PD151746

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: PD151746
• 英文别名: 3-(5-Fluoro-3-indolyl)-2-mercapto-(Z)-2-propenoic Acid；(Z)-3-(5-fluoro-1H-indol-3-yl)-2-sulfanylprop-2-enoic acid
• 化学式: C₁₁H₈FNO₂S
• 分子量: 237.254
• InChiKey: HWMQHECFXSVZGN-KMKOMSMNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.1
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• COMPOSITIONS AND METHODS FOR PRESERVING PLATELET FUNCTION
  申请人：BIOVEC TRANSFUSION, LLC

  公开号：US20150056604A1

  公开（公告）日：2015-02-26

  Compositions and methods for maintaining platelet functionality and extending the shelf-life of platelets are described. Platelet preservation compositions include a photosensitizer and a plurality of platelet preservation agents. A method for preserving platelets and extending their shelf-life includes irradiating a platelet mixture containing a photosensitizer under conditions sufficient to activate the photosensitizer and inactivate microbes in the platelet mixture to form a microbe-depleted platelet preparation. A plurality of platelet preservation agents are added to the microbe-depleted platelet preparation for extending the platelet shelf-life. Prior to transfusion, the photosensitizer and platelet preservation agents can be removed by diafiltration and/or the use of compound adsorption devices.

  本文描述了维持血小板功能和延长血小板货架寿命的组合物和方法。血小板保存组合物包括光敏剂和多种血小板保存剂。一种保存血小板并延长其货架寿命的方法包括在足以激活光敏剂并灭活血小板混合物中的微生物的条件下，照射含有光敏剂的血小板混合物，以形成去除微生物的血小板制备物。在延长血小板货架寿命之前，向去除微生物的血小板制备物中添加多种血小板保存剂。在输血之前，可以通过透析和/或使用化合物吸附装置去除光敏剂和血小板保存剂。
• Methods and compositions for restoring homeostatic capacity of a subject
  申请人：Palo Alto Investors

  公开号：US10835134B2

  公开（公告）日：2020-11-17

  Methods of restoring homeostatic capacity of a subject are provided. Aspects of the invention further include compositions, systems and devices for practicing the methods. The methods and compositions described herein find use in a variety of applications. Aspects of certain embodiments of the methods include modulating a subject's autonomic nervous system in a manner sufficient to restore the homeostatic capacity of the subject. Aspects of other embodiments of the invention include administering to the subject an amount of an apoptosis modulator effective to at least partially restore homeostatic function of the neuroendocrine system of the subject.

  本发明提供了恢复受试者体内平衡能力的方法。本发明的各个方面还包括用于实施这些方法的组合物、系统和设备。本文所述的方法和组合物可用于多种应用。本发明方法的某些实施方案包括以足以恢复受试者平衡能力的方式调节受试者的自律神经系统。本发明其他实施方案的方面包括向受试者施用一定量的细胞凋亡调节剂，其有效量至少可部分恢复受试者神经内分泌系统的平衡功能。
• RADIOIMAGING MOIETIES COUPLED TO PEPTIDASE-BINDING MOIETIES FOR IMAGING TISSUES AND ORGANS THAT EXPRESS PEPTIDASES
  申请人：Molecular Insight Pharmaceuticals, Inc.

  公开号：EP2061518A2

  公开（公告）日：2009-05-27
• TARGETS FOR TREATMENT OF CHLAMYDIAL INFECTIONS
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP2352840A2

  公开（公告）日：2011-08-10
• RADIOIMAGING MOIETIES COUPLED TO PEPTIDEASE-BINDING MOIETIES FOR IMAGING TISSUES AND ORGANS THAT EXPRESS PEPTIDASES
  申请人：Babich J. W.

  公开号：US20080213172A1

  公开（公告）日：2008-09-04

  Conjugates, methods and kits are described for imaging tissues and organs that express one or more peptidases. In a preferred embodiment of the invention, a series of di-(2-pyridylmethyl)amine (D) ligands, which can bind M(CO) 3 + [M=Tc or Re], were coupled to lisinopril (L). Aliphatic tethers with varying number of methylene groups (3, 4, 5, and 7; D(C 4 )L, D(C 5 )L, D(C 6 )L, and D(C 8 )L, respectively) were utilized, with in vitro inhibitory activity increasing with increasing number of methylene groups. The D(C 8 )L conjugate was observed to be significantly more potent than D(C 4 )L. In vivo specificity for ACE was studied in both tissue distribution and gamma imaging studies, demonstrating localization in tissues with high ACE content. Localization was blocked by pretreatment with lisinopril.