(3Z)-6-bromo-3-[3-(hydroxyamino)indol-2-ylidene]-1H-indol-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (3Z)-6-bromo-3-[3-(hydroxyamino)indol-2-ylidene]-1H-indol-2-one
• 化学式: C₁₆H₁₀BrN₃O₂
• 分子量: 356.17
• InChiKey: WNWSUJQVZJJGLF-SQFISAMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  73.7
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• METHOD, COMBINATION AND/OR COMPOSITION FOR INDUCING CARDIOMYOCYTE DIFFERENTATION
  申请人：Singapore Health Services Pte Ltd

  公开号：EP2882848B1

  公开（公告）日：2017-11-01
• Culture of Non-Embryonic Cells at High Cell Density
  申请人：Mays Robert W.

  公开号：US20080194024A1

  公开（公告）日：2008-08-14

  The present invention is directed to the culture of non-embryonic cells, that can differentiate into cell types of more than one embryonic lineage, at high densities in culture under conditions that maintain differentiation capacity during expansion; more particularly, culturing non-embryonic cells at high densities in the presence of a GKS-3 inhibitor, such as BIO.
• Use of a Gsk-3 Inhibitor to Maintain Potency of Culture Cells
  申请人：Mays Robert W.

  公开号：US20080194021A1

  公开（公告）日：2008-08-14

  The present invention is directed to the culture of non-embryonic cells, that can differentiate into cell types of more than one embryonic lineage, in culture under conditions that maintain differentiation capacity during expansion; more particularly, culturing non-embryonic cells in the presence of at least one GKS-3 inhibitor, such as BIO.
• Use of a GSK-3 Inhibitor to Maintain Potency of Cultured Cells
  申请人：Mays Robert W.

  公开号：US20120009674A1

  公开（公告）日：2012-01-12

  The present invention is directed to the culture of non-embryonic cells, that can differentiate into cell types of more than one embryonic lineage, in culture under conditions that maintain differentiation capacity during expansion; more particularly, culturing non-embryonic cells in the presence of at least one GKS-3 inhibitor, such as BIO.
• [EN] USE OF A GSK-3 INHIBITOR TO MAINTAIN POTENCY OF CULTURED CELLS<br/>[FR] EMPLOI D'UN INHIBITEUR DE GSK-3 DANS LE BUT DE CONSERVER LEUR PUISSANCE A DES CELLULES CULTIVEES
  申请人：ATHERSYS INC

  公开号：WO2007016485A2

  公开（公告）日：2007-02-08

  [EN] The present invention is directed to the culture of non-embryonic cells, that can differentiate into cell types of more than one embryonic lineage, in culture under conditions that maintain differentiation capacity during expansion; more particularly, culturing non-embryonic cells in the presence of at least one GKS-3 inhibitor, such as BIO.
  [FR] La présente invention concerne la culture de cellules non embryonnaires capables de se différencier en types de cellules de plus d'une lignée embryonnaire dans des cultures menées dans des conditions qui maintiennent la différenciation pendant l'expansion, et singulièrement la culture de cellules non embryonnaires en présence d'au moins un inhibiteur de GKS-3, tels que BIO.