2,2-Dimethyl-3-(2-methyl-propenyl)-cyclopropanecarboxylic acid 2-methyl-4-oxo-3-((E)-penta-2,4-dienyl)-cyclopent-2-enyl ester | 56586-14-2

• 物质功能分类: 化学农药原药 - 杀虫剂 - 拟除虫菊脂杀虫剂
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,2-Dimethyl-3-(2-methyl-propenyl)-cyclopropanecarboxylic acid 2-methyl-4-oxo-3-((E)-penta-2,4-dienyl)-cyclopent-2-enyl ester
• 英文别名: [2-methyl-4-oxo-3-[(2E)-penta-2,4-dienyl]cyclopent-2-en-1-yl] 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate
• CAS: 56586-14-2；121-21-1
• 化学式: C₂₁H₂₈O₃
• 分子量: 328.452
• InChiKey: ROVGZAWFACYCSP-CMDGGOBGSA-N

物化性质

• 比旋光度：
  D20 -14° (isooctane)
• 沸点：
  bp0.0005 146-150°
• 密度：
  1.5192
• 溶解度：
  氯仿（微溶）、乙酸乙酯（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险等级：
  6.1(b)

制备方法与用途

除虫菊素

除虫菊素是天然除虫菊提取物，具备杀虫药用价值。其内含多种成分，包括除虫菊酯Ⅰ、除虫菊酯Ⅱ、瓜菊酯和茉莉菊酯。

除虫菊素具有广谱杀虫作用，主要通过胃毒作用有效防治咀嚼式口器害虫；同时，还具备强烈的触杀作用，主要用于防控刺吸式口器害虫。它击倒速度快，对哺乳动物安全，易降解且不污染环境。

在20世纪40年代中期之前，化学合成农药如有机氯、有机磷和氨基酸甲酯类杀虫剂尚未问世时，除虫菊制剂就已广泛应用于农业害虫防治，并取得了显著效果。从1947年起，人工首次成功合成了拟除虫菊酯，目前已有人工合成的拟除虫菊酯类化合物包括：烯丙菊酯（1947年）、胺菊酯（1963年）、苄呋菊酯（1965年）、苯醚菊酯（1968年）、苄氯菊酯（1972年）、氯氰菊酯（1973年）和溴氰菊酯（1973年），以及非三碳环的杀灭菊酯等。这些合成物不仅药效、光稳定性超过天然除虫菊酯及有机磷、有机氯、氨基甲酸酯类常用合成杀虫剂，还逐步替代了天然物在室内和农业害虫防治中的应用。

图1展示了除虫菊素主要成分除虫菊酯Ⅰ和除虫菊酯Ⅱ的化学结构式。以上信息由Chemicalbook的晓楠编辑整理。

文献信息

• Compounds That Act To Modulate Insect Growth And Methods And Systems For Identifying Such Compounds
  申请人：Henrich Vincent C.

  公开号：US20110207707A1

  公开（公告）日：2011-08-25

  Disclosed are methods and systems for screening for compounds that act to modulate insect growth. Bioassays including cell culture and/or transgenic insects engineered with various components of the ecdysoid receptor (EcR) and/or the farsenoid-X receptor (RXR) systems to identify compounds that act as insecticides and/or hormone receptor activators are described. Also described are compounds, and compositions, identified as being putative insecticides based upon their ability to activate EcR and/or FXR mediated transcription.

  本发明涉及筛选调节昆虫生长的化合物的方法和系统。本发明描述了生物测定方法，包括细胞培养和/或转基因昆虫，这些昆虫经过工程设计，具有各种成分的ecdysoid受体（EcR）和/或farsenoid-X受体（RXR）系统，以识别作为杀虫剂和/或激素受体激活剂的化合物。本发明还描述了通过其激活EcR和/或FXR介导的转录而被认为是杀虫剂的化合物和组合物。
• COMPOSITIONS AND METHODS FOR TREATING SURFACES INFECTED WITH ECTOPARASITIC INSECTS AND/OR PREVENTING RE-INFESTATION BY THE SAME
  申请人：——

  公开号：US20020009476A1

  公开（公告）日：2002-01-24

  Compositions and methods are disclosed for treating a hair-bearing surface of a warm-blooded animal, including humans, dogs and cats infested with an ectoparasitic insect, such as lice and/or fleas. Compositions and methods are also disclosed for preventing the infestation or re-infestation of an ectoparasitic insect, such as lice and/or fleas on a hair-bearing surface of a warm-blooded animal, including humans, dogs and cats. The compositions include either a water-soluble polyalkylene glycol or a water-soluble polyalkylene oxide mixed with a polymer or copolymer comprising polyalkylene oxide having carboxylic acid-containing residues. Methods of the invention include topical application to a hair-bearing surface of an effective amount of a composition of this invention, and maintaining the same on the surface for a sufficient period of time to treat the surface. Further optional steps include washing or rinsing the composition from the surface, as well as combing the hair associated with the treated surface.

  本发明公开了用于治疗温血动物（包括人、狗和猫）受体外寄生昆虫（如虱子和/或跳蚤）侵扰的毛发表面的组合物和方法。本发明还公开了用于防止体外寄生昆虫（如虱子和/或跳蚤）在温血动物（包括人、狗和猫）的毛发表面寄生或再次寄生的组合物和方法。组合物包括水溶性聚亚烷基二醇或水溶性聚环氧烷与聚合物或共聚物混合，聚合物或共聚物包括具有含羧酸残留物的聚环氧烷。本发明的方法包括在毛发表面局部施用有效量的本发明组合物，并在毛发表面保持足够的时间以处理毛发表面。进一步的可选步骤包括清洗或冲洗表面的组合物，以及梳理与处理过的表面相关的头发。
• COMPOSITIONS AND METHODS FOR DELOUSING
  申请人：——

  公开号：US20020022014A1

  公开（公告）日：2002-02-21

  Compositions and methods are disclosed for delousing warm-blooded animals, in need thereof, including humans. The compositions include either a water-soluble polyalkylene glycol or a water-soluble polyalkylene oxide mixed with a polymer or copolymer comprising polyalkylene oxide having carboxylic acid-containing residues. Methods of the invention include topical application to a hair-bearing surface of an effective amount of a composition of this invention, and maintaining the same on the surface for a sufficient period of time to delouse the surface. Further optional steps include washing or rinsing the composition from the surface, as well as combing the hair associated with the treated surface.

  本发明公开了用于给包括人类在内的需要脱毛的温血动物脱毛的组合物和方法。这些组合物包括水溶性聚亚烷基二醇或水溶性聚环氧烷与含有含羧酸残基的聚环氧烷的聚合物或共聚物混合。本发明的方法包括在毛发表面局部施用有效量的本发明组合物，并在毛发表面保持足够的时间使毛发表面脱毛。进一步的可选步骤包括清洗或冲洗表面的组合物，以及梳理与处理过的表面相关的头发。
• Methods, compositions, and systems for the identification of species-specific or developmental stage-specific insecticides
  申请人：Henrich C. Vincent

  公开号：US20080020381A1

  公开（公告）日：2008-01-24

  Ecdysteroid action in Drosophila melanogaster and other insects is mediated by the dimerization of two nuclear receptors, the ecdysone receptor (EcR) and Ultraspiracle (USP), which regulate the transcription of target genes. Disclosed are nucleic acid constructs to identify insecticides having the ability to modify insect development and growth in a developmental stage-specific and/or species-specific manner.
• Pyrethrin Based Repellant
  申请人：Palkki Kent M.

  公开号：US20120241532A1

  公开（公告）日：2012-09-27

  Disclosed herein are insect repellant formulations and dispensing systems which avoid the need for synergists while still using highly effective pyrethrin repellant compounds. The formulations preferably are presented in aerosol form.