(E)-1-(1-(1H-imidazol-1-yl)-2-(4-methoxyphenyl)vinyl)-1H-pyrazole | 1589050-81-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (E)-1-(1-(1H-imidazol-1-yl)-2-(4-methoxyphenyl)vinyl)-1H-pyrazole
• 英文别名: 1-[(E)-1-imidazol-1-yl-2-(4-methoxyphenyl)ethenyl]pyrazole
• CAS: 1589050-81-6
• 化学式: C₁₅H₁₄N₄O
• 分子量: 266.302
• InChiKey: KFVYJCKAYIVZMH-RVDMUPIBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  44.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(2,2-二氟乙烯基)-4-甲氧基苯 在 potassium phosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 生成 (E)-1-(1-(1H-imidazol-1-yl)-2-(4-methoxyphenyl)vinyl)-1H-pyrazole
  参考文献：
  名称：

  Synthesis of N-(α-Fluorovinyl)azoles by the Reaction of Difluoroalkenes with Azoles

  摘要：

  A mild and versatile method for the construction of C-N bonds by the reaction of (2,2-difluorovinyl)arenes with various N-H-containing heterocycles in the presence of K3PO4 has been developed. The reaction proceeded efficiently at room temperature (25 degrees C) affording the (E)-N-alpha-fluorovinyl derivatives of azoles 3 in good to excellent yields with relatively high stereoselectivity.

  DOI：

  10.1021/jo5005845

文献信息

• Synthesis of <i>N</i>-(α-Fluorovinyl)azoles by the Reaction of Difluoroalkenes with Azoles
  作者：Yang Xiong、Xuxue Zhang、Tao Huang、Song Cao

  DOI：10.1021/jo5005845

  日期：2014.7.18

  A mild and versatile method for the construction of C-N bonds by the reaction of (2,2-difluorovinyl)arenes with various N-H-containing heterocycles in the presence of K3PO4 has been developed. The reaction proceeded efficiently at room temperature (25 degrees C) affording the (E)-N-alpha-fluorovinyl derivatives of azoles 3 in good to excellent yields with relatively high stereoselectivity.