6-benzyl-2-methyl-8,8-bis(phenylsulfanyl)oct-1-ene | 222547-37-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 6-benzyl-2-methyl-8,8-bis(phenylsulfanyl)oct-1-ene
• 英文别名: (3-Benzyl-7-methyl-1-phenylsulfanyloct-7-enyl)sulfanylbenzene
• CAS: 222547-37-7
• 化学式: C₂₈H₃₂S₂
• 分子量: 432.694
• InChiKey: HJZCTTQNGDVONI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.2
• 重原子数：
  30
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-benzyl-2-methyl-8,8-bis(phenylsulfanyl)oct-1-ene 在 Cp2Ti(P(OEt)3)2 作用下， 以 四氢呋喃 为溶剂， 以81%的产率得到4-benzyl-1-methylcycloheptene
  参考文献：
  名称：

  Ring-Closing Metathesis of Titanium–Carbene Complexes Prepared from Thioacetals Having a Carbon–Carbon Double Bond

  摘要：

  The ring-closing metathesis proceeded to give cycloalkenes in good yields when diphenyl thioacetals having a carbon-carbon double bond were treated with the low-valent titanium species Cp2Ti[P(OEt)(3)](2) in THF at room temperature and then at reflux. This methodology is successfully applied to the preparation of cyclic ethers and sulfides. (C) 2000 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(00)00201-5
• 作为产物：
  描述：

  2-Benzyl-6-methyl-hept-6-en-1-ol 在 吡啶 、 正丁基锂 、 sodium iodide 作用下， 以 四氢呋喃 、 正己烷 、 丙酮 为溶剂， 反应 0.25h， 生成 6-benzyl-2-methyl-8,8-bis(phenylsulfanyl)oct-1-ene
  参考文献：
  名称：

  Ring-Closing Metathesis of Titanium–Carbene Complexes Prepared from Thioacetals Having a Carbon–Carbon Double Bond

  摘要：

  The ring-closing metathesis proceeded to give cycloalkenes in good yields when diphenyl thioacetals having a carbon-carbon double bond were treated with the low-valent titanium species Cp2Ti[P(OEt)(3)](2) in THF at room temperature and then at reflux. This methodology is successfully applied to the preparation of cyclic ethers and sulfides. (C) 2000 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(00)00201-5

文献信息

• Titanocene(II)-Promoted Cyclization of Unsaturated Thioacetals
  作者：Tooru Fujiwara、Takeshi Takeda

  DOI：10.1055/s-1999-2618

  日期：1999.3

  The low-valent titanium species-promoted transformation of unsaturated thioacetals to cyclic compounds was studied. The cyclization of thioacetals having an olefin moiety proceeded with the loss of terminal olefin carbon to produce the corresponding five-, six-, and seven-membered cycloalkenes when they were treated with the low-valent titanium species Cp2Ti[P(OEt)3]2 in refluxing THF. The similar reactions of 1-[3,3-bis(phenylthio)propoxy]-2-(prop-1- and prop-2-enyl)benzenes gave the seven- and eight-membered unsaturated cyclic ethers, respectively.

  研究了低价钛物种促进不饱和硫代乙醛向环状化合物的转化。当具有烯烃分子的硫代乙醛在回流四氢呋喃中被低价钛金属 Cp2Ti[P(OEt)3]2 处理时，其环化反应在失去末端烯烃碳的情况下进行，生成相应的五元、六元和七元环烯烃。1-[3,3-双（苯硫基）丙氧基]-2-（丙-1-和丙-2-烯基）苯的类似反应分别生成了七元和八元不饱和环醚。
• Ring-Closing Metathesis of Titanium–Carbene Complexes Prepared from Thioacetals Having a Carbon–Carbon Double Bond
  作者：Tooru Fujiwara、Yoshiko Kato、Takeshi Takeda

  DOI：10.1016/s0040-4020(00)00201-5

  日期：2000.7

  The ring-closing metathesis proceeded to give cycloalkenes in good yields when diphenyl thioacetals having a carbon-carbon double bond were treated with the low-valent titanium species Cp2Ti[P(OEt)(3)](2) in THF at room temperature and then at reflux. This methodology is successfully applied to the preparation of cyclic ethers and sulfides. (C) 2000 Published by Elsevier Science Ltd.