N-乙酰基-N-(4-甲氧基苯基)乙酰胺 | 3006-35-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-乙酰基-N-(4-甲氧基苯基)乙酰胺
• 英文名称: N-(4-Methoxyphenyl)diacetamide
• 英文别名: 4-methoxy-diacetanilide；p-Methoxy-N,N-diacetanilid；N-(4-Methoxy-phenyl)-diacetamid；N,N-Diacetyl-p-anisidin；N-Acetyl-N-(4-methoxyphenyl)acetamide
• CAS: 3006-35-7
• 化学式: C₁₁H₁₃NO₃
• 分子量: 207.229
• InChiKey: NWBPJGXONLXNMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-乙酰基-N-(4-甲氧基苯基)乙酰胺 在 palladium on activated charcoal 吡啶 、 氢气 、 硝酸 、 乙酸酐 作用下， 以 甲醇 、 乙醇 为溶剂， 20.0 ℃ 、344.74 kPa 条件下， 反应 28.0h， 生成 1,2,3,4-Tetrahydro-quinoxaline-5,8-diamine; compound with GENERIC INORGANIC NEUTRAL COMPONENT
  参考文献：
  名称：

  Synthesis of imidazo[1,5,4-de]quinoxalin-9-ones, benzimidazole analogues of pyrroloiminoquinone marine natural products

  摘要：

  The imidazoquinoxalinones 1 and 2 are benzimidazole analogues of indole-based marine natural products called makaluvamins. The stabilized cation 1 and the zwitterion 2 were prepared in similar to9 steps from readily available starting materials. Compound 1 is more cytostatic and cytotoxic than 2 and also shows activity in the hollow fiber assay. Unlike the indole-based natural products, 1 and 2 are not potent topoisomerase II inhibitors. Their pattern of cytotoxic and cyostatic activity could be related to inhibition of protein tyrosine kinases. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.10.016
• 作为产物：
  描述：

  乙酸酐 、 4'-甲氧基乙酰苯胺 在 吡啶 作用下， 反应 4.0h， 以94.18%的产率得到N-乙酰基-N-(4-甲氧基苯基)乙酰胺
  参考文献：
  名称：

  Ayyangar, Nagaraj R.; Srinivasan, Kumar V., Canadian Journal of Chemistry, 1984, vol. 62, p. 1292 - 1296

  摘要：

  DOI：

文献信息

• Visible-light induced one-pot hydrogenation and amidation of nitroaromatics with carboxylic acids over 2D MXene-derived Pt/N-TiO2/Ti3C2
  作者：Heyan Jiang、Zujie Hu、Chuan Gan、Bin Sun、Shuzhen Kong、Fengxia Bian

  DOI：10.1016/j.mcat.2021.111490

  日期：2021.3

  directional transmission caused by the intimate contact between the TiO2 and the conductive Ti3C2. This direct hydrogenation along with amidation between nitroaromatics and carboxylic acids own actual merits in the amides produce with no harmful byproducts. In situ DRIFTS spectra verified that the amidation activation with visible light irradiation at 25 °C was much faster than heating.

  摘要 负载在 N 掺杂二氧化钛/碳化钛 (MXene) 异质结上的 Pt 纳米粒子被用作光催化剂，用于芳族硝基化合物与羧酸之间的串联反应以生产酰胺产物。3%Pt/N-TiO2/Ti3C2异质结是通过在Ti3C2纳米片上原位生长TiO2，然后用三聚氰胺掺杂N的TiO2，平均直径为3.3 nm的Pt纳米颗粒很好地分散在N-TiO2/Ti3C2上制备的。3%Pt/N-TiO2/Ti3C2在可见光照射下具有优异的酰胺化活性和化学选择性。3%Pt/N-TiO2/Ti3C2 的催化性能提高是由于 TiO2 和导电 Ti3C2 之间的紧密接触引起的电荷短程定向传输提高了光生电子和空穴分离效率。这种直接氢化以及硝基芳烃和羧酸之间的酰胺化在酰胺生产中具有实际优点，并且没有有害的副产物。原位 DRIFTS 光谱验证了在 25°C 下可见光照射的酰胺化活化比加热快得多。
• Process for the production of dis-azo pigment
  申请人：TOYO INK MANUFACTURING CO., LTD.

  公开号：EP0676452A1

  公开（公告）日：1995-10-11

  A process for the production of a dis-azo pigment which process comprises: (a) forming a powder of a dis-azo pigment in air at from 100 to 300°C for up to 0.5 hours from an aqueous paste or slurry of the pigment; and (b) keeping the thus obtained powder at from 50 to 150°C for from 0.5 to 10 hours.

  一种二氮颜料的生产工艺，该工艺包括 (a) 在 100 至 300 摄氏度的空气中，用不超过 0.5 小时的时间，将二偶氮颜料的水性浆料或泥浆制成粉末；以及 (b) 将由此获得的粉末在 50 至 150°C 的温度下保持 0.5 至 10 小时。
• Gas-phase kinetics ofN-substituted diacetamide
  作者：Nouria A. Al-Awadi、Fatima A. Al-Omran

  DOI：10.1002/kin.550260909

  日期：1994.9

  AbstractGas‐phase elimination reactions of number of N‐substituted diacetamides have been studied. The rates of N‐phenyl, 4‐methoxyphenyl, 4‐nitrophenyl, and benzyl diacetamide have been measured between 643–683, 642–693, 673–725, and 555–610 K, respectively. They undergo unimolecular first‐order elimination reactions, for which log A = 12.8, 12.9, 12.8, and 11.0 s−1 and Ea = 185.7, 191.4, 193.4, and 143.6 kJ mol−1, respectively. The reactivity of these compounds has been compared with the unsubstituted diacetamide at 600 K. The kinetic data reveals that each of the N‐aryldiacetamides is less reactive than the parent molecule. We attribute this observation to the resonance of the lone pair of electrons on the nitrogen with either the two carbonyl oxygen atoms or with the 6π electrons in the aromatic ring which will result in the stabilization of the N‐aryldiacetamides related to the parent molecules. © 1994 John Wiley & Sons, Inc.
• AYYANGAR, NAGARAJ, R.;SRINIVASAN, KUMAR, V., CAN. J. CHEM., 1984, 62, N 7, 1292-1296
  作者：AYYANGAR, NAGARAJ, R.、SRINIVASAN, KUMAR, V.

  DOI：——

  日期：——
• US4540815A
  申请人：——

  公开号：US4540815A

  公开（公告）日：1985-09-10