N-十六烷基十八烷胺 | 45310-14-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-十六烷基十八烷胺
• 英文名称: N-hexadecyloctadecan-1-amine
• 英文别名: Palmitylstearylamine
• CAS: 45310-14-3
• 化学式: C₃₄H₇₁N
• 分子量: 493.944
• InChiKey: YPMXMXFOJOBIKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16.4
• 重原子数：
  35
• 可旋转键数：
  32
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-十六烷基十八烷胺 在 三乙胺 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 13.17h， 生成
  参考文献：
  名称：

  具有不同烃尾的血清相容性精胺基阳离子脂质介导高转染效率

  摘要：

  与市售转染剂 Lipofectamine3000 相比，具有不同疏水链的 L 形精胺基阳离子脂质在无血清和 10-40% 血清条件下表现出出色的转染效率。

  DOI：

  10.1002/cbic.202100672
• 作为产物：
  描述：

  十八胺 在 potassium carbonate 、 三乙胺 、 2-巯基乙醇 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 14.0h， 生成 N-十六烷基十八烷胺
  参考文献：
  名称：

  具有不同烃尾的血清相容性精胺基阳离子脂质介导高转染效率

  摘要：

  与市售转染剂 Lipofectamine3000 相比，具有不同疏水链的 L 形精胺基阳离子脂质在无血清和 10-40% 血清条件下表现出出色的转染效率。

  DOI：

  10.1002/cbic.202100672

文献信息

• Polyether-modified polymers as leather auxiliaries
  申请人：Reiners Juergen

  公开号：US20050058619A1

  公开（公告）日：2005-03-17

  (Co)polymers which contain a) structural units of the general formula I in which W represents a trivalent radical from the group in which * indicates the orientation for the incorporation of the radical W into the formula I, and Z represents the radicals —OH, —O − M + or —N—R 1 R 2 , in which R 1 and R 2 , independently of one another, represent hydrogen, optionally substituted alkyl radicals, alkenyl radicals, aralkyl radicals or cycloalkyl radicals, which may be interrupted by 0 atoms, N atoms, Si atoms or amido, carbonate, urethane, urea, allophanate, biuret or isocyanurate groups or mixtures thereof, and M + represents H + or an alkali metal ion, an NH 4 ion or a primary, secondary, tertiary or quaternary aliphatic ammonium radical which preferably carries a C 1 -C 22 -alkyl or C 1 -C 22 -hydroxyalkyl group, b) at least 10 mol %, based on the units of the formula I, of structural units of the general formula Ia in which R 3 represents a hydrocarbon radical having C 1 -C 60 -atoms, preferably a saturated C 1 -C 60 -alkyl radical, in particular C 12 -C 30 -alkyl radical, and R 4 represents hydrogen or has the same meaning as R 3 , and e) polyether units having an average molecular weight of 200 - 6000 g/mol.

  聚合物包含a) 通式I的结构单元，其中W代表来自该组的三价基团，其中*表示将基团W合并到通式I中的取向，Z代表基团—OH，—O−M+或—N—R1R2，其中R1和R2独立地表示氢，可选择地取代的烷基基团，烯基基团，芳基烷基基团或环烷基基团，可以由0个原子，N原子，Si原子或酰胺，碳酸酯，脲，脲，异氰酸酯，双脲基或异氰酸酯基团或它们的混合物中断，并且M+表示H+或碱金属离子，NH4离子或一种一级，二级，三级或季铵基团，最好携带C1-C22-烷基或C1-C22-羟基烷基基团，b)至少占通式I单位的10摩尔％的通式Ia的结构单元，其中R3代表具有C1-C60原子的碳氢基团，优选为饱和的C1-C60烷基基团，特别是C12-C30烷基基团，和R4代表氢或具有与R3相同的含义，以及e) 平均分子量为200-6000g/mol的聚醚单元。
• Scaling the effect of hydrophobic chain length on gene transfer properties of di-alkyl, di-hydroxy ethylammonium chloride based cationic amphiphiles
  作者：Ankita A. Hiwale、Chandrashekhar Voshavar、Priya Dharmalingam、Ashish Dhayani、Rajesh Mukthavaram、Rasajna Nadella、Omprakash Sunnapu、Sivaraman Gandhi、V. G. M. Naidu、Arabinda Chaudhuri、Srujan Marepally、Praveen Kumar Vemula

  DOI：10.1039/c7ra02271a

  日期：——

  availability of efficient transfection vectors. Cationic lipids are the most widely studied non-viral vectors. The molecular architecture of the cationic lipid determines its transfection efficiency. Variations in alkyl chain lengths of lipids influence self-assembly and liposomal fusion with the cell membrane. These factors determine the transfection ability of the lipid. Thus, to probe the effect

  基因治疗的成功关键取决于有效转染载体的可用性。阳离子脂质是研究最广泛的非病毒载体。阳离子脂质的分子结构决定了其转染效率。脂质的烷基链长度变化会影响自组装和脂质体与细胞膜的融合。这些因素决定了脂质的转染能力。因此，为了探究疏水链中不对称性对转染效率的影响，我们通过系统性地将连接到季氮中心的两个烷基链中的一个烷基从C18变为C10，并保留另一个烷基C18链，设计并合成了一系列阳离子脂质恒定（Lip1818-Lip1810）。在多种培养的哺乳动物细胞（CHO，B16F10和HeLa）中的转染研究表明，具有C18：C14和C18：C12烷基链的脂质（Lip1814和Lip1812）在脂质与pDNA电荷比为2：1和4：1时显示出比同等产品高20–30％的转染效率。低温透射电子图像显示脂质脂质体的单层囊泡结构。涉及小角X射线散射（SAXS）的机理研究表明，疏水区的不对称性对脂质体与质膜模型融合的影响很
• Coated, Oriented polymer film laminate
  申请人：MOBIL OIL CORPORATION

  公开号：EP0237213A2

  公开（公告）日：1987-09-16

  A coated, oriented polymer film laminate is provided which comprises: a) an oriented core layer having an upper face and a lower face, the core layer being fabricated froma polypropylene homopolymer; b) an oriented, heat sealable layer applied to the lower face, and optionally, to the upper face, of core layer (a), the heat sealable layer being fabricated from a heat sealable copolymer or blend of copolymers, heat sealable blend of homopolymers and heat sealable blend of at least one copolymer and at least one homopolymer; and c) a coating layer applied to the upper face of core layer (a), or, where heat sealable layer (b) has been applied thereto, to the exposed surface of layer (b), the coating layer being derived from an interpolymer which is obtained from the interpolymerization of from about 0 to 15 parts of weight of an alpha-beta monoethylenically unsaturated carboxylic acid selected from acrylic acid, methacrylic acid and mixtures thereof with from about 85 to about 100 parts by weight of neutral monomer esters.

  提供了一种涂层拉伸聚合物薄膜层压板，它包括 a) 具有上表面和下表面的拉伸芯层，芯层由聚丙烯均聚物制成； b) 在芯层(a)的下端面，也可选择在上端面，涂上一层可热封的定向层，热封层由可热封的共聚物或共聚物混合物、可热封的均聚物混合物以及至少一种共聚物和至少一种均聚物的可热封混合物制成；以及 c) 涂料层：涂在芯层（a）的上表面，或在涂有可热封层（b）的情况下，涂在芯层（b）的外露表面，涂料层由互聚物制成，该互聚物由α-β单乙烯不饱和羧酸（选自丙烯酸、甲基丙烯酸及其混合物）与中性单体酯（按重量计约 85 至约 100 份）互聚而得，互聚物的重量约为 0 至 15 份。
• Pigmented, heat-sealable coating composition for application to oriented polyolefin films
  申请人：MOBIL OIL CORPORATION

  公开号：EP0221690A2

  公开（公告）日：1987-05-13

  A pigmented, heat-sealable coating composition for application to a primer-coated, oriented mono-layer or multi-layer polyolefin film is provided which comprises a blend of (a) a binding and oxygen barrier effective amount of a heat-sealable polyvinyl­idene chloride homopolymer and/or polyvinylidene chloride copolymer containing at least 50 weight percent copolymerized vinylidene chloride, (b) an amount of wax sufficient to result in a significant reduction in the coefficient of friction of a film to which the coating composition is applied and (c) an amount of pigment sufficient to result in a significant reduction in the light transmission property of a film to which the coating composition is applied. Oriented polyolefin films coated with the foregoing compositions possess excellent seal strength and hot tack properties, good blocking resistance, low coefficient of friction, low oxygen transmission rate and low light transmission.

  本发明提供了一种涂有颜料、可热封的涂层组合物，用于涂有底漆的定向单层或多层聚烯烃薄膜，该组合物包括以下物质的混合物：(a) 有效结合量和阻氧量的可热封聚偏二氯乙烯均聚物和/或聚偏二氯乙烯共聚物，其中共聚偏二氯乙烯的重量百分比至少为 50%、(b) 蜡的用量足以显著降低涂有涂层组合物的薄膜的摩擦系数，以及 (c) 颜料的用量足以显著降低涂有涂层组合物的薄膜的透光性。 使用上述组合物涂覆的定向聚烯烃薄膜具有优异的密封强度和热粘性能、良好的抗阻塞性、低摩擦系数、低透氧率和低透光率。
• Articles and methods for treating fabrics
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0267657A2

  公开（公告）日：1988-05-18

  Disclosed are dryer-added fabric conditioning articles and methods utilizing alkyl amine-anionic surfactant ion-pair complexes as fabric conditioning agents. Optionally, these compositions can contain polymeric soil realease agents and the fabric softeners. In the method aspect of the invention, damp fabrics are commingled with the conditioner active and optional components in an automatic laundry dryer and are provided with a soft, antistatic finish concurrently with the drying operation. The fabric conditioning agents herein are preferably employed in combination with a dispensing means adapted for use in an automatic dryer.

  本发明公开了利用烷基胺-阴离子表面活性剂离子对复合物作为织物护理剂的烘干机添加织物护理用品和方法。可选地，这些组合物还可包含聚合物土壤改良剂和织物柔软剂。在本发明的方法中，潮湿的织物与调节剂活性成分和可选成分在自动洗衣干燥机中混合，并在干燥的同时获得柔软的抗静电效果。本发明中的织物调理剂最好与适用于自动烘干机的分配装置结合使用。