N-十二烷基甲烷磺酰胺 | 79253-28-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 中文名称: N-十二烷基甲烷磺酰胺
• 英文名称: N-dodecylmethanesulfonamide
• CAS: 79253-28-4
• 化学式: C₁₃H₂₉NO₂S
• 分子量: 263.445
• InChiKey: IFRSZVJWYIYNAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  17
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-十二烷基甲烷磺酰胺 在 PPA 作用下， 反应 1.0h， 以74%的产率得到十二烷基伯胺
  参考文献：
  名称：

  Synthesis of 13-acylamino-huprines: different behavior of diastereomeric 13-methanesulfonamido-huprines on PPA-mediated hydrolysis

  摘要：

  Two diastereomeric pairs of rationally designed huprines additionally substituted at position 13 with a formamido or an acetamido group have been synthesized as potential high affinity acetylcholinesterase inhibitors. The synthetic sequence involves hydrolysis of two diastereomeric 13-methanesulfonamido-huprines, followed by acylation of the resulting diastereomeric amines. In the hydrolysis reaction, carried out with PPA under harsh conditions, significant amounts of cyclized or rearranged by-products were also formed, depending on the stereochemistry of the starting compound. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.04.054
• 作为产物：
  描述：

  N-(3,5-dimethoxybenzyl)-N-dodecylmethanesulfonamide 在 N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4]diazepine-2,12-diamine 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 72.0h， 以64%的产率得到N-十二烷基甲烷磺酰胺
  参考文献：
  名称：

  通过中性有机供体的光活化电子转移对 C?N 和 S?N 键进行无金属还原裂解

  摘要：

  光活化的中性有机超电子供体在室温下裂解衍生自二烷基胺的具有挑战性的芳烃磺酰胺。它还裂解 a) ArC  NR 和 b) ArN  C 键。该研究还强调了通过降低 LUMO 能量和稳定碎裂产物，连接到 (a) 中的 N 和连接到 (b) 中的 C 的基团对这些裂解反应的帮助。

  DOI：

  10.1002/anie.201306543

文献信息

• 4-(1-hydroxy-2-N-substituted sulfonamido)
  申请人：Allergan, Inc.

  公开号：US05081261A1

  公开（公告）日：1992-01-14

  Compounds of Formula 1, and of Formula 2, ##STR1## in which R.sub.1 is H or alkyl of 1 to 20 carbons, CO--R.sub.1.sup.* CO--O--R.sub.1.sup.* CO--NH--R.sub.1.sup.* or PO(OR.sub.1.sup.*).sub.2 or PO(OR.sub.1.sup.*)R.sub.1.sup.* where R.sub.1.sup.* independently is H, alkyl of 1 to 20 carbons, phenyl, or substituted phenyl; R.sub.2 is H, alkyl of 1 to 20 carbons, or R.sub.2 and Y jointly represent a heterocycle which incorporates the sulfonamide nitrogen in the ring as a heteroatom; R.sub.3 is H or alkyl of 1 to 20 carbons; X is H, R.sub.4, CO--R.sub.4, CO--O--R.sub.4, CO--NH--R.sub.4, CO--N--(R.sub.4).sub.2, PO(OR.sub.4).sub.2 or PO(OR.sub.4)R.sub.4, and R.sub.4 independently is H, phenyl, substituted phenyl, alkyl of 1 to 20 carbons or is alkyl of 1 to 20 carbons substituted with a hydroxyl, alkoxy, substituted amino, thioalkoxy, with a O--COR.sub.4.sup.* group or with a COR.sub.4.sup.* group where R.sub.4.sup.* is H, lower alkyl, OH, OR.sub.4.sup.**, NH.sub.2, NHR.sub.4.sup.** or N(R.sub.4.sup.**).sub.2 group where R.sub.4.sup.** independently is H or lower alkyl, with the proviso that when X is CO--O--R.sub.4 or is CO--NH--R.sub.4 then R.sub.4 is not hydrogen, and Y is H, phenyl or substituted phenyl, or alkyl of 1 to 20 carbons, or is alkyl of 1 to 20 carbons substituted with a hydroxyl, alkoxy, substituted amino, thioalkoxy, O--PO(OR.sub.5).sub.2, O--PO(OR.sub.5)R.sub.5, O--SO.sub.3 H, O--SO.sub.2 R.sub.5, O--COR.sub.5, or COR.sub.5 group where R.sub.5 is H, lower alkyl, OH, OR.sub.5.sup.*, NH.sub.2, NHR.sub.5.sup.* or N(R.sub.5.sup.*).sub.2 group where R.sub.5.sup.* is lower alkyl, or R.sub.2 and Y jointly represent a heterocycle which incorporates the sulfonamide nitrogen in the ring as a heteroatom, with the proviso that when Y is an alkyl substituted with O--PO(OR.sub.5).sub.2 or with O--PO(OR.sub. 5)R.sub.5 then R.sub.5 is not OH, are disclosed. The compounds possess anti-inflammatory activity.

  化合物的化学式1和化学式2如下所示：其中R.sub.1为H或含有1至20个碳原子的烷基，CO--R.sub.1.sup.*，CO--O--R.sub.1.sup.*，CO--NH--R.sub.1.sup.*或PO(OR.sub.1.sup.*).sub.2或PO(OR.sub.1.sup.*)R.sub.1.sup.*，其中R.sub.1.sup.*独立地为H，含有1至20个碳原子的烷基，苯基或取代苯基；R.sub.2为H，含有1至20个碳原子的烷基，或R.sub.2和Y共同代表一个杂环，其中该杂环将磺胺酰胺氮原子作为杂原子；R.sub.3为H或含有1至20个碳原子的烷基；X为H，R.sub.4，CO--R.sub.4，CO--O--R.sub.4，CO--NH--R.sub.4，CO--N--(R.sub.4).sub.2，PO(OR.sub.4).sub.2或PO(OR.sub.4)R.sub.4，其中R.sub.4独立地为H，苯基，取代苯基，含有1至20个碳原子的烷基或含有1至20个碳原子的烷基，其被羟基，烷氧基，取代氨基，硫代烷氧基，O--COR.sub.4.sup.*基或COR.sub.4.sup.*基取代，其中R.sub.4.sup.*为H，低碳烷基，OH，OR.sub.4.sup**，NH.sub.2，NHR.sub.4.sup**或N(R.sub.4.sup**).sub.2基，其中R.sub.4.sup.**独立地为H或低碳烷基，但当X为CO--O--R.sub.4或CO--NH--R.sub.4时，R.sub.4不为氢，Y为H，苯基或取代苯基，含有1至20个碳原子的烷基，或含有1至20个碳原子的烷基，其被羟基，烷氧基，取代氨基，硫代烷氧基，O--PO(OR.sub.5).sub.2，O--PO(OR.sub.5)R.sub.5，O--SO.sub.3 H，O--SO.sub.2 R.sub.5，O--COR.sub.5或COR.sub.5基取代，其中R.sub.5为H，低碳烷基，OH，OR.sub.5.sup*，NH.sub.2，NHR.sub.5.sup*或N(R.sub.5.sup*).sub.2基，其中R.sub.5.sup*为低碳烷基，或R.sub.2和Y共同代表一个杂环，其中该杂环将磺胺酰胺氮原子作为杂原子，但当Y为含有O--PO(OR.sub.5).sub.2或O--PO(OR.sub.5)R.sub.5取代的烷基时，R.sub.5不为OH。这些化合物具有抗炎活性。
• METHOD FOR PRODUCING TRANS-BIS(AMINOMETHYL)CYCLOHEXANE, METHOD FOR PRODUCING BIS(ISOCYANATOMETHYL)CYCLOHEXANE, BIS(ISOCYANATOMETHYL)CYCLOHEXANE, POLYISOCYANATE COMPOSITION, AND POLYURETHANE RESIN
  申请人：MITSUI CHEMICALS, INC.

  公开号：US20160207875A1

  公开（公告）日：2016-07-21

  A method for producing trans-bis(aminomethyl)cyclohexane includes a trans-isomerization step in which cis-dicyanocyclohexane is isomerized into trans-dicyanocyclohexane by heating dicyanocyclohexane containing cis-dicyanocyclohexane in the presence of a tar component produced by distillation of dicyanocyclohexane; and an aminomethylation step in which trans-dicyanocyclohexane produced by the trans-isomerization step is allowed to contact with hydrogen to produce trans-bis(aminomethyl)cyclohexane.

  生产反式-双(氨甲基)环己烷的方法包括以下步骤：在一个反式异构化步骤中，通过加热含有顺-二氰基环己烷的二氰基环己烷，在二氰基环己烷的蒸馏产生的焦油组分的存在下，将顺-二氰基环己烷异构化为反-二氰基环己烷；以及在一个氨甲基化步骤中，通过让通过反式异构化步骤产生的反-二氰基环己烷与氢接触来产生反式-双(氨甲基)环己烷。
• TRANSITION METAL COMPLEX AND PROCESS FOR PRODUCING CONJUGATED AROMATIC COMPOUND USING THE TRANSITION METAL COMPLEX
  申请人：Asaumi Taku

  公开号：US20110046336A1

  公开（公告）日：2011-02-24

  A transition metal complex obtained by contacting a bipyridine compound represented by the formula (1): wherein R 1 , R 2 and R 3 represent a C1-C10 alkyl group which may be substituted, etc., and R 4 and R 5 represent a hydrogen atom etc., with a compound of a transition metal belonging to Group 9, 10 or 11, and a process for producing a conjugated aromatic compound comprising reacting an aromatic compound (A) wherein one or two leaving groups are bonded to an aromatic ring with an aromatic compound (A) having the same structure as that of the above-mentioned aromatic compound (A) or an aromatic compound (B) being structurally different from the above-mentioned aromatic compound (A) and having one or two leaving groups bonded to an aromatic ring, in the presence of said transition metal complex.

  通过将式（1）所表示的联吡啶化合物与属于9、10或11族的过渡金属化合物接触而获得的过渡金属配合物，其中R1、R2和R3代表C1-C10烷基，可以被取代等，而R4和R5代表氢原子等。制备共轭芳香化合物的方法包括，在所述过渡金属配合物的存在下，将一个芳香化合物（A），其中一个或两个离去基团与芳香环相键合，与具有与上述芳香化合物（A）相同结构的芳香化合物（A）或在结构上不同于上述芳香化合物（A）并且具有一个或两个离去基团与芳香环相键合的芳香化合物（B）反应。
• METHOD FOR PRODUCING 1,5-PENTAMETHYLENEDIAMINE, 1,5-PENTAMETHYLENEDIAMINE, 1,5-PENTAMETHYLENE DIISOCYANATE, METHOD FOR PRODUCING 1,5-PENTAMETHYLENE DIISOCYANATE, POLYISOCYANATE COMPOSITION, AND POLYURETHANE RESIN
  申请人：Hidesaki Tomonori

  公开号：US20130079486A1

  公开（公告）日：2013-03-28

  In a method for producing 1,5-pentamethylenediamine, a lysine decarboxylase-expressing microorganism that is subjected to a treatment is used.

  在生产1,5-戊二胺的方法中，使用经过处理的赖氨酸脱羧酶表达微生物。
• METHOD FOR PRODUCING 1,5-PENTAMETHYLENEDIAMINE, MUTANT LYSINE DECARBOXYLASE, METHOD FOR PRODUCING 1,5-PENTAMETHYLENE DIISOCYANATE AND METHOD FOR PRODUCING POLYISOCYANATE COMPOSITION
  申请人：MITSUI CHEMICALS, INC.

  公开号：US20150132808A1

  公开（公告）日：2015-05-14

  A mutant lysine decarboxylase is produced by replacing at least one of the amino-acids in the amino acid sequence shown in sequence ID No. 4 of the sequence listing with another amino-acid.

  通过将序列清单中序列ID编号为4的氨基酸序列中的至少一个氨基酸替换为另一个氨基酸，产生了一种突变的赖氨酸脱羧酶。