2-Aminomuconic acid | 4548-99-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Aminomuconic acid
• 英文别名: (2Z,4E)-2-aminohexa-2,4-dienedioic acid
• CAS: 4548-99-6
• 化学式: C₆H₇NO₄
• 分子量: 157.12
• InChiKey: ZRHONLCTYUYMIQ-TZFCGSKZSA-N

物化性质

• 沸点：
  368.4±32.0 °C(Predicted)
• 密度：
  1.461±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2922499990

文献信息

• [EN] NICOTINAMIDE MONONUCLEOTIDE AND NICOTINAMIDE RIBOSIDE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF VIRAL INFECTIONS AND RESPIRATORY COMPLICATIONS, IN PARTICULAR CAUSED BY INFLUENZAVIRUS OR CORONAVIRUS<br/>[FR] DÉRIVÉS DE NICOTINAMIDE MONONUCLÉOTIDE ET DE NICOTINAMIDE RIBOSIDE ET LEUR UTILISATION DANS LE TRAITEMENT D'INFECTIONS VIRALES ET DE COMPLICATIONS RESPIRATOIRES, PROVOQUÉES EN PARTICULIER PAR LE VIRUS DE LA GRIPPE OU LE CORONAVIRUS
  申请人：NUVAMID SA

  公开号：WO2021214299A1

  公开（公告）日：2021-10-28

  The present invention relates to Nicotinamide mononucleotide derivatives of formula (I) or (Ia) for use in the treatment and/or prevention of viral infections, such as respiratory infections. The present invention further relates to pharmaceutical compositions comprising compounds of formula (I) or (Ia) for use in the treatment and/or prevention of viral infections.

  本发明涉及式(I)或(Ia)的烟酰胺单核苷酸衍生物，用于治疗和/或预防病毒感染，如呼吸道感染。本发明还涉及包含式(I)或(Ia)的化合物的制药组合物，用于治疗和/或预防病毒感染。
• Directed evolution of recombinant monooxygenase nucleic acids and related polypeptides and methods of use
  申请人：Wood K. Thomas

  公开号：US20060051782A1

  公开（公告）日：2006-03-09

  The present invention relates to novel monooxygenase nucleic acids and polypeptides created using mutagenesis, DNA shuffling, or both, in a single iteration or multiple iterations, and methods for their creation and use. The monooxygenase enzymes of the present disclosure have particular utility as biocatalysts in industrial chemical redox reactions, such as the oxidation of aromatic hydrocarbons, for example, toluene, benzene, or nitrobenzene, into industrially desirable products. The systems and processes of the present invention are especially useful for the coupled synthesis and recovery of catechols, methylcatechols, resorcinols, methylresorcinols, hydroquinones, methylhydroquinones, hydroxybenzenes, cresols, nitrobenzenes, and nitrohydroxyquinones.

  本发明涉及使用突变、DNA重组或两者结合的方法，在单次迭代或多次迭代中创建的新型单加氧酶核酸和多肽，以及它们的创建和使用方法。本公开的单加氧酶酶在工业化学氧化还原反应中具有特定的生物催化剂实用性，例如将芳香族烃类（例如甲苯、苯或硝基苯）氧化成工业上所需的产品。本发明的系统和过程特别适用于咖啡酚、甲基咖啡酚、间苯二酚、甲基间苯二酚、对苯二酚、甲基对苯二酚、羟基苯、甲酚、硝基苯和硝基羟基苯的耦合合成和回收。
• [EN] NICOTINAMIDE MONONUCLEOTIDE DERIVATIVES AND USE THEREOF FOR THE TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION<br/>[FR] DÉRIVÉS MONONUCLÉOTIDIQUES NICOTINAMIDES ET LEUR UTILISATION POUR LE TRAITEMENT DE L'INSUFFISANCE CARDIAQUE À FRACTION D'ÉJECTION PRÉSERVÉE
  申请人：NUVAMID SA

  公开号：WO2022263625A1

  公开（公告）日：2022-12-22

  The present invention relates to nicotinamide mononucleotide derivatives of Formula (I) or pharmaceutically acceptable salts or solvates thereof, for use in the treatment of heart failure with preserved ejection fraction (HFpEF) in a subject in need thereof.

  本发明涉及公式（I）的烟酰胺单核苷酸衍生物或其药学上可接受的盐或溶剂，用于治疗需要治疗心脏收缩功能保留型心力衰竭（HFpEF）的患者。
• [EN] NICOTINAMIDE MONONUCLEOTIDE DERIVATIVES AND USE THEREOF IN THE STIMULATION OF THE EXPRESSION OF FETAL HEMOGLOBIN<br/>[FR] DÉRIVÉS DE NICOTINAMIDE MONONUCLÉOTIDE ET LEUR UTILISATION DANS LA STIMULATION DE L'EXPRESSION DE L'HÉMOGLOBINE FOETALE
  申请人：NUVAMID SA

  公开号：WO2022129536A1

  公开（公告）日：2022-06-23

  The present invention relates to nicotinamide mononucleotide derivatives of Formula (I) for use in the stimulation of the expression of fetal hemoglobin. The present invention further relates to pharmaceutical compositions comprising compounds of Formula (I) for use in the stimulation of the expression of fetal hemoglobin.

  本发明涉及公式（I）的烟酰胺单核苷酸衍生物，用于刺激胎儿血红蛋白的表达。本发明还涉及含有公式（I）化合物的药物组合物，用于刺激胎儿血红蛋白的表达。
• NICOTINAMIDE MONONUCLEOTIDE AND NICOTINAMIDE RIBOSIDE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF VIRAL INFECTIONS AND RESPIRATORY COMPLICATIONS, IN PARTICULAR CAUSED BY INFLUENZAVIRUS OR CORONAVIRUS
  申请人：Nuvamid SA

  公开号：EP3901160A1

  公开（公告）日：2021-10-27

  The present invention relates to Nicotinamide mononucleotide derivatives of formula (I) for use in the treatment and/or prevention of viral infections, such as respiratory infections The present invention further relates to pharmaceutical compositions comprising compounds of formula (I) for use in the treatment and/or prevention of viral infections.

  本发明涉及式 (I) 的烟酰胺单核苷酸衍生物 本发明还涉及用于治疗和/或预防病毒感染（如呼吸道感染）的包含式（I）化合物的药物组合物。