3-[4-(2-bromo-ethoxy)-phenyl]-propionic acid | 100126-01-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 3-[4-(2-bromo-ethoxy)-phenyl]-propionic acid
• 英文别名: 3-[4-(2-Brom-aethoxy)-phenyl]-propionsaeure；3-[4-(2-Bromoethoxy)phenyl]propanoic acid
• CAS: 100126-01-0
• 化学式: C₁₁H₁₃BrO₃
• 分子量: 273.126
• InChiKey: PSLYKOLURGNFLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-[4-(2-bromo-ethoxy)-phenyl]-propionic acid 生成 3-[4-(2-dimethylamino-ethoxy)-phenyl]-propionic acid
  参考文献：
  名称：

  The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families

  摘要：

  We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes.

  DOI：

  10.1007/bf02886269
• 作为产物：
  描述：

  对羟基苯丙酸 、 1,2-二溴乙烷 在 sodium hydroxide 作用下， 生成 3-[4-(2-bromo-ethoxy)-phenyl]-propionic acid
  参考文献：
  名称：

  The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families

  摘要：

  We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes.

  DOI：

  10.1007/bf02886269

文献信息

• US4461905A
  申请人：——

  公开号：US4461905A

  公开（公告）日：1984-07-24
• [EN] 3-ARYL-ALPHA-AMINO PROPANOIC ACID DERIVATIVES AND A PROCESS FOR THEIR PREPARATION<br/>[FR] DERIVES D'ACIDE 3-ARYL-ALPHA-AMINO PROPANOIQUE ET PROCEDE DE PREPARATION
  申请人：REDDY RESEARCH FOUNDATION

  公开号：WO2003002514A1

  公开（公告）日：2003-01-09

  The present invention relates to novel antidiabetic compounds, their derivatives, their analogs and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel 3-aryl propanoic acid of the general formula (I), their derivatives, their analogs and pharmaceutically acceptable compositions containing them wherein R represents hydroxy or a protecting group such as (C1-C8)alkoxy-CH2-O-, mesylate, tosylate, triflate or halogen atom such as fluorine, chlorine, bromine or iodine.
• The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families
  作者：Jinying Zhao、Heng Wang、Momiao Xiong、Wei Huang、Jin Zuo、Zhu Chen、Boqin Qiang、Qi Sun、Yuxiu Li、Qiuying Liu、Weinan Du、Jialun Chen、Wei Ding、Wentao Yuan、Yang Zhao、Hongyan Xu、Li Jin、Fude Fang

  DOI：10.1007/bf02886269

  日期：2000.10

  We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes.