2,3:6,7-diepoxy-2,7-dimethyl-3,6-di(p-tolylsulfinyl)octane | 474304-46-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3:6,7-diepoxy-2,7-dimethyl-3,6-di(p-tolylsulfinyl)octane
• 英文别名: (2R)-2-[2-[(2S)-3,3-dimethyl-2-[(S)-(4-methylphenyl)sulfinyl]oxiran-2-yl]ethyl]-3,3-dimethyl-2-[(R)-(4-methylphenyl)sulfinyl]oxirane
• CAS: 474304-46-6
• 化学式: C₂₄H₃₀O₄S₂
• 分子量: 446.632
• InChiKey: INKWVUAFHDIYJO-BMAQFFHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  97.6
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,3:6,7-diepoxy-2,7-dimethyl-3,6-di(p-tolylsulfinyl)octane 在 sodium hydride 、 间氯过氧苯甲酸 作用下， 以 乙醇 、 二氯甲烷 、 甲苯 为溶剂， 反应 5.5h， 生成 2,7-dimethylocta-1,7-diene-3,6-dione
  参考文献：
  名称：

  A synthesis of diketones from carbonyl compounds and α,ω-dichloro-α,ω-disulfinylalkanes with two carbon–carbon bond-formation via bis-sulfinyloxiranes

  摘要：

  Bis-sulfinyloxiranes were synthesized in two steps from carbonyl compounds and alpha,omega-dichloro-alpha,omega-disulfinylalkanes, which were synthesized from alpha,omega-dibromoalkanes in three steps, in good yields. Treatment of the bis-sulfinyloxiranes with sodium benzenethiolate and piperidine gave alpha,alpha'-di(phenylthio) diketones and alpha,alpha'-diamino diketones, respectively, in high yields. From these products, some kinds of diketones were synthesized in good to high yields. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00352-6
• 作为产物：
  描述：

  1,4-dichloro-1,4-di(p-tolylsulfinyl)butane 在 potassium tert-butylate 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 叔丁醇 为溶剂， 反应 0.84h， 生成 2,3:6,7-diepoxy-2,7-dimethyl-3,6-di(p-tolylsulfinyl)octane
  参考文献：
  名称：

  A synthesis of diketones from carbonyl compounds and α,ω-dichloro-α,ω-disulfinylalkanes with two carbon–carbon bond-formation via bis-sulfinyloxiranes

  摘要：

  Bis-sulfinyloxiranes were synthesized in two steps from carbonyl compounds and alpha,omega-dichloro-alpha,omega-disulfinylalkanes, which were synthesized from alpha,omega-dibromoalkanes in three steps, in good yields. Treatment of the bis-sulfinyloxiranes with sodium benzenethiolate and piperidine gave alpha,alpha'-di(phenylthio) diketones and alpha,alpha'-diamino diketones, respectively, in high yields. From these products, some kinds of diketones were synthesized in good to high yields. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00352-6

文献信息

• A synthesis of diketones from carbonyl compounds and α,ω-dichloro-α,ω-disulfinylalkanes with two carbon–carbon bond-formation via bis-sulfinyloxiranes
  作者：Tsuyoshi Satoh、Daisaku Taguchi、Aki Kurabayashi、Makiko Kanoto

  DOI：10.1016/s0040-4020(02)00352-6

  日期：2002.5

  Bis-sulfinyloxiranes were synthesized in two steps from carbonyl compounds and alpha,omega-dichloro-alpha,omega-disulfinylalkanes, which were synthesized from alpha,omega-dibromoalkanes in three steps, in good yields. Treatment of the bis-sulfinyloxiranes with sodium benzenethiolate and piperidine gave alpha,alpha'-di(phenylthio) diketones and alpha,alpha'-diamino diketones, respectively, in high yields. From these products, some kinds of diketones were synthesized in good to high yields. (C) 2002 Elsevier Science Ltd. All rights reserved.