茜草酸 | 478-06-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 中文名称: 茜草酸
• 中文别名: 单-三苯代甲基1,4-二氨基丁烷乙酸盐
• 英文名称: 1,3-dihydroxy-9,10-anthraquinone-2-carboxylic acid
• 英文别名: munjistin；1,3-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid
• CAS: 478-06-8
• 化学式: C₁₅H₈O₆
• 分子量: 284.225
• InChiKey: PLDISGVCDWLKQC-UHFFFAOYSA-N

物化性质

• 熔点：
  228-230 °C
• 沸点：
  522.8±50.0 °C(Predicted)
• 密度：
  1.687±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  茜草酸 生成 二氧化碳 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Schunck; Roemer, Chemische Berichte, 1877, vol. 10, p. 175

  摘要：

  DOI：
• 作为产物：
  描述：

  1,3-二羟基-2-(羟基甲基)蒽醌 在 sodium hydroxide 、 silver(l) oxide 作用下， 生成 茜草酸
  参考文献：
  名称：

  Ayyangar; Venkataraman, Journal Of Scientific and Industrial Research, 1956, vol. 15 B, p. 359,361,362

  摘要：

  DOI：

文献信息

• Anthraquinones and naphthohydroquinones from Rubia cordifolia
  作者：Hideji Itokawa、Yafang Qiao、Koichi Takeya

  DOI：10.1016/0031-9422(89)80365-6

  日期：1989.1

  Abstract Four naphthohydroquinones and their glycosides, and 11 anthraquinones and their glycosides were isolated from the dried roots of Rubia cordifolia var. pratensis . Six of them, dihydromollugin, 2-carbomethoxy-3-(3′- hydroxy)isopentyl-1,4-naphthohydroquinone 4- O -β-glucoside, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone 3- O -β-glucoside, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone 3- O -(3′-

  摘要 从茜草干根中分离得到4 种萘氢醌及其苷类、11 种蒽醌类及其苷类。蒲公英。其中六种，二氢甲氧基-3-(3'-羟基)异戊基-1,4-萘氢醌4-O-β-葡萄糖苷，2-甲基-1,3,6-三羟基-9,10-蒽醌3-O-β-葡萄糖苷，2-甲基-1,3,6-三羟基-9,10-蒽醌3-O-(3'-O-乙酰基)-α-鼠李糖(1→2)-β-葡萄糖苷, 2-甲基-1,3,6-三羟基-9,10-蒽醌3-O-(3',6'-O-二乙酰)-α-鼠李糖基(1→2)-β-葡萄糖苷和2-甲基-1,3,6-三羟基-9,10-蒽醌3-O-(4',6'-O-二乙酰)-α-鼠李糖(1→2)-β-葡萄糖苷，首次被分离时间来自天然来源。这些结构是通过各种化学和光谱方法建立的。
• Rubber composition, an article of rubber reinforced with brass plated steel and a method of making such an article
  申请人：GENCORP INC.

  公开号：EP0234084A1

  公开（公告）日：1987-09-02

  The use of a small amount of polyhydroxy containing anthraquinone compound in a rubber ply or skim stock greatly improves the humid aged adhesion of the rubber stock to brass plated steel cords or fabric. This invention is particularly useful in tires with steel cords or belts. The following formula describes the anthraquinone compound: where two of the R's are hydroxyl radicals and the remaining R's are selected from the group consisting of-H,-OH,-CH3, -N02, -CH2OH and -COOH, at least four of the remaining R's being -H.

  在橡胶层或脱脂层中使用少量含多羟基的蒽醌化合物，可大大改善橡胶层与镀铜钢帘线或织物的潮湿老化粘附性。 本发明尤其适用于带有钢帘线或皮带的轮胎。 下式描述了蒽醌化合物：其中两个 R 是羟基，其余 R 选自-H、-OH、-CH3、-N02、-CH2OH 和-COOH 组成的组，其余 R 中至少有四个是-H。
• Matrix metalloproteinase inhibitors
  申请人：——

  公开号：US20020086877A1

  公开（公告）日：2002-07-04

  The present invention provides compounds that are effective in treating disorders caused by the enzymatic activity of matrix metalloproteinases. These disorders include, but are not limited to, rheumatoid arthritis, osteoarthritis, periodontal disease, aberrant angiogenesis, tumor invasion and metastasis, corneal ulceration, and in complications of diabetes. The present invention is also is useful for treating wounds.

  本发明提供的化合物可有效治疗由基质金属蛋白酶的酶活性引起的疾病。这些疾病包括但不限于类风湿性关节炎、骨关节炎、牙周病、异常血管生成、肿瘤侵袭和转移、角膜溃疡以及糖尿病并发症。本发明还可用于治疗伤口。
• Metasomatic coronas around hornblendite xenoliths in granulite facies marble, Ivrea zone, N Italy. II: Oxygen isotope patterns
  作者：R. Abart、R. Sperb

  DOI：10.1007/s004100100256

  日期：2001.7

  Up to 20-cm-wide metasomatic reaction bands formed coronas around hornblendite xenoliths in a marble matrix during high grade metamorphism in the Ivrea zone. The coronas are comprised of an innermost monomineralic clinopyroxene layer, a garnet-clinopyroxene layer and an outermost scapolite-clinopyroxene layer. The oxygen isotope composition of the original hornblendite core is 7%,, relative to V-SMOW and the oxygen isotope composition of the marble matrix is 19.7 parts per thousand. The oxygen isotope transition across the corona is represented by a diffusion front with a step discontinuity at the inner margin of the corona. The systematics of the inter-mineral fractionations indicates preservation of the oxygen isotope compositions from high temperatures and maintenance of grain-scale oxygen isotope equilibrium during corona formation. The oxygen isotope pattern is interpreted in terms of a moving boundary diffusion problem. The growing reaction band and the reactant hornblendite and marble represent a total of five media with different transport properties and moving separation surfaces. Bulk oxygen diffusion was at least three orders of magnitude faster then expected from volume diffusion, suggesting that transport was enhanced by relatively fast diffusion along grain boundaries. Oxygen diffusivities in the individual layers correlate with the oxygen volume diffusivities in the major constituent minerals of the respective layers, suggesting mineralogical control on bulk oxygen diffusion.
• Schunck; Roemer, Journal of the Chemical Society, 1878, vol. 33, p. 424
  作者：Schunck、Roemer

  DOI：——

  日期：——