(4R,4aS,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;hydron;chloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: (4R,4aS,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;hydron;chloride
• 化学式: C18H22ClNO4
• 分子量: 351.8
• InChiKey: MUZQPDBAOYKNLO-CJJIHIERSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.47
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  59
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• METHODS TO TREAT PAIN USING AN ALPHA-2 ADRENERGIC AGONIST AND AN ENDOTHELIN ANTAGONIST
  申请人：Endogenx, Inc.

  公开号：EP2330903A1

  公开（公告）日：2011-06-15
• Methods to Treat Pain Using an Alpha-2 Adrenergic Agonist and an Endothelin Antagonist
  申请人：Gulati Anil

  公开号：US20100022574A1

  公开（公告）日：2010-01-28

  The present invention relates, in general to treatment of pain comprising administering an alpha-2 adrenergic agonist and an endothelin antagonist, wherein administration of the agents acts as an analgesic and ameliorates pain in a subject.
• [EN] METHODS TO TREAT PAIN USING AN ALPHA-2 ADRENERGIC AGONIST AND AN ENDOTHELIN ANTAGONIST<br/>[FR] PROCÉDÉS DE TRAITEMENT DE LA DOULEUR À L'AIDE D'UN AGONISTE ADRÉNERGIQUE ALPHA-2 ET D'UN ANTAGONISTE DE L'ENDOTHÉLINE
  申请人：ENDOGENX INC

  公开号：WO2010014076A1

  公开（公告）日：2010-02-04

  The present invention relates, in general to treatment of pain comprising administering an alpha-2 adrenergic agonist and an endothelin antagonist, wherein administration of the agents acts as an analgesic and ameliorates pain in a subject.