N-benzylnorcodeine methanesulfonate | 130727-25-2

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: N-benzylnorcodeine methanesulfonate
• CAS: 130727-25-2
• 化学式: CH₄O₃S*C₂₄H₂₅NO₃
• 分子量: 471.574
• InChiKey: GRSGJQWTAPYVMC-ZKGMEJJTSA-N

反应信息

• 作为反应物：
  描述：

  N-benzylnorcodeine methanesulfonate 在 甲烷磺酸 作用下， 反应 1.0h， 生成 (R)-N-benzylnorapocodeine
  参考文献：
  名称：

  (R)- and (S)-enantiomers of 11-hydroxy- and 10,11-dihydroxy-N-allylnoraporphine: synthesis and affinity for dopamine receptors in rat brain tissue

  摘要：

  The R-(-)- and S-(+)-enantiomers of 11-hydroxy-N-allyl (4), and 10,11-dihydroxy-N-allyl (3) congeners of 11-hydroxy-N-n-propylnoraporphine (11-OH-NPa, 2) or N-n-propylnorapomorphine (NPA, 1) were synthesized. Binding affinity of these compounds at dopamine (DA) receptor sites was evaluated with a membrane preparation of corpus striatum from rat brain. The R/S enantiomeric receptor affinity ratio was enhanced by allylic substitution of 3 and 4 and their R isomers had high DA receptor affinity similar to that of the N-n-propyl congeners. These N-allylaporphines are proposed as useful precursors to the preparation of their tritiated N-n-propyl enantiomers.

  DOI：

  10.1021/jm00105a005