4-(3-Diaethylamino-propylamino)-biphenyl | 14275-72-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(3-Diaethylamino-propylamino)-biphenyl
• 英文别名: N',N'-diethyl-N-(4-phenylphenyl)propane-1,3-diamine
• CAS: 14275-72-0
• 化学式: C₁₉H₂₆N₂
• 分子量: 282.429
• InChiKey: UICCVLWRLNYCPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,4-二溴苯 在 palladium diacetate 、 tris(dibenzylideneacetone)dipalladium (0) 、 sodium carbonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 、 三苯基膦 、 sodium t-butanolate 作用下， 以 1,4-二氧六环 为溶剂， 反应 18.0h， 生成 4-(3-Diaethylamino-propylamino)-biphenyl
  参考文献：
  名称：

  Exploiting a basic chemosensitizing pharmacophore hypothesis. Part 1: Synthesis and biological evaluation of novel arylbromide and bicyclic chemosensitizers against drug-resistant malaria parasites

  摘要：

  An exploratory series of novel arylbromide and bicyclic chemosensitizers (modulators) against chloroquine-resistant Plasinodium falciparum were designed and synthesized on the basis of a basic chemosensitizing pharmacophore hypothesis in malaria. ortho-Substituted bromo and biphenyl ether compounds displayed the best activity from the series. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.04.033

文献信息

• Exploiting a basic chemosensitizing pharmacophore hypothesis. Part 1: Synthesis and biological evaluation of novel arylbromide and bicyclic chemosensitizers against drug-resistant malaria parasites
  作者：Franck Chouteau、David Ramanitrahasimbola、Philippe Rasoanaivo、Kelly Chibale

  DOI：10.1016/j.bmcl.2005.04.033

  日期：2005.6

  An exploratory series of novel arylbromide and bicyclic chemosensitizers (modulators) against chloroquine-resistant Plasinodium falciparum were designed and synthesized on the basis of a basic chemosensitizing pharmacophore hypothesis in malaria. ortho-Substituted bromo and biphenyl ether compounds displayed the best activity from the series. (c) 2005 Elsevier Ltd. All rights reserved.