N-乙基-N-丙基氯甲酰胺 | 98456-61-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-乙基-N-丙基氯甲酰胺
• 英文名称: N-ethyl-N-propylcarbamoyl chloride
• 英文别名: N-ethyl-N-n-propyl carbamoylchloride；N-ethyl-N-propylcarbamoylchloride
• CAS: 98456-61-2
• 化学式: C₆H₁₂ClNO
• 分子量: 149.62
• InChiKey: ZTBGJRUHDDPDEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,5-(CH3)2-4-CH3S-C6H2OH 、 N-乙基-N-丙基氯甲酰胺 以 吡啶 为溶剂， 生成 (2,5-dimethyl-4-methylsulfanylphenyl) N-ethyl-N-propylcarbamate
  参考文献：
  名称：

  DE2814453

  摘要：

  公开号：

文献信息

• Tetrazolinones as herbicides and intermediates
  申请人：NIHON BAYER AGROCHEM K.K.

  公开号：EP0820994A1

  公开（公告）日：1998-01-28

  The present invention relates to novel compounds and mixtures of geometrical isomers, which are represented by the formula: wherein R1 and R2independently of one another are C1-6 alkyl, C1-6 haloalkyl, C3-8 cycloalkyl, C2-6 alkenyl, C2-6 haloalkenyl, C3-6 alkynyl or optionally substituted phenyl; or R1 and R2, together with the nitrogen atom to which they are bonded, form a 5-membered or 6-membered heterocyclic ring which may be benzo-fused or which may be substituted by halogen or C1-4 alkyl; R3 is hydrogen or C1-6 alkyl; R4 is hydrogen or C1-6 alkyl; or R3 and R4, together with the carbon atoms to which they are bonded, form cyclopentylidene or cyclohexylidene; and R5 is C1-6 alkyl, C3-6 alkenyl or benzyl; further to processes and new intermediates for their production and to their use as herbicides.

  本发明涉及一类新的化合物及几何异构体的混合物，其由以下公式表示：其中R1和R2彼此独立地为C1-6烷基，C1-6卤代烷基，C3-8环烷基，C2-6烯基，C2-6卤代烯基，C3-6炔基或可选地被取代的苯基；或者R1和R2与它们所连接的氮原子一起形成一个可能被苯并环合的、5成员或6成员的杂环环，该环可能被卤素或C1-4烷基取代；R3是氢或C1-6烷基；R4是氢或C1-6烷基；或者R3和R4与它们所连接的碳原子一起形成环戊基亚基或环己基亚基；并且R5是C1-6烷基，C3-6烯基或苄基；进一步涉及到它们的制备过程和新中间体，以及它们作为除草剂的使用。
• [EN] METABOTROPIC GLUTAMATE RECEPTOR MODULATORS<br/>[FR] MODULATEURS DES RÉCEPTEURS GLUTAMATERGIQUES MÉTABOTROPES
  申请人：MERZ PHARMA GMBH & CO KGAA

  公开号：WO2012085167A1

  公开（公告）日：2012-06-28

  The invention relates to heterocyclic derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are m GluR5 modulators and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.

  这项发明涉及杂环衍生物及其药用可接受的盐。该发明还涉及一种制备这类化合物的方法。该发明的化合物是mGluR5调节剂，因此对于控制和预防急性和/或慢性神经系统疾病是有用的。
• 7-SUBSTITUTED SULFONIMIDOYLPURINONE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF LIVER CANCER
  申请人：Hoffmann-La Roche Inc.

  公开号：US20200268762A1

  公开（公告）日：2020-08-27

  The present invention relates to compounds of formula (I), wherein R 1 , R 2 and R 3 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, for (use in) the treatment and/or prophylaxis of liver cancer.

  本发明涉及式(I)的化合物，其中R1、R2和R3如本文所述，并且它们的前药或药学上可接受的盐、对映体或二对映体，用于治疗和/或预防肝癌。
• [EN] 7-SUBSTITUTED SULFONIMIDOYLPURINONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION<br/>[FR] COMPOSÉS DE SULFONIMIDOYLPURINONE SUBSTITUÉS DANS LA POSITION 7 POUR LE TRAITEMENT ET LA PROPHYLAXIE D'INFECTION VIRALE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2018041763A1

  公开（公告）日：2018-03-08

  The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds as TLR7 agonists for the treatment of viral infections.

  本发明涉及式(I)的化合物，其中R1、R2和R3如本文所述，以及它们的前药或药用盐、对映体或二对映体，以及包括这些化合物的组合物和使用这些化合物作为TLR7激动剂治疗病毒感染的方法。
• ALKYLOXY SUBSTITUTED THIAZOLOQUINOLINES AND THIAZOLONAPHTHYRIDINES
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US20150266901A1

  公开（公告）日：2015-09-24

  Thiazoloquinolines and thiazolonaphthyridines with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

  本文披露了在6、7、8或9位具有烷氧基取代基的噻唑喹啉和噻唑萘啶类化合物、含有这些化合物的制药组合物、中间体、制备方法以及这些化合物作为免疫调节剂的用途、用于诱导动物细胞因子生物合成和用于治疗包括病毒和肿瘤疾病在内的疾病的方法。