3-(2-bromopropanamido)-4-methoxy-N-(3,4,5-trimethoxyphenyl)benzamide | 1001426-49-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(2-bromopropanamido)-4-methoxy-N-(3,4,5-trimethoxyphenyl)benzamide
• 英文别名: 3-(2-bromopropanoylamino)-4-methoxy-N-(3,4,5-trimethoxyphenyl)benzamide
• CAS: 1001426-49-8
• 化学式: C₂₀H₂₃BrN₂O₆
• 分子量: 467.316
• InChiKey: FMSAPLQSZMFMOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  95.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-amino-4-methoxy-N-(3,4,5-trimethoxyphenyl)benzamide 、 2-溴丙酰溴 以 N,N-二甲基甲酰胺 为溶剂， 生成 3-(2-bromopropanamido)-4-methoxy-N-(3,4,5-trimethoxyphenyl)benzamide
  参考文献：
  名称：

  3-(2′-Bromopropionylamino)-benzamides as novel S-phase arrest agents

  摘要：

  We report the synthesis, anti proliferative activity, and SAR of novel 3-(2'-bromopropionylamino)-benzamides. Many of the benzamide compounds showed potent cytotoxicities against Molt-3 leukemia cells. Several compounds exihibited cytotoxicities (under 6.5 mu M) against five solid tumor cell lines. The mechanism of action of the most potent benzamide 101 does not involve targeting on tubulin but it causes cell cycle S-phase arrest. This active S-phase arrest agent merits further investigation. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.10.016

文献信息

• 3-AMIDOBENZAMIDES AND USES THEREOF FOR INCREASING CELLULAR LEVELS OF A3G AND OTHER A3 FAMILY MEMBERS
  申请人：Northwestern University

  公开号：US20160052870A1

  公开（公告）日：2016-02-25

  Disclosed are novel benzamide compounds and the uses thereof for treating diseases and disorders in a patient in need thereof by increasing cellular levels of A3G and/or other members of the A3 family of proteins in the patient. The disclosed compounds include 3 -benzamide compounds that may be administered to treat an HIV-1 infection or cancer in a patient.

  本发明涉及一种新型苯甲酰胺化合物及其用途，通过增加患者体内A3G和/或A3家族蛋白的细胞水平来治疗患者需要的疾病和障碍。所披露的化合物包括3-苯甲酰胺化合物，可用于治疗患者的HIV-1感染或癌症。
• US9688637B2
  申请人：——

  公开号：US9688637B2

  公开（公告）日：2017-06-27
• [EN] 3-AMIDOBENZAMIDES AND USES THEREOF FOR INCREASING CELLULAR LEVELS OF A3G<br/>[FR] 3-AMIDOBENZAMIDES ET LEURS UTILISATIONS POUR AUGMENTER LES TAUX CELLULAIRES D'A3G
  申请人：UNIV NORTHWESTERN

  公开号：WO2016029136A1

  公开（公告）日：2016-02-25

  Disclosed are novel benzamide compounds and the uses thereof for treating diseases and disorders in a patient in need thereof by increasing cellular levels of A3G and/or other members of the A3 family of proteins in the patient. The disclosed compounds include 3-benzamide compounds that may be administered to treat an HIV- 1 infection or cancer in a patient.
• 3-(2′-Bromopropionylamino)-benzamides as novel S-phase arrest agents
  作者：Laixing Hu、Zhuo-rong Li、Jian-Nong Li、Jinrong Qu、Jian-Dong Jiang、David W. Boykin

  DOI：10.1016/j.bmcl.2007.10.016

  日期：2007.12

  We report the synthesis, anti proliferative activity, and SAR of novel 3-(2'-bromopropionylamino)-benzamides. Many of the benzamide compounds showed potent cytotoxicities against Molt-3 leukemia cells. Several compounds exihibited cytotoxicities (under 6.5 mu M) against five solid tumor cell lines. The mechanism of action of the most potent benzamide 101 does not involve targeting on tubulin but it causes cell cycle S-phase arrest. This active S-phase arrest agent merits further investigation. (c) 2007 Elsevier Ltd. All rights reserved.