N-乙基二氯马来酰亚胺 | 20198-77-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-乙基二氯马来酰亚胺
• 英文名称: N-Ethyl-2,3-dichlor-maleimid
• 英文别名: N-Ethyl-dichlormaleinimid；3,4-dichloro-1-ethyl-pyrrole-2,5-dione；3,4-dichloro-1-ethyl-1H-pyrrole-2,5-dione；3,4-dichloro-N-ethylmaleimide；Maleimide, dichloro-N-ethyl-；3,4-dichloro-1-ethylpyrrole-2,5-dione
• CAS: 20198-77-0
• 化学式: C₆H₅Cl₂NO₂
• mdl: MFCD01716137
• 分子量: 194.017
• InChiKey: UNOAAQSLIJPNKG-UHFFFAOYSA-N

物化性质

• 密度：
  1.3848 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2925190090

反应信息

• 作为反应物：
  描述：

  N-乙基二氯马来酰亚胺 在 lithium aluminium tetrahydride 、 magnesium 、 碘甲烷 作用下， 以 四氢呋喃 为溶剂， 反应 8.0h， 生成
  参考文献：
  名称：

  Rigidized 1-aryl sulfonyl tryptamines: Synthesis and pharmacological evaluation as 5-HT6 receptor ligands

  摘要：

  A series of N-1-arylsulfonyl-3-(pyrrolidin-3-yl)-1H-indole and N-1-arylsulfonyl-3-(4-chloro-2,5-dihydro-1H-pyrrol-3-yl)-1H-indole derivatives (tryptamine derivatives with rigidized side chain) have been prepared and tested for their binding affinity to 5-HT6 receptor. Several compounds displayed potent binding affinity for the 5-HT6 receptor when tested in in vitro binding assay. The primary SAR indicates that rigidification of dimethylamino alkyl chain at C-3 of indole carbon maintains the binding affinity to 5-HT6R. The lead compound N-1-benzenesulfonyl-3-(4-chloro-1-methyl-2,5-dihydro-1H-pyrrol-3-yl)-1H-indole, 10a (K-b = 0.1 nM) has shown excellent in vitro affinity and was active in animal models of cognition like NORT and water maze. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.05.106
• 作为产物：
  描述：

  2,3-二氯马来酸酐 、 乙胺盐酸盐 在 potassium acetate 、 溶剂黄146 作用下， 反应 4.0h， 生成 N-乙基二氯马来酰亚胺
  参考文献：
  名称：

  Rigidized 1-aryl sulfonyl tryptamines: Synthesis and pharmacological evaluation as 5-HT6 receptor ligands

  摘要：

  A series of N-1-arylsulfonyl-3-(pyrrolidin-3-yl)-1H-indole and N-1-arylsulfonyl-3-(4-chloro-2,5-dihydro-1H-pyrrol-3-yl)-1H-indole derivatives (tryptamine derivatives with rigidized side chain) have been prepared and tested for their binding affinity to 5-HT6 receptor. Several compounds displayed potent binding affinity for the 5-HT6 receptor when tested in in vitro binding assay. The primary SAR indicates that rigidification of dimethylamino alkyl chain at C-3 of indole carbon maintains the binding affinity to 5-HT6R. The lead compound N-1-benzenesulfonyl-3-(4-chloro-1-methyl-2,5-dihydro-1H-pyrrol-3-yl)-1H-indole, 10a (K-b = 0.1 nM) has shown excellent in vitro affinity and was active in animal models of cognition like NORT and water maze. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.05.106

文献信息

• [EN] 3,4-DISUBSTITUTED PYRROLE 2,5-DIONES AND THEIR USE AS FUNGICIDES<br/>[FR] (PYRROLE DISUBSTITUÉ EN 3,4)2,5-DIONES ET LEUR UTILISATION COMME FONGICIDES
  申请人：BASF SE

  公开号：WO2012143468A1

  公开（公告）日：2012-10-26

  The present invention relates to the use of 3,4-disubstituted pyrrole 2,5-diones of the formula I as defined in the description for controlling phytopathogenic fungi. Further the invention relates to novel compounds of the formula I.

  本发明涉及使用如描述中定义的式I的3,4-二取代吡咯-2,5-二酮来控制植物病原真菌。此外，本发明还涉及式I的新化合物。
• [EN] COMPOSITIONS AND METHODS FOR VIRAL SENSITIZATION<br/>[FR] COMPOSITIONS ET MÉTHODES DE SENSIBILISATION VIRALE
  申请人：OTTAWA HOSPITAL RES INST

  公开号：WO2016119051A1

  公开（公告）日：2016-08-04

  Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.

  提供了一些化合物，通过增加病毒在细胞中的传播、增加细胞中病毒的滴度或增加病毒中抗原的表达、基因或转基因表达、或细胞中病毒蛋白的表达来增强病毒的功效。还提供了其他用途、组合物和使用方法。
• 3,4-disubstituted pyrrole 2,5-diones and their use as fungicides
  申请人：Riggs Richard

  公开号：US20140045689A1

  公开（公告）日：2014-02-13

  The present invention relates to the use of 3,4-disubstituted pyrrole 2,5-diones of the formula I as defined in the description for controlling phytopathogenic fungi. Further the invention relates to novel compounds of the formula I.

  本发明涉及使用式I中描述的3,4-二取代吡咯-2,5-二酮来控制植物病原真菌。此外，本发明还涉及式I的新化合物。
• Enhancing Dual‐State Emission in Maleimide Fluorophores through Fluorocarbon Functionalisation
  作者：Maria Pervez、Amanda K. Pearce、Jonathan T. Husband、Louise Male、Miquel Torrent‐Sucarrat、Rachel K. O'Reilly

  DOI：10.1002/chem.202201877

  日期：2022.10.18

  A library of trifluoroethyl substituted aminomaleimide derivatives are reported with small size and enhanced emissions in both solution and solid-state. A diCH2CF3 substituted aminochloromaleimide exhibits the most efficient dual-state emission (Φf >50 % in solution and solid-state), with reduced quenching from protic solvents. Hence, these dual-state dyes overcome the limitations of single-state luminescence

  据报道，三氟乙基取代的氨基马来酰亚胺衍生物文库尺寸小，并且在溶液和固态中的发射都增强。二CH 2 CF 3取代的氨基氯代马来酰亚胺表现出最有效的双态发射（溶液和固态中的Φ f >50 %），并且减少了质子溶剂的猝灭。因此，这些双态染料克服了单态发光的局限性，并将成为这一快速发展领域向前迈出的重要一步。
• TRIPHENYLBORANE-ROSIN AMINE ADDUCT AND USE OF THE SAME
  申请人：Yoshitomi Fine Chemicals, Ltd.

  公开号：EP0877061A1

  公开（公告）日：1998-11-11

  The triphenylborane-rosin amine adduct shows superior prevention of adhesion, and thus, antifouling effects against coelenterates such as obelia and hydrozoas; shellfish such as barnacle, blue mussel and oyster, tubicolous polychaetes such as Hydroides norvegica, Serpula vermicularis, Pomatoleios kraussii and Dexiospira spirillum and other aquatic organisms. The concurrent use of 1,3-dicyanotetrachlorobenzene, 2-(thiocyanomethylthio)benzothiazole, tetraalkylthiuramdisulfide, 2,3-dichloromaleimide, phenol, dialkylpolysulfide, polybutene, paraffin or petrolatum, and the above-mentioned compound results in the above-mentioned effects. Thus, the above-mentioned compound can be used to provide a preventive of fouling by the aquatic adhesion organisms, an antifouling agent for a fishnet and an antifouling coating, which have superior antifouling effects against fouling organisms such as coelenterates, shellfish, tubicolous polychaetes and the like.

  三苯硼烷-松香胺加合物具有出色的防附着能力，因此对肠衣纲动物（如 Obelia 和 hydrozoas）、贝类（如藤壶、蓝贻贝和牡蛎）、管状多毛目动物（如 Hydroides norvegica、Serpula vermicularis、Pomatoleios kraussii 和 Dexiospira spirillum）以及其他水生生物具有防污效果。同时使用 1,3-二氰基四氯苯、2-（硫氰基甲硫基）苯并噻唑、四烷基秋兰姆二硫化物、2,3-二氯马来酰亚胺、苯酚、二烷基聚硫、聚丁烯、石蜡或凡士林和上述化合物可产生上述效果。因此，上述化合物可用于提供一种水生附着生物污垢预防剂、一种鱼网防污剂和一种防污涂层，对诸如腔肠动物、贝类、管状多毛类等污垢生物具有卓越的防污效果。