| 1238848-29-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• CAS: 1238848-29-7
• 化学式: C₂₇H₂₉N₃O₈
• 分子量: 523.543
• InChiKey: QXNIMKYURKMXJS-SODSZRCFSA-N

反应信息

• 作为产物：
  描述：

  在 甲醇 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Click chemistry to probe Hsp90: Synthesis and evaluation of a series of triazole-containing novobiocin analogues

  摘要：

  A series of triazole-containing novobiocin analogues has been designed, synthesized and their inhibitory activity determined. These compounds contain a triazole ring in lieu of the amide moiety present in the natural product. The anti-proliferative effects of these compounds were evaluated against two breast cancer cell lines ( SKBr-3 and MCF-7), and manifested activities similar to their amide-containing counterparts. In addition, Hsp90-dependent client protein degradation was observed via Western blot analyses, supporting a common mode of Hsp90 inhibition for both structural classes. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.140