cis,cis-2-Chloro-2,4-hexadienedioic acid | 76572-57-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: cis,cis-2-Chloro-2,4-hexadienedioic acid
• 英文别名: 2-Chlormuconsaeure；α-Chlormuconsaeure；2-chloro-hexa-2c,4c-dienedioic acid；2-Chlor-hexa-2c,4c-diendisaeure；2-Chloro-cis,cis-muconic acid；(2E,4Z)-2-chlorohexa-2,4-dienedioic acid
• CAS: 76572-57-1
• 化学式: C₆H₅ClO₄
• 分子量: 176.556
• InChiKey: OZNNVVBQWHRHHH-HSFFGMMNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-氯邻苯二酚 在 poplar callus genetically modified with cbnA gene 作用下， 以 水 为溶剂， 反应 8.0h， 生成 cis,cis-2-Chloro-2,4-hexadienedioic acid
  参考文献：
  名称：

  Stable Expression of the Chlorocatechol Dioxygenase Gene fromRalstonia eutrophaNH9 in Hybrid Poplar Cells

  摘要：

  将土壤细菌 Ralstonia eutropha NH9 中编码儿茶酚二氧酶的 cbnA 基因导入杂交杨树（震颤杨×震颤杨），该基因受改良的花椰菜花叶病毒 35S 启动子控制。通过 PCR 和基因组 Southern 印迹分析确认了 cbnA 基因在转基因杨树中的整合。cbnA 基因的表达通过 Western 印迹分析进行了分析。转基因杨树胼胝体能有效地将 3-氯邻苯二酚转化为 2-氯-顺式、顺式-粘菌酸。

  DOI：

  10.1271/bbb.80848

文献信息

• Synthesis Of Muconic Acids By Peracetic Acid Oxidation Of Catechols
  作者：A. Bruce McKague

  DOI：10.1080/00397919908086126

  日期：1999.5

  Abstract Monomeric and dimeric muconic acids were prepared in 30-83% yield by oxidation of catechols with peracetic acid in acetic acid.

  摘要 通过在乙酸中用过乙酸氧化儿茶酚，制备了单体和二聚体粘康酸，产率 30-83%。
• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。
• Regulatory sequence for plants
  申请人：CERES, INC.

  公开号：US10329575B2

  公开（公告）日：2019-06-25

  The present invention provides DNA molecules as shown in SEQ ID NO:2199 that constitute fragments of the genome of a plant. The DNA molecules are useful for specifying a gene product in cells as regulatory sequences. One of ordinary skill in the art, having this data, can obtain cloned DNA fragments, synthetic DNA fragments or polypeptides constituting desired sequences by recombinant methodology known in the art or described therein.

  本发明提供如 SEQ ID NO:2199 所示的 DNA 分子，它们构成植物基因组的片段。这些 DNA 分子可作为调控序列用于指定细胞中的基因产物。掌握这些数据的本领域普通技术人员可以通过本领域已知的或其中描述的重组方法获得克隆 DNA 片段、合成 DNA 片段或构成所需序列的多肽。
• Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
  申请人：Alexandrov Nickolai

  公开号：US20060048240A1

  公开（公告）日：2006-03-02

  The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an UTR or as a 3′ termination sequence, and are also useful in controlling the behavior of a gene in the chromosome, in controlling the expression of a gene or as tools for genetic mapping, recognizing or isolating identical or related DNA fragments, or identification of a particular individual organism, or for clustering of a group of organisms with a common trait. One of ordinary skill in the art, having this data, can obtain cloned DNA fragments, synthetic DNA fragments or polypeptides constituting desired sequences by recombinant methodology known in the art or described herein.

  本发明提供了构成植物基因组片段的DNA分子及其编码的多肽。这些 DNA 分子可作为启动子或蛋白质编码序列或 UTR 或 3′终止序列，用于指定细胞中的基因产物，也可用于控制染色体中基因的行为，控制基因的表达，或作为基因绘图、识别或分离相同或相关 DNA 片段、或识别特定生物个体或具有共同性状的生物群体的工具。掌握这些数据的本领域普通技术人员可以通过本领域已知的或本文所述的重组方法获得克隆 DNA 片段、合成 DNA 片段或构成所需序列的多肽。
• Synthesis of Bacterial Metabolites from Haloaromatic Degradation. 1. Fe(III)-Catalyzed Peracetic Acid Oxidation of Halocatechols, a Facile Entry to cis,cis-2-Halo-2,4-hexadienedioic Acids and 3-Halo-5-oxo-2(5H)-furanylideneacetic Acids
  作者：Stefan Rudolf Kaschabek、Walter Reineke

  DOI：10.1021/jo00093a036

  日期：1994.7