2,2-cyclohexyl-5-[(E)-2-(4-methoxyphenyl)-4-oxo-6-phenylhex-5-enyl]-1,3-dioxane-4,6-dione | 1089672-19-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2,2-cyclohexyl-5-[(E)-2-(4-methoxyphenyl)-4-oxo-6-phenylhex-5-enyl]-1,3-dioxane-4,6-dione
• 英文别名: 3-[(E)-2-(4-methoxyphenyl)-4-oxo-6-phenylhex-5-enyl]-1,5-dioxaspiro[5.5]undecane-2,4-dione
• CAS: 1089672-19-4
• 化学式: C₂₈H₃₀O₆
• 分子量: 462.543
• InChiKey: QFZWVRSKDWJITE-JLHYYAGUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  、 {(1E)-3-[(trimethylsilyl)oxy]buta-1,3-dien-1-yl}benzene 在 scandium tris(trifluoromethanesulfonate) 作用下， 以 二氯甲烷 为溶剂， 以54%的产率得到2,2-cyclohexyl-5-[(E)-2-(4-methoxyphenyl)-4-oxo-6-phenylhex-5-enyl]-1,3-dioxane-4,6-dione
  参考文献：
  名称：

  Sc(OTf)3-catalyzed smooth tandem [3+2] cycloaddition/ring opening of donor–acceptor cyclopropane 1,1-diesters with enol silyl ethers

  摘要：

  Catalyzed by Lewis acids, donor-acceptor cyclopropane 1,1-diesters reacted with enol silyl ethers to afford 1,6-dicarbonyl compounds in moderate to excellent yields. This supplied a mild carbon-carbon bond-forming method from the ring opening of cyclopropanes. A smooth tandem [3+2] cycloaddition/ring opening process has been clearly proved by an independent experiment. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.09.028

文献信息

• Sc(OTf)3-catalyzed smooth tandem [3+2] cycloaddition/ring opening of donor–acceptor cyclopropane 1,1-diesters with enol silyl ethers
  作者：Jie Fang、Jun Ren、Zhongwen Wang

  DOI：10.1016/j.tetlet.2008.09.028

  日期：2008.11

  Catalyzed by Lewis acids, donor-acceptor cyclopropane 1,1-diesters reacted with enol silyl ethers to afford 1,6-dicarbonyl compounds in moderate to excellent yields. This supplied a mild carbon-carbon bond-forming method from the ring opening of cyclopropanes. A smooth tandem [3+2] cycloaddition/ring opening process has been clearly proved by an independent experiment. (C) 2008 Elsevier Ltd. All rights reserved.