3-Benzyloxymethyl-1-[(2R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-(2-hydroxy-ethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione | 188198-23-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 3-Benzyloxymethyl-1-[(2R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-(2-hydroxy-ethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
• CAS: 188198-23-4
• 化学式: C₃₅H₄₂N₂O₆Si
• 分子量: 614.814
• InChiKey: ROCJMCCFNXQDEM-YKILCQELSA-N

反应信息

• 作为反应物：
  描述：

  3-Benzyloxymethyl-1-[(2R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-(2-hydroxy-ethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 在 palladium on activated charcoal 吡啶 、 盐酸 、 4-二甲氨基吡啶 、 二异丙基铵盐四氮唑 、 氢气 、 sodium hydride 作用下， 以 二氯甲烷 、 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 88.0h， 生成
  参考文献：
  名称：

  Replacement of the phosphodiester linkage in oligonucleotides by heterocycles: the effect of triazole- and imidazole-modified backbones on DNA/RNA duplex stability

  摘要：

  Thymidine dinucleotide analogs with imidazole-derived backbones (III and IV) were synthesized. These modified dimeric building blocks were incorporated into oligodeoxyribonucleotides. The hybridization affinity of the modified oligonucleotides for RNA complements was determined and compared to the corresponding olefinic modifications I and II. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00270-9
• 作为产物：
  描述：

  3-Benzyloxymethyl-1-[(2R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-vinyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 在 sodium hydroxide 、 9-borabicyclo[3.3.1]nonane dimer 、 双氧水 作用下， 生成 3-Benzyloxymethyl-1-[(2R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-(2-hydroxy-ethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  Replacement of the phosphodiester linkage in oligonucleotides by heterocycles: the effect of triazole- and imidazole-modified backbones on DNA/RNA duplex stability

  摘要：

  Thymidine dinucleotide analogs with imidazole-derived backbones (III and IV) were synthesized. These modified dimeric building blocks were incorporated into oligodeoxyribonucleotides. The hybridization affinity of the modified oligonucleotides for RNA complements was determined and compared to the corresponding olefinic modifications I and II. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00270-9