3-(1H-benzo[d]imidazol-2-yl)-7-morpholino-2H-chromen-2-one | 162785-51-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3-(1H-benzo[d]imidazol-2-yl)-7-morpholino-2H-chromen-2-one
• 英文别名: 3-(1H-benzimidazol-2-yl)-7-morpholin-4-ylchromen-2-one
• CAS: 162785-51-5
• 化学式: C₂₀H₁₇N₃O₃
• 分子量: 347.373
• InChiKey: YJTNHHKLSFTSPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  67.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  7-溴-2-氧代-2H-色烯-3-羧酸乙酯 在 四丁基硫酸氢铵 、 potassium carbonate 、 sodium hydroxide 作用下， 以 乙醇 、 水 、 乙腈 为溶剂， 反应 14.0h， 生成 3-(1H-benzo[d]imidazol-2-yl)-7-morpholino-2H-chromen-2-one
  参考文献：
  名称：

  Synthesis of new conjugated coumarin–benzimidazole hybrids and their anticancer activity

  摘要：

  A series of novel coumarin-benzimidazole hybrids, 3-(1H-benzo[d]imidazol-2-yl)-7-(substituted amino)-2H-chromen-2-one derivatives of biological interest were synthesized. Six out of the newly synthesized compounds were screened for in vitro antitumor activity against preliminary 60 tumor cell lines panel assay. A significant inhibition for cancer cells was observed with compound 8 (more than 50% inhibition) compared with other compounds and active known drug 5-fluorouracil (in some cell lines) as positive control. Compound 8 displayed appreciable anticancer activities against leukemia, colon cancer and breast cancer cell lines. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.12.071

文献信息

• [EN] COMPOSITION CONTAINING SEMICONDUCTOR NANOPARTICLES, COLOR FILTER, AND IMAGE DISPLAY DEVICE<br/>[FR] COMPOSITION CONTENANT DES NANOPARTICULES SEMI-CONDUCTRICES, FILTRE COLORÉ ET DISPOSITIF D'AFFICHAGE D'IMAGE<br/>[JA] 半導体ナノ粒子含有組成物、カラーフィルタ、及び画像表示装置
  申请人：MITSUBISHI CHEM CORP

  公开号：WO2022044759A1

  公开（公告）日：2022-03-03

  励起光を効率よく波長変換し、十分な発光強度を示す波長変換層を形成することが可能な半導体ナノ粒子含有組成物を提供する。半導体ナノ粒子（Ａ）、リガンド（Ｂ）、及び蛍光色素（Ｃ）を含有する半導体ナノ粒子含有組成物であって、前記半導体ナノ粒子（Ａ）は、波長３００～７８０ｎｍの範囲における最大発光波長が５００～６７０ｎｍの範囲内にあり、前記リガンド（Ｂ）は、ヒドロキシ基を有することを特徴とする。
• Synthesis of new conjugated coumarin–benzimidazole hybrids and their anticancer activity
  作者：Kamaldeep Paul、Shweta Bindal、Vijay Luxami

  DOI：10.1016/j.bmcl.2012.12.071

  日期：2013.6

  A series of novel coumarin-benzimidazole hybrids, 3-(1H-benzo[d]imidazol-2-yl)-7-(substituted amino)-2H-chromen-2-one derivatives of biological interest were synthesized. Six out of the newly synthesized compounds were screened for in vitro antitumor activity against preliminary 60 tumor cell lines panel assay. A significant inhibition for cancer cells was observed with compound 8 (more than 50% inhibition) compared with other compounds and active known drug 5-fluorouracil (in some cell lines) as positive control. Compound 8 displayed appreciable anticancer activities against leukemia, colon cancer and breast cancer cell lines. (C) 2013 Elsevier Ltd. All rights reserved.