核苷中间体在药物合成中扮演着重要角色,特别是在抗病毒和抗癌药物的开发中。这些化合物通常用于合成最终的活性物质。核苷是一类含糖结构的重要生物分子,在体内参与DNA和RNA的构成与代谢。
核苷中间体是指从基本原料出发,通过一系列化学反应合成得到的、接近或直接作为后续步骤前驱体的化合物。它们在药物研发过程中至关重要,因为这些中间体可以提供更便捷的方法来引入特定官能团或结构片段,从而简化整个合成路线,提高产率并减少副产品的生成。
核苷中间体的合成通常包括以下几个关键步骤:
这些中间体在合成过程中具有高度选择性和反应性,在特定条件下能够精确地进行化学转化。因此,它们对于确保目标产品的高质量生产和高效开发至关重要。此外,不同类型的核苷中间体可以用于制备不同的药物分子,如抗病毒药物(例如阿昔洛韦)、抗癌药物以及其他多种生物活性物质。
中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
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2-氨基-4-羟基吡咯并[2,3-d]嘧啶 | 2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | 7355-55-7 | C6H6N4O |
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2-氨基-4-氯吡咯并[2,3-d]嘧啶 | 4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine | 84955-31-7 | C6H5ClN4 |
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2-氨基-3,5-二氢吡咯并[3,2-D]嘧啶-4-酮 | 9-deazaguanine | 65996-58-9 | C6H6N4O |
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2-氟腺苷 | 2-fluoroadenosine | 146-78-1 | C10H12FN5O4 |
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2-C-甲基鸟苷 | 2'-C-methylguanosine | 374750-30-8 | C11H15N5O5 |
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2,6-二氯嘌呤核苷 | 2,6-dichloropurine riboside | 13276-52-3 | C10H10Cl2N4O4 |
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2,6-二巯基嘌呤 | 2,6-Dimercapto-purin | 5437-25-2 | C5H4N4S2 |
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2,2'-脱水尿苷 | 2,2'-Anhydrouridine | 3736-77-4 | C9H10N2O5 |
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2'-甲氧基鸟苷 | 2'-O-methylguanosine | 2140-71-8 | C11H15N5O5 |
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2'-甲氧基胞苷 | 2'-O-methylcytidine | 2140-72-9 | C10H15N3O5 |
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2'-甲氧基尿苷 | 2'-O-methyluridine | 2140-76-3 | C10H14N2O6 |
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2'-氨基-2'-脱氧胞苷 | 2'-amino-2'-deoxycytidine | 26889-42-9 | C9H14N4O4 |
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2'-O-甲基腺苷 | 2'-O-methyl adenosine | 2140-79-6 | C11H15N5O4 |
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2'-C-甲基胞嘧啶核苷 | 2'-C-methylcytidine | 20724-73-6 | C10H15N3O5 |
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2',3'-异丙叉腺苷 | 2',3'-isopropylidene adenosine | 362-75-4 | C13H17N5O4 |
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2',3'-O-异丙叉肌苷 | 2',3'-O-isopropylideneinosine | 2140-11-6 | C13H16N4O5 |
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2',3'-O-异丙亚基鸟苷 | 2',3'-isopropylideneguanosine | 362-76-5 | C13H17N5O5 |
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2',3',5'-三乙酰鸟苷 | 2',3',5'-tri-O-acetyl-guanosine | 6979-94-8 | C16H19N5O8 |
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2',3',5'-三乙酰腺苷 | triacetyladenosine | 7387-57-7 | C16H19N5O7 |
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2',3',5'-三乙酰肌苷 | N-benzyloxycarbonylglycylhistidine | 38972-84-8 | C16H18N4O5 |
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2',3',5'-三乙酰尿苷 | Tri-O-acetyluridine | 4105-38-8 | C15H18N2O9 |
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2',3',5'-三-O-乙酰-2-氨基-6-氯嘌呤核苷 | [3,4-Diacetyloxy-5-(2-amino-6-chloropurin-9-yl)oxolan-2-yl]methyl acetate | 16321-99-6 | C16H18ClN5O7 |
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1-氰基-2,3,5-三苯甲酰氧基-beta-D-呋喃核糖 | (3,4-Dibenzoyloxy-5-cyanooxolan-2-yl)methyl benzoate | 23316-67-8 | C27H21NO7 |
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1-叠氮基-2,3,5-三苯甲酰氧基-beta-D-呋喃核糖 | 2,3,5-tri-O-benzoyl-β-D-ribofuranosyl azide | 7408-41-5 | C26H21N3O7 |
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1-beta-D-阿拉伯呋喃糖基-5-溴尿嘧啶 | bromouridine | 957-75-5 | C9H11BrN2O6 |
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1-((2R,3r,4r,5r)-5-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-4-羟基-3-甲氧基四氢呋喃-2-基)嘧啶-2,4(1h,3h)-二酮 | 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine | 103285-22-9 | C31H32N2O8 |
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1,2-二脱氧-D-核糖 | (2R,3S)-2-(hydroxymethyl)tetrahydrofuran-3-ol | 91547-59-0 | C5H10O3 |
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—— | D-Arabinosyl-5-fluorcytosin | 2341-22-2 | C9H12FN3O5 |
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—— | Sodium N-(9-{6-[(butanoyloxy)methyl]-2-hydroxy-2-oxotetrahydro-2H-2lambda~5~-furo[3,4-d][1,3,2]dioxaphosphol-4-yl}-9H-purin-6-yl)butanimidate | 16980-89-5 | C18H23N5NaO8P |
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—— | 2-amino-9-(<i>O</i><sup>2</sup>,<i>O</i><sup>3</sup>,<i>O</i><sup>5</sup>-triacetyl-ξ-<i>D</i>-xylofuranosyl)-1,9-dihydro-purin-6-one | 6979-94-8 | C16H19N5O8 |
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—— | 7-methyl-guanosinium | 22164-16-5 | C11H17N5O5 |
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—— | Adenosine 5'-triphosphate disodium salt hydrate from microbial source, min. 99% (HPLC) | 34369-07-8 | C10H14N5Na2O14P3-2 |
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—— | disodium;[(1R,2R,3S,4R)-2,3-dihydroxy-4-(6-oxo-1H-purin-9-yl)cyclopentyl]methyl phosphate;hydrate | 352195-40-5 | C11H15N4Na2O8P |
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—— | <i>O</i><sup>2'</sup>,<i>O</i><sup>3'</sup>,<i>O</i><sup>5"</sup>-triacetyl-uridine | 4105-38-8 | C15H18N2O9 |
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—— | 2-(6-Amino-2-chloro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol hydrate | 81012-94-4 | C10H14ClN5O5 |
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—— | sodium 6-(6-amino-8-bromo-purin-9-yl)-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol | 76939-46-3 | C10H10BrN5NaO6P |
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—— | (3xi)-5'-o-[(4-Methylphenyl)sulfonyl]adenosine | 5135-30-8 | C17H19N5O6S |
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—— | 2',3'-O-(1-Methylethylidene)adenosine | 362-75-4 | C13H17N5O4 |
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—— | 2-(4-Amino-5-iodo-7-pyrrolo[2,3-d]pyrimidinyl)-5-(hydroxymethyl)oxolane-3,4-diol | 24386-93-4 | C11H13IN4O4 |
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—— | Adenosine, 3-deaza- | 6736-58-9 | C11H14N4O4 |
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—— | 2'-O-Methylguanosin | 2140-71-8 | C11H15N5O5 |
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—— | 9-{5-o-[(4-Methylphenyl)sulfonyl]pentofuranosyl}-9h-purin-6-amine | 55197-13-2 | C17H19N5O6S |
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—— | 1-[3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-iodo-pyrimidine-2,4-dione | 1024-99-3 | C9H11IN2O6 |
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—— | 9H-Purine,8-diamino-9-beta-D-ribofuranosyl- | 3868-33-5 | C10H14N6O4 |
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—— | 5-Chloro-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione | 2880-89-9 | C9H11ClN2O6 |
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—— | N4-Benzoyl-2-O-methylcytidine | 52571-45-6 | C17H19N3O6 |
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—— | Β-D-Ribofuranosyl)-9-benzylamino-6-purin | 4294-16-0 | C17H19N5O4 |
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—— | N-[9-[5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]purin-6-yl]benzamide | 81246-82-4 | C38H35N5O7 |
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—— | 2’-C-methyladenosine | 15397-12-3 | C11H15N5O4 |
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—— | Adenosine sodio-2',3'-phosphate hydrate | 37063-35-7 | C10H13N5NaO6P |
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