N-亚麻基肌氨酸 | 26408-39-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-亚麻基肌氨酸
• 中文别名: (Z,Z)-N-甲基-N-(9,12-十八碳二烯酰基)氨基乙酸
• 英文名称: Linoleoyl sarcosine
• 英文别名: 2-[methyl-[(9Z,12Z)-octadeca-9,12-dienoyl]amino]acetic acid
• CAS: 26408-39-9
• 化学式: C₂₁H₃₇NO₃
• 分子量: 351.5
• InChiKey: JWHARDIWYCXHAN-NQLNTKRDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  25
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Formulation for bispecific T-cell engagers (BiTEs)
  申请人：AMGEN INC.

  公开号：US11052128B2

  公开（公告）日：2021-07-06

  The present invention relates to stable pharmaceutical compositions which contain polypeptides having at least two antigen-binding domains and are especially suited for subcutaneous administration. The invention provides liquid compositions which minimize the formation of undesired polypeptide aggregates (dimers and/or multimers). The present invention further provides a method for minimizing the aggregation of polypeptides having antigen-binding domains in liquid compositions.

  本发明涉及稳定的药物组合物，其中含有至少两个抗原结合域的多肽，特别适合皮下注射。本发明提供的液体组合物能最大程度地减少不希望的多肽聚集体（二聚体和/或多聚体）的形成。本发明进一步提供了一种方法，可最大限度地减少液体组合物中具有抗原结合域的多肽的聚集。
• FORMULATION FOR BISPECIFIC T-CELL ENGAGERS (BITES)
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20150335706A1

  公开（公告）日：2015-11-26

  The present invention relates to stable pharmaceutical compositions which contain polypeptides having at least two antigen-binding domains and are especially suited for subcutaneous administration. The invention provides liquid compositions which minimize the formation of undesired polypeptide aggregates (dimers and/or multimers). The present invention further provides a method for minimizing the aggregation of polypeptides having antigen-binding domains in liquid compositions.
• US4532056A
  申请人：——

  公开号：US4532056A

  公开（公告）日：1985-07-30