H-Aib-D-Ser(Bzl)-D-Trp(Ψ)-Pim | 661472-80-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Aib-D-Ser(Bzl)-D-Trp(Ψ)-Pim
• 英文别名: 2-amino-N-[(2R)-1-[[(1R)-2-(1H-indol-3-yl)-1-(5-phenyl-1H-imidazol-2-yl)ethyl]amino]-1-oxo-3-phenylmethoxypropan-2-yl]-2-methylpropanamide
• CAS: 661472-80-6
• 化学式: C₃₃H₃₆N₆O₃
• 分子量: 564.687
• InChiKey: MNYNKPPSQJOFJK-XRKRLSELSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  42
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  138
• 氢给体数：
  5
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  9H-fluoren-9-ylmethyl N-[(2R)-1-[[(1R)-2-(1H-indol-3-yl)-1-(5-phenyl-1H-imidazol-2-yl)ethyl]amino]-1-oxo-3-phenylmethoxypropan-2-yl]carbamate 、 N-叔丁氧羰基-2-甲基丙氨酸 在 三(2-氨基乙基)胺 、 1-羟基苯并三唑 、 N,N'-二异丙基碳二亚胺 作用下， 反应 0.5h， 生成 H-Aib-D-Ser(Bzl)-D-Trp(Ψ)-Pim
  参考文献：
  名称：

  [EN] COMPOSITION AND METHODS FOR STIMULATING GASTROINTESTINAL MOTILITY
  [FR] COMPOSITION ET PROCEDES DE STIMULATION DE LA MOTILITE GASTROINTESTINALE

  摘要：

  公开号：

  WO2007041278A3

文献信息

• METHOD FOR INHIBITING INFLAMMATION and PRO-INFLAMMATORY CYTOKINE/CHEMOKINE EXPRESSION USING A GHRELIN ANALOGUE
  申请人：Ipsen Pharma S.A.S.

  公开号：US20160206700A1

  公开（公告）日：2016-07-21

  The present invention provides a method of ameliorating inflammation, inhibiting proinflammatory cytokine and/or chemokine expression and treating various diseases and/or conditions incidental to the onset of inflammation, in a subject in need of treatment for such conditions, by administering select analogues of native hGhrelin.

  本发明提供了一种改善炎症、抑制促炎细胞因子和/或趋化因子表达以及治疗与炎症发作相关的各种疾病和/或病况的方法，通过给予选择性的天然hGhrelin类似物来治疗需要治疗此类病况的受试者。
• Compositions and Methods for Stimulating Gastrointestinal Motility
  申请人：Datta Rakesh

  公开号：US20090304724A1

  公开（公告）日：2009-12-10

  The present invention relates to a method of treating a transient impairment of the motility of the gastrointestinal system resulting from postoperative ileus in a patient wherein said method includes the step of administering a therapeutically effective amount of a peptidyl analog of ghrelin to said patient.

  本发明涉及一种治疗患者术后肠梗阻所导致的胃肠系统运动暂时障碍的方法，其中该方法包括向患者给予治疗有效量的ghrelin的肽类类似物。
• COMPOSITIONS AND METHODS FOR STIMULATING GASTROINTESTINAL MOTILITY
  申请人：Datta Rakesh

  公开号：US20110166069A1

  公开（公告）日：2011-07-07

  The present invention relates to a method of treating a transient impairment of the motility of the gastrointestinal system resulting from postoperative ileus in a patient wherein said method includes the step of administering a therapeutically effective amount of a peptidyl analog of ghrelin to said patient.

  本发明涉及一种治疗因术后肠梗阻引起的胃肠系统运动暂时受损的方法，其中该方法包括给该患者注射治疗有效量的胃泌素类似物。
• Composition and Methods for Stimulating Gastrointestinal Motility
  申请人：IPSEN PHARMA S.A.S.

  公开号：US20150218245A1

  公开（公告）日：2015-08-06

  The present invention relates to a method of treating a transient impairment of the motility of the gastrointestinal system resulting from postoperative ileus in a patient wherein said method includes the step of administering a therapeutically effective amount of a peptidyl analog of ghrelin to said patient.

  本发明涉及一种治疗由术后肠梗阻引起的胃肠系统运动暂时受损的方法，其中该方法包括向患者施用治疗有效量的ghrelin的肽类类似物。
• Growth hormone releasing peptides
  申请人：Dong Zheng Xin

  公开号：US20080242619A1

  公开（公告）日：2008-10-02

  Disclosed are peptide and peptidomimetic compounds generally according to formula (I), and pharmaceutically acceptable salts thereof, that are useful as GHRP analogs: R 1 -A 1 -A 2 -A 3 -A 4 -A 5 -R 2 (I) or a pharmaceutically acceptable salt thereof, wherein: A 1 is Aib, Apc or Inp; A 2 is D-Bal, D-Bip, D-Bpa, D-Dip, D-1Nal, D-2Nal, D-Ser(Bzl), or D-Trp; A 3 is D-Bal, D-Bip, D-Bpa, D-Dip, D-1Nal, D-2Nal, D-Ser(Bzl), or D-Trp; A 4 is 2Fua, Orn, 2Pal, 3Pal, 4Pal, Pff, Phe, Pim, Taz, 2Thi, 3Thi, Thr(Bzl); A 5 is Apc, Dab, Dap, Lys, Orn, or deleted; R 1 is hydrogen, (C 1-6 )alkyl, (C 5-14 )aryl, (C 1-6 )alkyl(C 5-14 )aryl, (C 3-8 )cycloakyl, or (C 2-10 )acyl; and R 2 is OH or NH 2 ; and pharmaceutical compositions and methods of use thereof.