Senecionan-11,16-dione, 13,19-didehydro-12-hydroxy-

• 分子结构分类: 有机化合物 - 生物碱及其衍生物
• 英文名称: Senecionan-11,16-dione, 13,19-didehydro-12-hydroxy-
• 英文别名: (4E)-4-ethylidene-7-hydroxy-7-methyl-6-methylidene-2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadec-11-ene-3,8-dione
• 化学式: C₁₈H₂₃NO₅
• 分子量: 333.4
• InChiKey: FCEVNJIUIMLVML-UUILKARUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  24
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• METHODS AND COMPOSITIONS FOR TREATING INFECTION
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US20150238473A1

  公开（公告）日：2015-08-27

  Provided herein are compositions and methods for treating or preventing infection.

  本文提供了用于治疗或预防感染的组合物和方法。
• Croos-B Structure Binding Compounds
  申请人：Gebbink Martijn Frans Ben Gerard

  公开号：US20080267948A1

  公开（公告）日：2008-10-30

  The invention relates to the field of biochemistry, biophysical chemistry, molecular biology, structural biology and medicine. More in particular, the invention relates to cross-β structure conformation. Even more particular, the invention relates to compounds capable of binding to a compound with cross-β structure conformation, i.e. cross-β structure binding compounds and uses thereof.

  本发明涉及生物化学、生物物理化学、分子生物学、结构生物学和医学领域。更具体地说，本发明涉及交叉β结构构象。更具体地说，本发明涉及能够结合具有交叉β结构构象的化合物的化合物，即交叉β结构结合化合物及其用途。
• METHOD OF PROLIFERATING HUMAN HEPATOCYTES AND METHOD OF OBTAINING HUMAN HEPATOCYTES
  申请人：Japan Science and Technology Agency

  公开号：EP1496110A1

  公开（公告）日：2005-01-12

  Transplanting human hepatocytes into a liver of an immunodeficient hepatopathy mouse, and then feeding the mouse transplanted with the human hepatocytes under such a condition as being protected from the attack by human complement produced by the human hepatocytes thereby proliferating the transplanted human hepatocytes in the mouse liver. Further, Obtaining human hepatocytes in large scale by repeating the above steps using the proliferated human hepatocytes.

  将人肝细胞移植到免疫缺陷性肝炎小鼠的肝脏中，然后在保护小鼠免受人肝细胞产生的人补体攻击的条件下喂养移植了人肝细胞的小鼠，从而使移植的人肝细胞在小鼠肝脏中增殖。进一步，使用增殖的人类肝细胞重复上述步骤，大规模获得人类肝细胞。
• METHOD OF TREATING MOUSE CARRYING HUMAN HEPATOCYTES
  申请人：Hiroshima Industrial Promotion Organization

  公开号：EP1915904A1

  公开（公告）日：2008-04-30

  Human adult hepatocytes are transplanted into an immunodeficient hepatopathy mouse and then human growth hormone is administered to the mouse to thereby elevate twice or more the replacement ratio by the human adult hepatocytes having been transplanted. Further, human growth hormone is administered to an immunodeficient hepatopathy mouse carrying human young hepatocytes transplanted thereinto so as to improve fatty liver of the mouse in which about 70% or more of the hepatocytes have been replaced by the human hepatocytes.

  将人类成人肝细胞移植到免疫缺陷肝病小鼠体内，然后给小鼠注射人类生长激素，从而将移植的人类成人肝细胞的替代率提高一倍或更多。此外，给移植了人类幼年肝细胞的免疫缺陷肝病小鼠注射人类生长激素，以改善小鼠的脂肪肝，其中约 70% 或更多的肝细胞已被人类肝细胞替代。
• Cross-ß structure binding compounds
  申请人：Crossbeta Biosciences B.V.

  公开号：EP2386861A2

  公开（公告）日：2011-11-16

  The invention relates to the field of biochemistry, biophysical chemistry, molecular biology, structural biology and medicine. More in particular, the invention relates to cross-β structure conformation. Even more particular, the invention relates to compounds capable of binding to a compound with cross-β structure conformation, i.e. cross-β structure binding compounds and uses thereof.

  本发明涉及生物化学、生物物理化学、分子生物学、结构生物学和医学领域。更具体地说，本发明涉及交叉β结构构象。更具体地说，本发明涉及能够与具有交叉β结构构象的化合物结合的化合物，即交叉β结构结合化合物及其用途。

表征谱图