N-乙烯基氧羰基-L-丙氨酸 | 44980-51-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-乙烯基氧羰基-L-丙氨酸
• 英文名称: VOC-Alanin
• 英文别名: N-vinyloxycarbonyl-L-alanine；N-vinyloxycarbonyl alanine；(2S)-2-(ethenoxycarbonylamino)propanoic acid
• CAS: 44980-51-0
• 化学式: C₆H₉NO₄
• 分子量: 159.142
• InChiKey: TZJSRVJKJPOOQV-BYPYZUCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2924199090

文献信息

• POLYMER COMPOSITIONS CONTAINING GRAFTED POLYMERIC NETWORKS AND PROCESSES FOR THEIR PREPARATION AND USE
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：US20180037690A1

  公开（公告）日：2018-02-08

  Provided are polymer compositions made by a process comprising: (a) providing a first reactive composition containing: (i) a polymerization initiator that is capable, upon a first activation, of forming two or more free radical groups, at least one of which is further activatable by subsequent activation; (ii) one or more ethylenically unsaturated compounds; and (iii) a crosslinker; (b) subjecting the first reactive composition to a first activation step such that the first reactive composition polymerizes therein to form a crosslinked substrate network containing a covalently bound activatable free radical initiator, (c) combining the crosslinked substrate network with a second reactive composition containing one or more ethylenically unsaturated compounds; and (d) activating the covalently bound activatable free radical initiator of the crosslinked substrate network such that the second reactive composition polymerizes therein with the crosslinked substrate network to form a grafted polymeric network and a byproduct polymer. Also provided are precursors to the polymer compositions, processes for preparation of the polymer compositions, and methods of using the polymer compositions, for instance in medical devices.

  提供的是由包括以下步骤的过程制备的聚合物组合物：(a)提供含有：(i)能够在第一激活时形成两个或更多自由基团的聚合引发剂，其中至少一个可以通过后续激活进一步激活；(ii)一个或多个乙烯基不饱和化合物；和(iii)交联剂的第一反应组合物；(b)将第一反应组合物暴露于第一激活步骤，使第一反应组合物在其中聚合形成含有共价结合的可激活自由基引发剂的交联基底网络；(c)将交联基底网络与含有一个或多个乙烯基不饱和化合物的第二反应组合物结合；和(d)激活交联基底网络的共价结合的可激活自由基引发剂，使第二反应组合物在其中与交联基底网络聚合形成嵌接聚合物网络和副产物聚合物。还提供了聚合物组合物的前体、制备聚合物组合物的过程以及使用聚合物组合物的方法，例如在医疗器械中的应用。
• IONIC SILICONE HYDROGELS
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：US20130217620A1

  公开（公告）日：2013-08-22

  The present invention relates to ionic silicone hydrogel contact lenses which comprise at least one pharmaceutical or nutriceutical component and are formed from reaction mixtures comprising a mixture of slow-reacting hydrophilic monomers, including at least one slow-reacting ionic monomer, at least one silicone-containing component and at least one hydroxyl-containing component, wherein the ratio of the slow-reacting hydrophilic component half lives to the silicone-containing component half life is at least 2.

  本发明涉及离子硅氢凝胶隐形眼镜，其包括至少一种药用或营养成分，并由反应混合物形成，其包括缓慢反应的亲水性单体的混合物，包括至少一种缓慢反应的离子单体，至少一种含硅组分和至少一种含羟基组分，其中缓慢反应的亲水性组分半衰期与含硅组分半衰期的比率至少为2。
• MEDICAL DEVICES HAVING HOMOGENEOUS CHARGE DENSITY AND METHODS FOR MAKING SAME
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：US20130203813A1

  公开（公告）日：2013-08-08

  The present invention relates to ionic silicone hydrogel polymers comprising at least one pharmaceutical or nutriceutical component and displaying improved lysozyme uptake, low contact angle and reduced water soluble polymeric ammonium salt uptake.

  本发明涉及离子硅氢凝胶聚合物，其中包含至少一种药物或营养成分，并具有改进的溶菌酶摄取、低接触角和减少的可溶性聚合物铵盐摄取。
• Contact lenses with mucin affinity
  申请人：Valint L. Paul

  公开号：US20070116740A1

  公开（公告）日：2007-05-24

  A biomedical device, such as a contact lens, has a surface linked to a polymer comprising boronic acid moieties. The boronic acid monomeric units may be derived from an ethylenically unsaturated monomer containing a boronic acid moiety, such as a vinylphenyl boronic acid or a (meth)acrylamido phenyl boronic acid. The boronic acid moieties may be complexed with mucin, especially epithelial mucin.

  一种生物医学设备，例如隐形眼镜，具有与聚合物连接的表面，该聚合物包含硼酸基团。硼酸单体单位可以来自含有硼酸基团的乙烯基不饱和单体，例如乙烯基苯硼酸或（甲基）丙烯酰胺苯硼酸。硼酸基团可以与黏液结合，特别是上皮黏液。
• Coatings and Solutions for Contact Lenses
  申请人：Vanderbilt David P.

  公开号：US20080151180A1

  公开（公告）日：2008-06-26

  A contact lens is coated with a first polymer, such as a boronic acid-containing copolymer, having affinity to mucin, and a second polymer. The second polymer improves initial comfort of the contact lens. During wear of the contact lens, the second polymer is removed from the contact lens, by blinking and/or tear fluids, and mucin complexes with the first polymer on the contact lens surface.

  隐形眼镜被涂覆了第一种聚合物，例如含有硼酸的共聚物，具有粘附粘液的亲和力，以及第二种聚合物。第二种聚合物提高了隐形眼镜的初始舒适度。在佩戴隐形眼镜期间，第二种聚合物通过眨眼和/或泪液从隐形眼镜上被去除，粘液与隐形眼镜表面的第一种聚合物形成复合物。