(1R)-1-benzyl-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: (1R)-1-benzyl-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol
• 化学式: C₁₈H₂₁NO₂
• 分子量: 283.4
• InChiKey: TXBIVOUMLHWHLV-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Compositions and methods for making (R)-Reticuline and precursors thereof
  申请人：Epimeron Inc.

  公开号：US10190141B2

  公开（公告）日：2019-01-29

  Methods that may be used for the manufacture of the chemical compound (R)-Reticuline and synthesis precursors thereof. Compositions useful for the synthesis (R)-Reticuline and synthesis precursors are also provided.

  可用于制造 (R)-Reticuline 化合物及其合成前体的方法。此外，还提供了用于合成 (R)-Reticuline 及其合成前体的组合物。
• Compositions and methods for producing benzylisoquinoline alkaloids
  申请人：California Institute of Technology

  公开号：US10240176B2

  公开（公告）日：2019-03-26

  The present invention relates to host cells that produce compounds that are characterized as benzylisoquinolines, as well as select precursors and intermediates thereof. The host cells comprise one, two or more heterologous coding sequences wherein each of the heterologous coding sequences encodes an enzyme involved in the metabolic pathway of a benzylisoquinoline, or its precursors or intermediates from a starting compound. The invention also relates to methods of producing the benzylisoquinoline, as well as select precursors and intermediates thereof by culturing the host cells under culture conditions that promote expression of the enzymes that produce the benzylisoquinoline or precursors or intermediates thereof.

  本发明涉及可产生苄基异喹啉类化合物及其特定前体和中间体的宿主细胞。宿主细胞包括一个、两个或多个异源编码序列，其中每个异源编码序列编码一种酶，该酶参与从起始化合物到苄基异喹啉或其前体或中间体的代谢途径。本发明还涉及在促进产生苄基异喹啉或其前体或中间体的酶的表达的培养条件下培养宿主细胞，从而生产苄基异喹啉及其精选前体和中间体的方法。
• Engineered benzylisoquinoline alkaloid epimerases and methods of producing benzylisoquinoline alkaloids
  申请人：Antheia, Inc.

  公开号：US11427827B2

  公开（公告）日：2022-08-30

  The present disclosure provides systems and methods for increasing production of an alkaloid product through the epimerization of a (S)-1-benzylisoquinoline alkaloid to a (R)-1-benyzlisoquinoline alkaloid via an engineered epimerase in an engineered host cell. A (S)-1-benzylisoquinoline alkaloid is contacted with said engineered epimerase. Contacting said (S)-1-benzylisoquinoline alkaloid with said engineered epimerase converts said (S)-1-benzylisoquinoline alkaloid to said (R)-1-benzylisoquinoline alkaloid.

  本公开提供了通过工程宿主细胞中的工程表聚酶将(S)-1-苄基异喹啉生物碱表聚为(R)-1-苄基异喹啉生物碱来提高生物碱产品产量的系统和方法。将(S)-1-苄基异喹啉生物碱与所述工程表聚酶接触。将所述(S)-1-苄基异喹啉生物碱与所述工程表聚酶接触，将所述(S)-1-苄基异喹啉生物碱转化为所述(R)-1-苄基异喹啉生物碱。
• Cytochrome P450 reductases from poppy plants
  申请人：Kutchan M. Toni

  公开号：US20060185032A1

  公开（公告）日：2006-08-17

  The present invention relates to production of alkaloids from poppy plants and in particular togenes encoding enzymes in the alkaloid pathway, to proteins encoded by the gens, to plants transformed or transfected with the genes and to methods of altering alkaloid content or blend of poppy plants.

  本发明涉及从罂粟植物中生产生物碱，特别是生物碱途径中编码酶的基因、基因编码的蛋白质、用基因转化或转染的植物以及改变罂粟植物生物碱含量或混合的方法。
• METHODS OF PRODUCING EPIMERASES AND BENZYLISOQUINOLINE ALKALOIDS
  申请人：The Board of Trustees of The Leland Stanford Junior University

  公开号：EP3294865A1

  公开（公告）日：2018-03-21