2-Methyl-5-oxo-4-phenyl-5,8-dihydro-pyrido[2,3-d]pyrimidine-7-carboxylic acid methyl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-Methyl-5-oxo-4-phenyl-5,8-dihydro-pyrido[2,3-d]pyrimidine-7-carboxylic acid methyl ester
• 英文别名: methyl 2-methyl-5-oxo-4-phenyl-8H-pyrido[2,3-d]pyrimidine-7-carboxylate
• 化学式: C₁₆H₁₃N₃O₃
• 分子量: 295.298
• InChiKey: RQKQSWMNZUOPEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  81.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  sodium methylate 、 草酸二乙酯 、 4-amino-5-acetyl-2-methyl-4-phenylpyrimidine 以 甲醇 为溶剂， 以50%的产率得到2-Methyl-5-oxo-4-phenyl-5,8-dihydro-pyrido[2,3-d]pyrimidine-7-carboxylic acid methyl ester
  参考文献：
  名称：

  摘要：

  A method for the synthesis of methyl and ethyl 2-R-1-4-R-2-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-7-carboxylates was proposed. The method is based on condensation of 2-R-1-6-R-2-5-acetyl-4-aminopyrimidines with ethyl oxalate in the presence of MeONa or EtONa. Products of the Friedlander self-condensation of the starting pyrimidines were also obtained.

  DOI：

  10.1023/a:1021304619076

文献信息

• ——
  作者：A. V. Komkov、V. A. Dorokhov

  DOI：10.1023/a:1021304619076

  日期：——

  A method for the synthesis of methyl and ethyl 2-R-1-4-R-2-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-7-carboxylates was proposed. The method is based on condensation of 2-R-1-6-R-2-5-acetyl-4-aminopyrimidines with ethyl oxalate in the presence of MeONa or EtONa. Products of the Friedlander self-condensation of the starting pyrimidines were also obtained.