(5Z)-2-(4-hydroxyanilino)-5-(1H-indol-3-ylmethylidene)-1,3-thiazol-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (5Z)-2-(4-hydroxyanilino)-5-(1H-indol-3-ylmethylidene)-1,3-thiazol-4-one
• 化学式: C₁₈H₁₃N₃O₂S
• 分子量: 335.4
• InChiKey: FDROHGNBKPFIAH-SXGWCWSVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  103
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• PHARMACEUTICAL COMPOSITION FOR STROKE TREATMENT BASED ON AMPK INHIBITION
  申请人：INDUSTRY ACADEMY COOPERATION FOUNDATION OF SEJONG UNIVERSITY

  公开号：US20190167647A1

  公开（公告）日：2019-06-06

  A method for treating stroke in a subject includes administering to the subject a composition that includes a compound having a structure represented by Formula 1 as an active ingredient. The composition may treat a stroke by inhibiting 5′ adenosine monophosphate-activated protein kinase (AMPK) activity of zinc neurotoxicity which is a main cause of strokes. The stroke may include hemorrhagic stroke, ischemic stroke or metal toxicity stroke.