[(Z)-(3-hydroxy-1-methyl-6-oxo-2,3-dihydroindol-5-ylidene)amino]urea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: [(Z)-(3-hydroxy-1-methyl-6-oxo-2,3-dihydroindol-5-ylidene)amino]urea
• 化学式: C₁₀H₁₂N₄O₃
• 分子量: 236.23
• InChiKey: XSXCZNVKFKNLPR-SDQBBNPISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  108
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• TERPENE COUPLING CONJUGATE
  申请人：LABORATOIRES ERIGER

  公开号：US20210361771A1

  公开（公告）日：2021-11-25

  The subject matter of the present invention relates to the use of an optionally branched linear terpene having at most one C═C unsaturation for the production of conjugates provided with self-assembly properties, as well as a self-assembly agent of formula (I): X(-Spacer-Y-Terpene) p (I) in which: “Terpene” is linear, optionally branched, having at most one C═C unsaturation; “Y” is a bond or a molecular fragment with a biodegradable bond; “Spacer” is a bond or a fragment comprising at least one carbon atom; “X” is a molecular fragment comprising at least one biodegradable bond; “p” ranges between 0.1 and 4; and the “-Spacer-Y-” group optionally can be a bond, as well as the conjugate resulting from the combination of the self-assembly agent of formula (I) with an active molecule MA.

  本发明的主题涉及使用最多具有一个C═C不饱和度的线性可选择分支的萜烯，用于具有自组装特性的共轭物的生产，以及具有以下式(I)的自组装剂： X(-Spacer-Y-Terpene) p (I) 其中： “萜烯”是线性的，可选择分支的，最多具有一个C═C不饱和度； “Y”是一个具有可生物降解键的键或分子片段； “Spacer”是一个包含至少一个碳原子的键或片段； “X”是一个包含至少一个可生物降解键的分子片段； “p”范围在0.1至4之间；以及 “-Spacer-Y-”基团可以选择是一个键， 以及由式(I)的自组装剂与活性分子MA的组合产生的共轭物。
• Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients
  申请人：Rogers D. Robin

  公开号：US20070093462A1

  公开（公告）日：2007-04-26

  Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.

  揭示了离子液体及制备活性药物、生物、营养和能量成分的离子液体组合物的方法。还揭示了利用本文描述的组合物的方法，以克服多型性、克服溶解度和输送问题、控制释放速率、增加功能性、增强功效（协同作用）以及改善易用性和制造工艺。
• Bicyclic compound
  申请人：Miyoshi Shiro

  公开号：US20060069098A1

  公开（公告）日：2006-03-30

  A novel compound represented by the following formula (1) or a salt thereof: wherein symbol “A” represents a saturated heterocyclic group, a 5-membered heteroaromatic group having two heteroatoms in the ring, a group represented by the formula A1 (R 2 , R 3 , and R 4 represent hydrogen atom, hydroxyl group, etc.), etc., B represents a group represented by the formula B1 (R 11 represents hydrogen atom, hydroxyl group, etc.), etc., R 1 represents an alkyl group, and symbol “n” represents an integer of 2 to 6, which has a parathyroid hormone depressing action and showing low toxicity, and a medicament containing the compound or salt thereof as an active ingredient.

  以下公式（1）所代表的一种新化合物或其盐：其中符号“A”代表饱和杂环基，一个含有两个杂原子的5元杂芳基，一个由公式A1（R2、R3和R4代表氢原子、羟基等）所代表的基团，等等，B代表由公式B1（R11代表氢原子、羟基等）所代表的基团，等等，R1代表烷基，符号“n”代表一个整数，范围为2至6，具有降钙素抑制作用和低毒性，并且含有该化合物或其盐作为活性成分的药物。
• Wound Dressings, Methods of Using the Same and Methods of Forming the Same
  申请人：Stasko Nathan

  公开号：US20120136323A1

  公开（公告）日：2012-05-31

  Provided according to some embodiments of the invention are wound dressings that include a polymer matrix and nitric oxide-releasing polysiloxane macromolecules within and/or on the polymer matrix. Also provided are wound dressing kits and methods of using and forming such wound dressings.

  根据本发明的某些实施例，提供了包括聚合物基质和硅氧烷聚合物中释放一氧化氮的大分子的敷料。还提供了创伤敷料套件和使用和形成这种创伤敷料的方法。
• Water-dispersible patch containing an active agent for dermal delivery
  申请人：McEntire Edward Enns

  公开号：US20070259029A1

  公开（公告）日：2007-11-08

  A dermal patch having comprising at least two layers wherein at least one layer is a polymer matrix system having an active agent admixed therein. At least one of the layers includes a water-dispersible or water-dissipatable polymer. The dermal patch has an elongation factor of at least 50%.

  一种皮肤贴片，包括至少两层，其中至少一层是聚合物基质系统，其中混合了活性剂。至少一层包括可水分散或可水分散的聚合物。该皮肤贴片的伸长系数至少为50％。