(S)-3-(4-aminobenzyl)piperazine-2,5-dione | 1628630-20-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-3-(4-aminobenzyl)piperazine-2,5-dione
• 英文别名: (3S)-3-[(4-aminophenyl)methyl]piperazine-2,5-dione
• CAS: 1628630-20-5
• 化学式: C₁₁H₁₃N₃O₂
• 分子量: 219.243
• InChiKey: YSTFLJNSVDIMQK-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  84.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  BOC-L-4-硝基苯丙氨酸 在 20% palladium hydroxide-activated charcoal 、 氢气 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 1.67h， 生成 (S)-3-(4-aminobenzyl)piperazine-2,5-dione
  参考文献：
  名称：

  带有苄基部分的二酮哌嗪的合成和构象表征

  摘要：

  合成带有苄基部分和不同对位取代基的二酮哌嗪并通过 1 H NMR 光谱分析。发现所有这些二酮哌嗪都采用折叠的构形...

  DOI：

  10.1246/cl.131001

文献信息

• Piperazine-2,5-diones as TGF-beta inhibitors
  申请人：SOUTHERN RESEARCH INSTITUTE

  公开号：US11505531B2

  公开（公告）日：2022-11-22

  The present disclosure is concerned with piperazine-2,5-diones that are capable of inhibiting TGF-β and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开涉及能够抑制 TGF-β 的哌嗪-2,5-二酮和治疗癌症（例如多发性骨髓瘤和血液恶性肿瘤）的方法，以及使用这些化合物治疗纤维化病症的方法。本摘要旨在作为在特定技术领域进行搜索的扫描工具，并非对本发明的限制。
• PIPERAZINE-2,5-DIONES AS TGF-BETA INHIBITORS
  申请人：Southern Research Institute

  公开号：US20210323933A1

  公开（公告）日：2021-10-21

  The present disclosure is concerned with piperazine-2,5-diones that are capable of inhibiting TGF-β and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• [EN] PIPERAZINE-2,5-DIONES AS TGF-BETA INHIBITORS<br/>[FR] PIPÉRAZINE-2,5-DIONES EN TANT QU'INHIBITEURS DE TGF-BÊTA
  申请人：SOUTHERN RES INST

  公开号：WO2020033317A1

  公开（公告）日：2020-02-13

  The present disclosure is concerned with piperazine-2,5-diones that are capable of inhibiting TGF-β and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• Synthesis and Conformational Characterization of Diketopiperazines Bearing a Benzyl Moiety
  作者：Michiyasu Nakao、Yuriko Toriuchi、Shintaro Fukayama、Shigeki Sano

  DOI：10.1246/cl.131001

  日期：2014.3.5

  Diketopiperazines bearing a benzyl moiety with different para-substituents were synthesized and analyzed by 1H NMR spectroscopy. All of these diketopiperazines were found to adopt a folded conforma...

  合成带有苄基部分和不同对位取代基的二酮哌嗪并通过 1 H NMR 光谱分析。发现所有这些二酮哌嗪都采用折叠的构形...