N-<3-(o-azidophenyl)propyl>phthalimide | 146954-32-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-<3-(o-azidophenyl)propyl>phthalimide
• 英文别名: 2-[3-(2-Azidophenyl)propyl]isoindole-1,3-dione
• CAS: 146954-32-7
• 化学式: C₁₇H₁₄N₄O₂
• 分子量: 306.324
• InChiKey: OVFAVZOITIVEQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  51.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-<3-(o-azidophenyl)propyl>phthalimide 在 magnesium sulfate 、 一水合肼 作用下， 以 四氢呋喃 、 乙醚 、 乙醇 为溶剂， 反应 24.0h， 生成 [1-(2-Azido-5-methyl-phenyl)-meth-(E)-ylidene]-[3-(2-azido-phenyl)-propyl]-amine
  参考文献：
  名称：

  Synthetic applications of bis(iminophosphoranes). One-pot preparation of rigid bicyclic guanidines

  摘要：

  A one-pot synthesis of [6 + 6], [6 + 7], and [6 + 8] bicyclic guanidines based on a new method of dihydropyrimido annelation, which involves reaction of bis(iminophosphoranes) with aryl isocyanates or isothiocyanates is described. The method is also applicable for the preparation of chiral bicyclic guanidines.

  DOI：

  10.1021/jo00059a015
• 作为产物：
  描述：

  3-(2-氨基苯基)-1-丙醇 在 盐酸 、 sodium azide 、 三苯基膦 、 sodium nitrite 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 反应 28.5h， 生成 N-<3-(o-azidophenyl)propyl>phthalimide
  参考文献：
  名称：

  Synthetic applications of bis(iminophosphoranes). One-pot preparation of rigid bicyclic guanidines

  摘要：

  A one-pot synthesis of [6 + 6], [6 + 7], and [6 + 8] bicyclic guanidines based on a new method of dihydropyrimido annelation, which involves reaction of bis(iminophosphoranes) with aryl isocyanates or isothiocyanates is described. The method is also applicable for the preparation of chiral bicyclic guanidines.

  DOI：

  10.1021/jo00059a015

文献信息

• Aminocarboxylic acid derivatives
  申请人：Sanraku Incorporated

  公开号：EP0091594A1

  公开（公告）日：1983-10-19

  An aminocarboxylic acid derivative represented by the formula wherein R, and R2, independently from each other, represent a hydrogen atom or an alkyl group which may have a substituent, and Y represents -NH- or -S-, provided that when Y represents -NH-, at least one of R, and R2 represents an alkyl group which may have a substituent. This compound has excellent inhibitory activity on dipeptidase in animals, and is useful for administration in combination with carbapenem antibiotics.

  一种由式表示的氨基甲酸酯衍生物 其中 R 和 R2 各自代表氢原子或可带有取代基的烷基，Y 代表-NH-或-S-，但当 Y 代表-NH-时，R 和 R2 中至少有一个代表可带有取代基的烷基。该化合物对动物体内的二肽酶具有极佳的抑制活性，可与碳青霉烯类抗生素联合使用。
• Synthetic applications of bis(iminophosphoranes). One-pot preparation of rigid bicyclic guanidines
  作者：Pedro Molina、Mateo Alajarin、Angel Vidal

  DOI：10.1021/jo00059a015

  日期：1993.3

  A one-pot synthesis of [6 + 6], [6 + 7], and [6 + 8] bicyclic guanidines based on a new method of dihydropyrimido annelation, which involves reaction of bis(iminophosphoranes) with aryl isocyanates or isothiocyanates is described. The method is also applicable for the preparation of chiral bicyclic guanidines.