| 1252592-11-2

• 分子结构分类: 有机化合物
• CAS: 1252592-11-2
• 化学式: C₂₂H₃₇NO₅
• 分子量: 395.539
• InChiKey: IDNQMWGXFAKSSC-COQIJWMOSA-N

反应信息

• 作为产物：
  描述：

  在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 作用下， 以 甲苯 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and evaluation of antimigratory and antiproliferative activities of lipid-linked [13]-macro-dilactones

  摘要：

  The biological activities of a family of novel, lipid-linked 13-membered-ring macro-dilactones are reported. These [13]-macro-dilactones were synthesized by diacylation of functionalized diols, followed by ring-closing metathesis under conditions we had previously reported. Antimigratory, cytostatic and cytotoxic activities of the compounds against cancer cells were evaluated. Compound 13 was the most potent in the series, while compound 10 had the broadest concentration range of subtoxic antiproliferative activity. These compounds share common structural components, namely the [13]-macro-dilactone templated by an octyl alpha-glucoside 4,6-diol. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.07.083