive composition ( 10 ) changes color instantly when exposed to high energy radiation. The dose is estimated by comparing the color with a color reference chart or more accurately with a spectrophotometer or an optical densitometer. The radiation sensitive composition ( 10 ) is protected from low energy radiation such as UV light, by a layer of low energy absorbing materials, such as UV absorbers.
• US7527934B2
  申请人：——

  公开号：US7527934B2

  公开（公告）日：2009-05-05
• Synthesis of Novel Coumarin-Based Fluorescent Probes
  作者：Ivana Kosiova、Pavol Kois

  DOI：10.1135/cccc20070996

  日期：——

  We report on synthesis of new fluorescent probes suitable for site-specific incorporation into oligonucleotides. Coumarin derivatives were used as sensitive fluorescent labels and were attached to glycerol unit by two types of linkers as potential building blocks for oligonucleotide synthesis. Spectral characteristics of the functionalized coumarin building blocks were measured.

  我们报告了合成适用于特定位置嵌入寡核苷酸的新荧光探针。香豆素衍生物被用作敏感的荧光标记，并通过两种类型的连接剂连接到甘油单元，作为寡核苷酸合成的潜在构建块。测量了功能化香豆素构建块的光谱特性。